Long-Term Observations of Patients with Acute Retinal Pigment Epitheliitis

Prost, M

doi:10.1159/000310022

Cited by 15 publications

(5 citation statements)

References 3 publications

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“…It is a selflimited disease and usually regresses spontaneously. 4 White dot syndromes should be considered in the differential diagnosis of ARPE, especially multiple evanescent white dot syndromes and acute posterior multifocal placoid pigment epitheliopathy because these tend to have overlapping features. 5 The pathophysiology of ARPE is unknown.…”

Section: Discussionmentioning

confidence: 99%

Multicolor Imaging in a Case of Acute Retinal Pigment Epitheliitis

Roy

Saurabh

Thomas

2021

RETINAL Cases &Amp; Brief Reports

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Purpose: To describe multicolor imaging findings in a case of acute retinal pigment epitheliitis.Setting: Vitreoretinal department of a tertiary care center in Eastern India.Methods: A 28-year-old lady presented with acute vision loss in the right eye since 3 days. Left eye examination was unremarkable. Best-corrected visual acuity in the right eye was 20/40. Anterior segment examination revealed clear lens with no evidence of inflammation. There were no vitreous cells. Fundus examination of the right eye revealed a round orange lesion surrounded by a hypopigmented halo in the fovea with multiple tiny hypopigmented lesions temporal to the fovea. Fundus autofluorescence imaging of the right eye showed hyperautofluorescent lesions temporal to the fovea corresponding to the hypopigmented lesions seen temporal to the fovea. Spectral domain optical coherence tomography of the right eye revealed subfoveal hyperreflective lesion in the outer retina with disruption of the ellipsoid zone and interdigitation zone with a linear extension upward. Multicolor composite image of the right eye revealed the foveal lesion as circular red patch with an inferior orange extension. The infrared reflectance image revealed hyperreflective area corresponding to the foveal lesion. The blue and green reflectance images were unremarkable. The patient reported an upper respiratory tract infection 7 days before the visual loss. A diagnosis of acute retinal pigment epitheliitis was made based on history, clinical and imaging findings.Conclusion: This is the first description of multicolor imaging signature of acute retinal pigment epitheliitis lesion in published literature. It seems to be a promising noninvasive imaging modality with a potential to replace color fundus photography.

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Section: Discussionmentioning

confidence: 99%

Multicolor Imaging in a Case of Acute Retinal Pigment Epitheliitis

Roy

Saurabh

Thomas

2021

RETINAL Cases &Amp; Brief Reports

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“…Bilateral presentation is relatively rare but has been previously described by several authors. 1,[8][9][10] The images reported herein suggest that the disease involves the full thickness of the fovea. Because the images are consistent in both eyes and because "backscatter" occurs into deeper tissues, the findings are unlikely to represent artifact.…”

Section: Discussionmentioning

confidence: 99%

Spectral-Domain Optical Coherence Tomography Findings in Acute Retinal Pigment Epitheliitis

Hall

Ahmad

Schachat

2012

RETINAL Cases &Amp; Brief Reports

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“…2 The disease equally affects males and females, can be either unilateral or bilateral, and usually resolves spontaneously without treatment within a few months. 3,4 Fundus examination shows delicate darkish macular spots surrounded by a lighter halo-like zone. The acute occurrence of the infection and its self-limiting course has suggested that a viral infection could be the origin of the disease.…”

Section: Introductionmentioning

confidence: 99%

A case of acute retinal pigment epithelitis: spectral domain optical coherence tomography time course and physiopathologic hypothesis

Puche

Offret²,

Bernard³

2010

OPTH

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Purpose:To report the time course of retinal morphologic changes in a patient with acute retinal pigment epithelitis (ARPE) using spectral domain optical coherence tomography (SD-OCT). Methods: A 30-year old man was referred for blurred vision of his right eye after five days that appeared suddenly 15 days after recovery from a flu-like syndrome. SD-OCT was performed immediately, followed by fluorescein and infracyanine angiography at eight days and then at three weeks. Results: At presentation, a bubble of sub-macular deposit was observed on the right macula with central golden micronodules in a honeycomb pattern. SD-OCT showed an "anterior dislocation" of all the retinal layers up to the inner/outer segment (IS/OS) line and irregular deposits at the OS level together with thickening of the retinal pigment epithelial (RPE) layer. As visual acuity increased, eight days later, the OCT showed reduction of the sub-retinal deposits and an abnormal hyperflectivity of the sub-retinal and RPE layers was observed. The patient showed a positive serology for picornavirus. Discussion: The acute SD-OCT sections of this patient with ARPE were compared with histological sections of a 35 day old Royal College of Surgeons rat. Similar findings could be observed, with preservation of the IS/OS line and accumulation of debris at the OS level, suggesting that ARPE symptoms could result from a transient phagocytic dysfunction of the RPE at the fovea, inducing reversible accumulation of undigested OS. Picornaviruses comprising enterovirus and coxsachievirus described as being associated with acute chorioretinitis. In this case, it was responsible for ARPE. Conclusion: We hypothesize that ARPE syndrome results from a transient dysfunction of RPE, which can occur as a post viral reaction.

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Long-Term Observations of Patients with Acute Retinal Pigment Epitheliitis

Cited by 15 publications

References 3 publications

Multicolor Imaging in a Case of Acute Retinal Pigment Epitheliitis

Multicolor Imaging in a Case of Acute Retinal Pigment Epitheliitis

Spectral-Domain Optical Coherence Tomography Findings in Acute Retinal Pigment Epitheliitis

A case of acute retinal pigment epithelitis: spectral domain optical coherence tomography time course and physiopathologic hypothesis

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