Long-term intake of egg white hydrolysate attenuates the development of hypertension in spontaneously hypertensive rats

Miguel, Marta; López‐Fandiño, Rosina; Ramos, Mercedes; Aleixandre, Amaya

doi:10.1016/j.lfs.2005.11.025

Cited by 71 publications

(49 citation statements)

References 34 publications

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“…The progression of hypertension in these animals is in fact similar to that in humans [20]. Several researchers, including our own research group, have reported that, before arterial blood pressure stabilizes in SHR, there is an initial period in the life of these animals in which this variable clearly increases [21–23]. After this period, the arterial blood pressure in the SHR remained constantly high.…”

Section: Discussionmentioning

confidence: 63%

Long-Term Effect of an AqueousFraxinus excelsiorL. Seed Extract in Spontaneously Hypertensive Rats

López-Carreras

Fernández-Vallinas

Miguel

et al. 2014

International Journal of Hypertension

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The effect of long-term intake of different doses (20, 40, and 60 mg/kg/day) of a Fraxinus excelsior L. seed extract (FESE) on spontaneously hypertensive rats (SHR) was evaluated. Water was used as control and captopril (50 mg/kg/day) was used as positive control. Systolic blood pressure, body weight, and food and liquid intake were registered weekly in SHR. The antioxidant and vascular relaxing properties of FESE were also studied in these animals. The development of hypertension was attenuated in the groups treated with captopril or FESE. The antihypertensive effect was more accentuated in the captopril group than in the FESE groups, and it was paradoxically more accentuated in the groups treated with 20 mg/kg/day or 40 mg/kg/day of FESE than in the group treated with the highest dose of this extract. Body weight gain and food intake increased in the FESE groups. After removing the corresponding antihypertensive treatment, the arterial blood pressure and the body weight of the FESE treated animals returned to control values. In addition, FESE increased plasma antioxidant capacity and decreased plasma and liver malondialdehyde levels. Moreover, acetylcholine relaxation improved in the aorta rings from the FESE treated rats.

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Section: Discussionmentioning

confidence: 63%

Long-Term Effect of an AqueousFraxinus excelsiorL. Seed Extract in Spontaneously Hypertensive Rats

López-Carreras

Fernández-Vallinas

Miguel

et al. 2014

International Journal of Hypertension

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“…In previous works we have described egg peptides with ACE‐inhibitory and/or antihypertensive effects,19–23 some of which also exerted a vasodilator action in conduit arteries from Sprague‐Dawley rats 16. A major haemodynamic mechanism in essential hypertension is an increased peripheral resistance, and resistance vessels control most of the vascular resistance to the blood stream 24, 25.…”

Section: Introductionmentioning

confidence: 99%

Vascular effects of egg white-derived peptides in resistance arteries from rats. Structure-activity relationships

García-Redondo

Roque

Miguel

et al. 2010

J. Sci. Food Agric.

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“…The results showed that OEW did not effectively inhibit ACE, whereas hOEW, at concentrations of 0.05 to 0.80 mg/ml, exhibited ACE inhibition activity in a linear, concentration-dependent manner in the range of 15.02%-39.19% (Figure 4). ACE inhibition activity was previously found in hen egg white hydrolyzate (Miguel et al, 2006;Rao et al, 2012). Short peptides (di-and tri-peptides) were reported to have potent ACE inhibition activity and to be more easily absorbed by the intestinal tract than larger short chain peptides (Matthews & Adibi, 1976).…”

Section: Ace Inhibition Activitymentioning

confidence: 98%

“…Moreover, peptides derived from hydrolysated lysozyme show an increase in antimicrobial activity against both Gram-negative and Gram-positive bacteria (Memarpoor-Yazdi et al, 2012), and the proteolytic fragments of ovalbumin also exhibit antimicrobial activity (Pellegrini, Hülsmeier, Hunziker, & Thomas, 2004). In addition, ACE inhibitor activity was found in protein hydrolysate derived from hen egg white (Miguel, Lopez-Fandino, Ramos, & Aleixandre, 2006;Rao, Rocca-Smith, & Labuza, 2012). Compared with that from other avian species, ostrich egg white is composed of a richer source of proteins.…”

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confidence: 99%

Effects of alkaline hydrolysis and storage conditions on the biological activity of ostrich egg white

Khueychai

Jangpromma

Daduang

et al. 2019

J Food Process Preserv

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This study aimed to improve the biological activity of ostrich egg white (OEW) using alkaline hydrolysis (0.25 M NaOH at 40°C for 8 hr), and studied the effects of packing materials and temperature on biological and physical properties of OEW hydrolysate (hOEW). The results show that alkaline hydrolysis clearly enhanced several biological activities, including ABTS radical scavenging (61.35%), anti‐microbial (51.66% against Bacillus subtilis and 38.58% against Escherichia coli) and anti‐angiotensin converting enzyme activity (39.19%). The hydrolysate maintained biological activities after gastrointestinal digestion and showed non‐toxicity toward human red blood cells. In storage study, the best storage conditions were packing hOEW powder in an Al‐foil‐laminated bag at 4°C, resulting in slightly decreased biological activity after 6 months storage and significantly lower moisture content than plastic zipper bag. Additionally, SEM revealed smooth surfaces of hOEW powder for the best condition, while air pores and bridges were found in the worst conditions. Practical applications The alkaline hydrolysis method (incubation in 0.25 M NaOH at 40°C for 8 hr) used in this study can be used to enhance the antioxidant, antimicrobial, and anti‐ACE inhibition activity of egg white protein. This study also reports the optimal packaging and storage conditions for egg white hydrolysate powder, which are beneficial for maintaining the antioxidant, antimicrobial, and anti‐angiotensin converting enzyme activity as well as the texture of the egg white hydrolysate powder.

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Long-term intake of egg white hydrolysate attenuates the development of hypertension in spontaneously hypertensive rats

Cited by 71 publications

References 34 publications

Long-Term Effect of an AqueousFraxinus excelsiorL. Seed Extract in Spontaneously Hypertensive Rats

Long-Term Effect of an AqueousFraxinus excelsiorL. Seed Extract in Spontaneously Hypertensive Rats

Vascular effects of egg white-derived peptides in resistance arteries from rats. Structure-activity relationships

Effects of alkaline hydrolysis and storage conditions on the biological activity of ostrich egg white

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