Vascular effects of egg white-derived peptides in resistance arteries from rats. Structure-activity relationships

Abstract

These peptides could reduce the vascular resistance and be used as functional ingredients in the prevention and/or treatment of hypertension and other associated disorders.

Vasoactive properties of antihypertensive lactoferrin-derived peptides in resistance vessels: Effects in small mesenteric arteries from SHR rats

“…We for the first time report direct relaxant effects of milk protein derived peptides in small distal mesenteric arteries from hypertensive rats, which have a predominant role in the regulation of blood pressure through the control of the systemic vascular resistance. Our findings are in line with relaxant effects of different original or modified egg protein derived peptides in canine mesenteric artery [25], hypertensive rat mesenteric artery [26,27], and small distal branches of rat mesenteric artery [28].…”

“…It should be noted that proximal rat and canine mesenteric arteries were used in those studies. Quite interestingly, COX inhibition produced increase instead of reduction of mesenteric artery relaxation induced by different original or modified egg protein derived peptides [25,27,28], thus indicating the involvement of prostanoids with a net relaxant contribution. Therefore, the role of COX products in mesenteric artery relaxation seems to depend on the peptide sequence/source, the proximal or distal artery level and the animal species, as well as on its normotensive or hypertensive state.…”

Food‐Originating ACE Inhibitors, Including Antihypertensive Peptides, as Preventive Food Components in Blood Pressure Reduction

“…Once the peptide passes through the small intestine, it reaches the large intestine. Then, most of the absorption takes place in the half of the colon defined as the “absorbing colon” (Garcia‐Redondo and others ).…”

Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

“…Several studies have shown beneficial effects of bioactive peptides derived from dietary proteins on endothelial dependent vascular responses. In this sense, we have previously reported endothelium‐dependent vasodilator responses induced by bioactive peptides derived from egg proteins (Garcia‐Redondo, Roque, Miguel, Lopez‐Fandino, & Salaices, ; Miguel et al, ). In addition, several experimental and clinical studies have also found improvement of vasodilator function using bioactive peptides from milk proteins in different conditions (Ballard et al, ; Sipola et al, ).…”