The Evolution of Neuroprosthetic Interfaces

Adewole, Dayo O.; Serruya, Mijail; Harris, Jerome S.; Burrell, Justin C.; Petrov, Dmitriy; Chen, H. Isaac; Wolf, John A.; Cullen, D. Kacy

doi:10.1615/critrevbiomedeng.2016017198

Cited by 57 publications

(49 citation statements)

References 311 publications

(413 reference statements)

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“…More attention has been dedicated to the electrical stimulation parameters of these neurostimulators since they are relatively biocompatible. Nonetheless, further modifications to electrode surfaces, such as cross‐linking polyelectrolyte films, neural stem cell‐seeded electrodes, and fibrin hydrogel coatings, have been tested to varying degrees of efficacy in improving the stimulation, recording, and biocompatibility profiles of neurostimulators …”

Section: Introductionmentioning

confidence: 99%

“…Nonetheless, further modifications to electrode surfaces, such as cross-linking polyelectrolyte films, 88 neural stem cell-seeded electrodes, and fibrin hydrogel coatings, have been tested to varying degrees of efficacy in improving the stimulation, recording, and biocompatibility profiles of neurostimulators. 89 Efforts to improve the biocompatibility of implantable electrodes are ongoing, and range from developing new electrode materials, substrates, and coatings that can enhance electrode longevity and functionality. Classically, implantable electrodes were composed of included tungsten, iridium oxide, tantalum oxide, grapheme, carbon nanotubes, polymers, and hydrogels, with substrates that include silicon, silicon oxide or nitride, silk, Teflon, polyimide, and silicone.…”

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confidence: 99%

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Functional and Histological Effects of Chronic Neural Electrode Implantation

Sahyouni

Chang

Moshtaghi

et al. 2017

Laryngoscope Investig Oto

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ObjectivesPermanent injury to the cranial nerves can often result in a substantial reduction in quality of life. Novel and innovative interventions can help restore form and function in nerve paralysis, with bioelectric interfaces among the more promising of these approaches. The foreign body response is an important consideration for any bioelectric device as it influences the function and effectiveness of the implant. The purpose of this review is to describe tissue and functional effects of chronic neural implantation among the different categories of neural implants and highlight advances in peripheral and cranial nerve stimulation. Data Sources: PubMed, IEEE, and Web of Science literature search. Review Methods: A review of the current literature was conducted to examine functional and histologic effects of bioelectric interfaces for neural implants.ResultsBioelectric devices can be characterized as intraneural, epineural, perineural, intranuclear, or cortical depending on their placement relative to nerves and neuronal cell bodies. Such devices include nerve‐specific stimulators, neuroprosthetics, brainstem implants, and deep brain stimulators. Regardless of electrode location and interface type, acute and chronic histological, macroscopic and functional changes can occur as a result of both passive and active tissue responses to the bioelectric implant.ConclusionA variety of chronically implantable electrodes have been developed to treat disorders of the peripheral and cranial nerves, to varying degrees of efficacy. Consideration and mitigation of detrimental effects at the neural interface with further optimization of functional nerve stimulation will facilitate the development of these technologies and translation to the clinic.Level of Evidence3.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Functional and Histological Effects of Chronic Neural Electrode Implantation

Sahyouni

Chang

Moshtaghi

et al. 2017

Laryngoscope Investig Oto

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“…Surgically implanted neural interfaces for the PNS can be categorized as the following (Fig. 1), starting with the more invasive methods (Adewole et al 2016);…”

Section: Electrode Typesmentioning

confidence: 99%

Peripheral nerve bionic interface: a review of electrodes

Russell

Roche

Chakrabarty

2019

Int J Intell Robot Appl

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“…Intracortical electrodes are inserted within the cortex, providing the highest spatial and temporal resolution, allowing the acquisition of single units (i.e., action potential of an individual neuron) and field potential (i.e., spatially integrated action potentials from several neurons) . Different type of electrodes can be used at this location such as flat shanks, shank arrays, platform with fixed electrodes (such as Utah array and FDA approved BrainGate trials) microwires and deep brain stimulation (DBS) electrodes …”

Section: Implantable Neuroprostheses In Clinical Applicationsmentioning

confidence: 99%

“…Comparison among different strategies of stimulation of PNS to evoke tactile percepts. Parameters that have been considered are: i) number of subjects (S) and implant duration; ii) type of implanted electrode, number of channels, nerve target; iii) impedance measurement; iv) type of stimulation pattern; v) threshold charge/current over time; vi) …”

Section: Implantable Neuroprostheses In Clinical Applicationsmentioning

confidence: 99%

Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems

Cutrone

Micera

2019

Adv Healthcare Materials

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functions of nervous system when damages occur. Moreover, in case of physical impairments, the use of artificial tactile sensors is also paramount to ensure the possibility to restore the sense of touch to the patient. Bioinspiration from human natural touch could help in the release of enhanced tactile sensors to be used in neuroprosthetics. Technological and biological advancements brought serious improvements in the quality of these devices, such as miniaturization and increased biocompatibility. This article reviews the essential design criteria, working principles, materials, and technical considerations on neural interfaces and tactile sensors; their clinical application in neuroprosthetics and their future progress toward optimized solutions. Neural InterfacesA neural interface device (NID) is an implantable tool that aims at restoring nervous system functions in case of impairments or communicates with external components (e.g., limb prostheses); its main objective is to record neural signal from a small group of axons/cells or to stimulate a selected area of the nervous system. The clinical potentialities of NIDs range from their applications in central nervous system (CNS) for treating epilepsy seizures, mitigating Parkinson's disease; in peripheral nervous system (PNS) for controlling limb prostheses in amputees and restore sensory feedback; in autonomous nervous system such as vagus nerve to treat drug-resistant epilepsy and chronic depression to finally auditory and vision systems to restore the perception of specific sounds and phosphenes. An ideal NID should be biocompatible, highly selective, low invasive and stable over long time. If intended for clinical applications, the functionality of a NID should be reliable and should last decades. Considering the different implantation sites of interest of the device, various solutions have been proposed to optimize the communication between the NID and the surrounding environment. Figure 1 highlights the main applications of most common used NIDs in neuroprosthetics. With a special focus on implantable neuroprostheses and motor system, this paragraph will portray the design criteria, the materials and technical considerations heretofore used for the development of diverse types of NID used in CNS and PNS.Neuroprosthetics and neuromodulation represent a promising field for several related applications in the central and peripheral nervous system, such as the treatment of neurological disorders, the control of external robotic devices, and the restoration of lost tactile functions. These actions are allowed by the neural interface, a miniaturized implantable device that most commonly exploits electrical energy to fulfill these operations. A neural interface must be biocompatible, stable over time, low invasive, and highly selective; the challenge is to develop a safe, compact, and reliable tool for clinical applications. In case of anatomical impairments, neuroprosthetics is bound to the need of exploring the surrounding environment by fast-responsive and ...

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The Evolution of Neuroprosthetic Interfaces

Cited by 57 publications

References 311 publications

Functional and Histological Effects of Chronic Neural Electrode Implantation

Functional and Histological Effects of Chronic Neural Electrode Implantation

Peripheral nerve bionic interface: a review of electrodes

Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems

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