Long Term Modulation and Control of Neuronal Firing in Excitable Tissue Using Optogenetics

Humphreys, Lawrence; Vicente, José Manuel Ferrández; Fernández, Eduardo

doi:10.1007/978-3-642-21344-1_28

Cited by 1 publication

(2 citation statements)

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“…Current research in this area is focused on studying how best to implement this powerful tool for neural interfaces and on combining it with existing interface technologies. 247,248 Bryson et al have demonstrated “orderly recruitment” of muscles innervated with light-sensitive motoneurons. 247,249–251 In this case, “orderly” refers to concordance with the size principle: the preferential recruitment of smaller muscle units before larger, more easily fatigued units.…”

Section: Future Interfaces: Novel Paradigmsmentioning

confidence: 99%

“…Additionally, optogenetic stimulation of the auditory nerve and retina has been realized, and optogenetic stimulation arrays are being developed for use in a closed-loop neuroprosthetic system. 245,248,252 Implanted nerve cuffs offer a potential method of long-term interface, and they are being investigated in animal studies. 249 Similarly, Steinberg et al and others have begun exploring optogenetics as a therapeutic strategy for improving functional stroke recovery.…”

Section: Future Interfaces: Novel Paradigmsmentioning

confidence: 99%

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The Evolution of Neuroprosthetic Interfaces

Adewole¹,

Serruya

Harris

et al. 2016

Crit Rev Biomed Eng

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The ideal neuroprosthetic interface permits high-quality neural recording and stimulation of the nervous system while reliably providing clinical benefits over chronic periods. Although current technologies have made notable strides in this direction, significant improvements must be made to better achieve these design goals and satisfy clinical needs. This article provides an overview of the state of neuroprosthetic interfaces, starting with the design and placement of these interfaces before exploring the stimulation and recording platforms yielded from contemporary research. Finally, we outline emerging research trends in an effort to explore the potential next generation of neuroprosthetic interfaces.

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