Long-term in vivo alterations of polyester vascular grafts in humans

Riepe, G.; Loos, Joachim; Imig, H.; Schröder, A.; Schneider, Erich; Petermann, J.; Rogge, Andreas; Ludwig, Mark A.; Schenke, A.; Nassutt, R.; Chakfé, Nabil; Morlock, Michael M.

doi:10.1016/s1078-5884(97)80062-7

Cited by 112 publications

(56 citation statements)

References 8 publications

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“…The polymer chains may be cleaved at the ester groups resulting in two fragments of carboxylic acid and hydroxyl groups [9,27,28]. Long-term in vivo chemical changes of PET vascular grafts have been attributed to hydrolytic degradation [9].…”

Section: Discussionmentioning

confidence: 99%

“…The vascular graft retrievals studied by Riepe et al [9] were subjected to a pulsatile blood flow environment and shear stress conditions. These factors, which resulted in hydrolytic degradation of vascular grafts, do not describe the environment, loading, and exposure of the Dynesys PET cords, and no in vivo changes in the retrieved PET cords were evident in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…To evaluate the differences, all spectra were normalized to the band of a chemically stable aromatic group at 725 cm -1 and compared with the spectra of non-implanted controls. To evaluate potential hydrolytic degradation, the carboxyl index that is defined as the absorbance ratio of the carboxylic acid (1,640 cm -1 ) to the carbonyl group (1,713 cm -1 ) was calculated [9]. The detection limit of the IR spectroscopy was 5%.…”

Section: Atr-ftir and Gpc Analyses Of Pet Cordsmentioning

confidence: 99%

“…Nevertheless, the biostability of PCU and PET may have been a concern; the literature [8,9] has reported biodegradation of PCU material at 20 weeks in an animal model and long-term in vivo chemical changes of PET.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

In vivo biostability of polymeric spine implants: retrieval analyses from a United States investigational device exemption study

Shen¹,

Zhang²,

Koettig

et al. 2011

Eur Spine J

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The Dynesys System for stabilizing the lumbar spine was first surgically implanted in Europe in 1994. In 2003, a prospective, randomized, investigational device exemption clinical trial of the system for non-fusion dynamic stabilization began. Polycarbonate urethane (PCU) and polyethylene terephthalate (PET) components explanted from four patients who had participated in the study were analyzed for biostability. Components had been implanted 9-19 months. The explanted components were visually inspected and digitally photographed. Scanning electron microscopy was used to analyze the surface of the spacers. The chemical and molecular properties of the retrieved spacers and cords were quantitatively compared with lot-matched, shelf-aged, components that had not been implanted using attenuated total reflection Fourier transform infrared (FTIR) and gel permeation chromatography (GPC). FTIR analyses suggested that the explanted spacers exhibited slight surface chemical changes but were chemically unchanged below the surface and in the center. New peaks that could be attributed to biodegradation of PCU were not observed. The spectral analyses for the cords revealed that the PET cords were chemically unchanged at both the surface and the interior. Peaks associated with the PET biodegradation were not detected. GPC results did not identify changes to the distributions of molecular weights that might be attributed to biodegradation of either PCU spacers or PET cords. The explanted condition of the retrieved components demonstrated the biostability of both PCU spacers and PET cords that had been in vivo for up to 19 months.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Atr-ftir and Gpc Analyses Of Pet Cordsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In vivo biostability of polymeric spine implants: retrieval analyses from a United States investigational device exemption study

Shen¹,

Zhang²,

Koettig

et al. 2011

Eur Spine J

View full text Add to dashboard Cite

show abstract

“…By taking an abdominal circumference of 100 cm, equivalent to a radial diameter of 31.83 cm, and a thickness of the abdominal wall of 0.08 cm, we arrive at a tension strength for the abdominal wall of 20 …”

Section: Tension Strengthmentioning

confidence: 99%

Biocompatibility of Biomaterials - Clinical and Mechanical Aspects

Conze¹,

Klinge²

1999

Incisional Hernia

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Improvement of Bio‐ and Bloodcompatibility of Polymers by PACVD

Breme

Buttstaedt

Emig

et al. 2000

Materials for Medical Engineering

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State of the art applications of polymers in medical implants cause in some cases problems due to their insufficient bio-and bloodcompatibility. On the other hand, titanium based materials are known to have bioinert properties.In order to combine the mechanical properties of polymers with the biocompatibility of titanium based materials, a new process for coating polymers with Titaniumcarbonitride(Ti(C,N))-layers by plasma assisted chemical vapor deposition (PACVD) has been developed.The in vitro bio-and bloodcompatibility is improved by the coating compared with uncoated PET and PP. It could be demonstrated that leaching of plasticizers (e. g. from PVC) can be prevented. Moreover PACVD is an excellent technique to obtain even coatings on complex substrates like textile implants.

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Long-term in vivo alterations of polyester vascular grafts in humans

Abstract: Regular follow-ups of patients with aged vascular grafts and the precise documentation of implanted materials are necessary to estimate graft degradation.

Cited by 112 publications

References 8 publications

In vivo biostability of polymeric spine implants: retrieval analyses from a United States investigational device exemption study

In vivo biostability of polymeric spine implants: retrieval analyses from a United States investigational device exemption study

Biocompatibility of Biomaterials - Clinical and Mechanical Aspects

Improvement of Bio‐ and Bloodcompatibility of Polymers by PACVD

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