Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals

Armario, Antonio; Escorihuela, Rosa M.; Nadal, Roser

doi:10.1016/j.neubiorev.2008.04.003

Cited by 138 publications

(104 citation statements)

References 136 publications

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“…Although the long-term effects of a single exposure to severe stressors on the ASR are not always consistent (see Armario et al, 2008 for a review), the observed increase is in accordance with some previous studies using other stress models of presumably high severity (e.g., Cohen et al, 2005;Khan and Liberzon, 2004;Servatius et al, 1995).…”

Section: Accepted M Manuscriptsupporting

confidence: 89%

Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats

Fuentes

Carrasco

Armario

et al. 2014

Hormones and Behavior

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Exposure to stress during childhood and adolescence increases vulnerability to developing several psychopathologies in adulthood and alters the activity of the hypothalamic-pituitaryadrenal (HPA) axis, the prototypical stress system. Rodent models of juvenile stress appear to support this hypothesis because juvenile stress can result in reduced activity/exploration and enhanced anxiety, although results are not always consistent. Moreover, an in-depth characterization of changes in the HPA axis is lacking. In the present study, the long-lasting effects of juvenile stress on adult behavior and HPA function were evaluated in male rats. The juvenile stress consisted of a combination of stressors (cat odor, forced swim and footshock) during postnatal days 23-28. Juvenile stress reduced the maximum amplitude of the adrenocorticotropic hormone (ACTH) levels (reduced peak at lights off), without affecting the circadian corticosterone rhythm, but other aspects of the HPA function (negative glucocorticoid feedback, responsiveness to further stressors and brain gene expression of corticotrophin-releasing hormone and corticosteroid receptors) remained unaltered. The behavioral effects of juvenile stress itself at adulthood were modest (decreased activity in the circular corridor) with no evidence of enhanced anxiety. Imposition of an acute severe stressor (immobilization on boards, IMO) did not increase anxiety in control animals, as evaluated one week later in the elevated-plus maze (EPM), but it potentiated the acoustic startle response (ASR). However, acute IMO did enhance anxiety in the EPM, in juvenile stressed rats, thereby suggesting that juvenile stress sensitizes rats to the effects of additional stressors.

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Section: Accepted M Manuscriptsupporting

confidence: 89%

Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats

Fuentes

Carrasco

Armario

et al. 2014

Hormones and Behavior

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“…Gesi et al [39] reported a marked increase of the cortisol levels in response to stressful stimuli such as noise or high ambient temperature that activated the hypothalamic pituitary adrenal axis leading to a release of ACTH. Similarly, other researchers [11,40] stated that immobilization stress response-related disorders resulted in the hypersecretion of both ACTH and corticosterone to a subsequent stressor.…”

Section: Discussionmentioning

confidence: 87%

Light and electron microscopic study on the effect of immobilization stress on adrenal cortex of adult rats and possible ameliorative role of vitamin E.

Altayeb

Salem

2017

Journal of Medical Histology

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Background: Modern society is full of stress. Immobilization stress is a model used in animals to study its effects. Vitamin E is an antioxidant that protects biological membranes from oxidative stress. Objectives: This study aimed to investigate the effects of immobilization stress on the adrenal cortex of rats and the ameliorative effect of vitamin E. Materials and Methods: Forty adult male rats were used in this study and were divided equally into 4 groups. Group I: were divided equally into negative and positive controls. Group II: rats received vitamin E at a dose of 40 I.U/kg by gastric tube for 30 days. Group III: rats subjected to immobilization stress 2 hours /day for 30 days. Group IV: rats subjected to immobilization stress 2 hours /day and received 40 I.U/kg of vitamin E for 30 days. Adrenal sections were histologically prepared and examined. Results: Group II was comparable to group IA. Group III revealed zona glomerulosa (ZG) with loss of normal architecture, zona fasciculata (ZF) with multiple cells containing cytoplasmic vacuolations and darkly stained nuclei. By EM ZG cells appeared with accumulations of lipid droplets and lysosomes, irregular nuclear envelopes and chromatin condensation. ZF cells showed numerous lipid droplets and irregular nuclear envelopes. There were significant increases in the mean area of collagen fibers and mean serum cortisol level. Group IV revealed regression of these changes and increase in the mean count of CD44 +ve cells. Conclusions: Immobilization stress exerted deleterious suprarenal cortical changes and vitamin E had an ameliorative effect.

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“…In addition, Igf2-P0 KO mice were more wary of consuming a novel foodstuff 32 ( Fig. 4c) and showed a much greater startle response to a stressful acoustic (120 dB) startle stimulus 33 ( Fig. 4d).…”

Section: Resultsmentioning

confidence: 97%

Placental programming of anxiety in adulthood revealed by Igf2-null models

et al. 2013

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Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals

Cited by 138 publications

References 136 publications

Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats

Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats

Light and electron microscopic study on the effect of immobilization stress on adrenal cortex of adult rats and possible ameliorative role of vitamin E.

Placental programming of anxiety in adulthood revealed by Igf2-null models

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