Long-term moderate magnesium-deficient diet shows relationships between blood pressure, inflammation and oxidant stress defense in aging rats

Blache, Denis; Devaux, Sylvie; Joubert, O.; Loreau, Nadine; Schneider, Martina; Durand, Philippe; Prost, Michel; Gaume, Vincent; Adrian, Markus; Laurant, Pascal; Berthelot, Alain

doi:10.1016/j.freeradbiomed.2006.04.008

Cited by 78 publications

(66 citation statements)

References 46 publications

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“…Routine biochemistry analyses (plasma lipids, lipoproteins, and apolipoproteins) were performed according to standard protocols (25,26). Plasma albumin concentrations were measured by a standard procedure using bromocresol green with human albumin as the standard (27,28).…”

Section: Blood Samplingmentioning

confidence: 99%

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Glycated Albumin With Loss of Fatty Acid Binding Capacity Contributes to Enhanced Arachidonate Oxygenation and Platelet Hyperactivity: Relevance in Patients With Type 2 Diabetes

et al. 2014

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High plasma concentrations of nonesterified fatty acids (NEFAs), transported bound to serum albumin, are associated with type 2 diabetes (T2D). The effects of albumin on platelet function were investigated in vitro. Modifications of albumin, such as those due to glycoxidation, were found in patients with T2D, and the consequences of these modifications on biological mechanisms related to NEFA handling were investigated. Mass spectrometry profiles of albumin from patients with T2D differed from those from healthy control subjects. Diabetic albumin showed impaired NEFA binding capacity, and both structural and functional alterations could be reproduced in vitro by incubating native albumin with glucose and methylglyoxal. Platelets incubated with albumin isolated from patients with T2D aggregated approximately twice as much as platelets incubated with albumin isolated from healthy control subjects. Accordingly, platelets incubated with modified albumin produced significantly higher amounts of arachidonate metabolites than did platelets incubated with control albumin. We concluded that higher amounts of free arachidonate are made available for the generation of active metabolites in platelets when the NEFA binding capacity of albumin is blunted by glycoxidation. This newly described mechanism, in addition to hypoalbuminemia, may contribute to platelet hyperactivity and increased thrombosis, known to occur in patients with T2D.

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Section: Blood Samplingmentioning

confidence: 99%

“…The antioxidant defense of the subjects was examined using a test based on in vitro free radical-induced blood hemolysis (27,30). Fasting blood samples were drawn using 10% (v/v) buffered sodium citrate as the anticoagulant.…”

Section: Antioxidant Statusmentioning

confidence: 99%

Glycated Albumin With Loss of Fatty Acid Binding Capacity Contributes to Enhanced Arachidonate Oxygenation and Platelet Hyperactivity: Relevance in Patients With Type 2 Diabetes

et al. 2014

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“…Magnesium deficiency in rats leads to chromosome breaks (31) and cancer (25). In rats, a diet moderately deficient in magnesium increased mortality, blood pressure, inflammation, and oxidants and decreased resistance to oxidants compared with a standard or magnesium-supplemented diet (32). This evidence suggests that supplementation programs should be considered, because there is little risk of magnesium toxicity (5).…”

Section: Micronutrient Deficiencies May Accelerate Mitochondrial Decamentioning

confidence: 99%

Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage

Ames¹

2006

Proc. Natl. Acad. Sci. U.S.A.

337

231

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Inadequate dietary intakes of vitamins and minerals are widespread, most likely due to excessive consumption of energy-rich, micronutrient-poor, refined food. Inadequate intakes may result in chronic metabolic disruption, including mitochondrial decay. Deficiencies in many micronutrients cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo. Some of these deficiencies also cause mitochondrial decay with oxidant leakage and cellular aging and are associated with late onset diseases such as cancer. I propose DNA damage and late onset disease are consequences of a triage allocation response to micronutrient scarcity. Episodic shortages of micronutrients were common during evolution. Natural selection favors short-term survival at the expense of long-term health. I hypothesize that short-term survival was achieved by allocating scarce micronutrients by triage, in part through an adjustment of the binding affinity of proteins for required micronutrients. If this hypothesis is correct, micronutrient deficiencies that trigger the triage response would accelerate cancer, aging, and neural decay but would leave critical metabolic functions, such as ATP production, intact. Evidence that micronutrient malnutrition increases late onset diseases, such as cancer, is discussed. A multivitamin-mineral supplement is one low-cost way to ensure intake of the Recommended Dietary Allowance of micronutrients throughout life.

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“…16 The hypomagnesaemia found was related to the socioeconomic status in a study from India. 17 Experimental studies have linked hypomagnesaemia with the development of vascular dysfunction, hypertension, and atherosclero- 18,19 Clinical studies limited by the use of self-reported magnesium intake or short followup periods yielded conflicting results. 20,21 However, long term followup clinical studies did not yield similar results.…”

Section: Discussionmentioning

confidence: 99%

Serum magnesium levels in patients with hypertension

Ravi

Usha

2014

J Clin Sci Res

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Long-term moderate magnesium-deficient diet shows relationships between blood pressure, inflammation and oxidant stress defense in aging rats

Cited by 78 publications

References 46 publications

Glycated Albumin With Loss of Fatty Acid Binding Capacity Contributes to Enhanced Arachidonate Oxygenation and Platelet Hyperactivity: Relevance in Patients With Type 2 Diabetes

Glycated Albumin With Loss of Fatty Acid Binding Capacity Contributes to Enhanced Arachidonate Oxygenation and Platelet Hyperactivity: Relevance in Patients With Type 2 Diabetes

Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage

Serum magnesium levels in patients with hypertension

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