Long-Term Ingestion of Dietary Diacylglycerol Lowers Serum Triacylglycerol in Type II Diabetic Patients with Hypertriglyceridemia

Abstract

We examined the effect of daily consumption of dietary diacylglycerol (DG) oil on serum lipid concentrations in patients with diabetes whose serum triacylglycerol (TG) levels were persistently increased despite continuous nutritional counseling at the outpatient clinic. Patients (n = 16) were divided into DG and control groups (n = 8 each). DG was incorporated (target dose 10 g/d) by substituting DG oil (80 g DG/100 g oil) for the ordinary TG cooking oil used at home for 12 wk. The control group continued consuming ordinary TG cooking oil. Dietary records indicated that there were no differences between groups in total energy intake or percentage of energy from fat. In the DG group, TG intake decreased from 26.8 +/- 9.3 to 15.7 +/- 8.9 g/d, whereas DG intake increased from 0.3 +/- 0.1 to 10.6 +/- 3.9 g/d. No differences between groups were observed in body weight, total fat intake or total oil consumption throughout the study period. In the DG group, serum TG levels decreased 39.4% from 2.51 +/- 0.75 mmol/L to 1.52 +/- 0.28 mmol/L. Serum glycohemoglobin A(1c) (HbA(1c)) concentration also decreased 9.7%. In contrast, there were no changes in these variables in the control group. Serum total and HDL cholesterol were not affected in either group. These results indicate that DG oil may be useful as an adjunct to the standard diet therapy of fat restriction in the management of diabetics with hypertriglyceridemia.

Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance

“…This result is consistent with several studies of chronic DAG consumption, from 4 to 24 weeks duration, in normal subjects (36)(37)(38)(39). However, in patients with T2DM, Yamamoto et al (51) found a significant reduction in fasting TG from baseline after 12 weeks of a DAG-enriched diet compared with a TAG-based diet. These same authors confirmed that finding in a more recent study of patients with diabetes (49).…”

Comparisons of Glucose and Lipid Metabolism in Rats Fed Diacylglycerol and Triacylglycerol Oils

“…Yamamoto et al (34) reported that the serum concen trations of triacylglycerol and glycohemogloblin A1C were reduced by substituting DG oil (10g/d) for TG cooking oil for 12wk in diabetic subjects at the outpa tient clinic, whereas the glucose concentrations were not reduced. They did not show the serum free fatty acid and insulin concentrations.…”

Processing, Manufacturing, Uses and Labelling of Fats in the Food Supply

“…More recently, clinical studies in humans have suggested that the consumption of DAGs compared to triacylglycerols suppressed body weight, altered the composition of fat deposition and reduced postprandial lipidemia [Kunio, 2001;Yamamoto, 2001].…”