Spectral-Domain Optical Coherence Tomography Findings in Acute Retinal Pigment Epitheliitis

Hall, Edward F.; Ahmad, Baseer; Schachat, Andrew P.

doi:10.1097/icb.0b013e3182378bd7

Cited by 10 publications

(6 citation statements)

References 9 publications

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“…Optical coherence tomography (OCT) shows two main groups of reported findings. [2][3][4][5][6] In a more modest form of involvement, there is loss of visibility or blurring of the interdigitation and ellipsoid zones because of a poorly defined haze extending up from the level of the RPE toward the external limiting membrane. In the second group, there are one or more plumes of hyperreflectivity extending from the level of the ellipsoid zone through the outer nuclear layer and the Henle's layer of the fovea.…”

mentioning

confidence: 99%

Acute Fovealitis

Ledesma-Gil

Spaide

2020

RETINAL Cases &Amp; Brief Reports

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confidence: 99%

Acute Fovealitis

Ledesma-Gil

Spaide

2020

RETINAL Cases &Amp; Brief Reports

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“…[3][4][5][6][7][8] In the acute phase, UAIM and ARPE can be differentiated on OCT: UAIM shows swelling of the outer retina with presence of hyperreflective exudation and neurosensory retinal detachment, 9 whereas ARPE shows a dome-shaped hyper-reflective lesion at the photoreceptor outer segment layer, 3 which occasionally can involve the full thickness of the fovea. 10 All 3 of our cases presented with inactive disease, and because of the eccentric localization in case 1, the RPE hypertrophy in case 3, the lack of any symptoms of visual disturbance at any time, and the size of all three lesions, they are not entirely typical for UAIM, although they could represent atypical UAIM.…”

Section: Discussionmentioning

confidence: 76%

Incidental unilateral idiopathic maculopathy in children

Georgiou

McAnena

Michaelides

et al. 2020

Journal of American Association for Pediatric Ophthalmology and

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To investigate the clinical findings and differential diagnosis of incidental unilateral discoid maculopathy in a case series of children. METHODS The medical records and retinal imaging of children referred to a single center for flat, well circumscribed, hypopigmented discoid macular lesion in the left eye were reviewed retrospectively. RESULTS Three children (age range, 4-11 years; 2 female), with no subjective ophthalmic complaints, were referred for investigation of a flat, well-circumscribed, hypopigmented discoid macular lesion in the left eye. Case 1 had a history of viral mesenteric adenitis, and case 2 had a history of hand, foot, and mouth disease. For case 3, no previous history of systemic viral infection was established. Snellen visual acuity was 20/20 for all 3 children. The lesion was located superior to the fovea for case 1 and centered to the fovea for cases 2 and 3, all in the left eye. In all 3 patients, hyperautofluorescent changes were noted around the edges of the lesion, which was roughly discoid. OCT showed subtle changes of the interdigitation zone and retinal pigment epithelium (RPE) for cases 1 and 2. In case 3 the presence of hyperreflective, hypertrophic tissue at the level of the interdigitation zone and/or the RPE was noted. CONCLUSIONS In these 3 children with subclinical, unilateral discoid maculopathy sharing common features and identified incidentally, previous viral illness may have been causative. These cases may represent resolved unilateral acute idiopathic maculopathy. (J AAPOS 2020;-:1.e1-6) I n recent years, the number of incidental findings and referrals across all the disciplines of medicine, including ophthalmology, has increased because of screening programs and developments in medical imaging. 1,2 The epidemiological data for incidental findings are limited and difficult to collect, because they involve private practice and public hospitals, optometrist, ophthalmologists, and other disciplines, as well as screening programs and routine checkups. Incidental findings can be benign or malignant, inflammatory, infectious , inherited, or congenital-developmental. We present a case series of 3 children with a benign, unilateral discoid maculopathy, sharing common features, identified incidentally, and referred to a tertiary eye center for further investigation. Methods This study complies with all local laws and the principles of the Declaration of Helsinki and was approved by the Moorfields Eye Hospital Ethics Committee. The patients were examined by medical retina specialists, in Moorfields Eye Hospital, London. All available clinical notes and retinal imaging were reviewed. Further detailed medical history was requested from the caring general practitioners of the children. Results Three children (age range, 4-11 years; 2 female) were referred after presenting to their local optometrist for routine eye examination, with no subjective ophthalmic complaints, on discovery of an unusual left circular macular lesion (Figures 1-3). All 3 children denied any visual disturbanc...

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“…Optical coherence tomography (OCT) is also a useful tool for the diagnosis of ARPE and identification of the primary site of inflammation in ARPE [7][8][9][10][11][12][13]. Currently, rather than the RPE, the outer retinal layer, especially including the interdigitation zone (IZ), ellipsoid zone (EZ), and external limiting membrane (ELM), is considered the mainstay of inflammation in ARPE [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Acute Retinal Pigment Epitheliitis following Vaccination

Sasajima¹,

Zako²,

Aoyagi³

et al. 2022

Case Rep Ophthalmol

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We present a rare case of acute retinal pigment epitheliitis (ARPE) following vaccination. An 18-year-old Japanese man visited our hospital with a 5-day history of a central scotoma in the right eye. He had received the second dose of coronavirus disease 2019 vaccination (BNT162b2 mRNA, Pfizer-BioNTech) 1 month prior, following which he developed a low-grade fever of 37.3–37.5°C for 2 days accompanied by joint pain. Although he had received influenza vaccination 5 days prior to this presentation, no systemic symptoms other than injection site pain were observed. Blood test results were unremarkable. Ophthalmological examination revealed a decimal best-corrected visual acuity (BCVA) of 0.8 and 1.2 in the right and left eyes, respectively. Intraocular pressure was 15 mm Hg in both eyes. Intraocular inflammation was not observed. Fundus examination revealed a localized lesion of pigment stippling associated with yellowish hypopigmentation in the fovea. Fluorescein angiography revealed slight transmission hyperfluorescence without leakage. Optical coherence tomography (OCT) revealed disruption of the external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ). We diagnosed the patient with ARPE in the right eye. The patient was followed up without treatment. Five weeks after onset, the central scotoma in the right eye disappeared, and patient’s BCVA in the right eye improved to 1.5. OCT showed improvement in ELM and EZ continuity in the right eye, but IZ remained disruptive. Although the exact pathophysiology of the association between ARPE and these vaccinations is unclear, ARPE may develop after the vaccination.

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Spectral-Domain Optical Coherence Tomography Findings in Acute Retinal Pigment Epitheliitis

Cited by 10 publications

References 9 publications

Acute Fovealitis

Acute Fovealitis

Incidental unilateral idiopathic maculopathy in children

Acute Retinal Pigment Epitheliitis following Vaccination

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