Long-Term Improvement in Refractory Headache Following Ozone Therapy

Clavo, Bernardino; Santana‐Rodríguez, Norberto; Gutierrez, Dominga; López, Juan Carlos Uribe; Suárez, Gerardo; Mora, Laura; Robaina, Francisco; Bocci, Velio

doi:10.1089/acm.2012.0273

Cited by 21 publications

(19 citation statements)

References 21 publications

(26 reference statements)

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“…In medicine, locally applied ozone has been shown to alleviate painful conditions 18 , 19 , and to reduce inflammatory responses 20 , 21 . So far, however, no prior clinical trial has explored the results of utilizing ozone before H 2 O 2 application in comparison to using ozone after H 2 O 2 application for dental bleaching, and no information is retrievable with regards to prevailing pain sensations due to tooth whitening procedures, a phenomenon called bleaching sensitivity 22 .…”

Section: Introductionmentioning

confidence: 99%

Randomized controlled clinical trial on bleaching sensitivity and whitening efficacy of hydrogen peroxide versus combinations of hydrogen peroxide and ozone

AL‐Omiri

Nazeh

Kielbassa

et al. 2018

Sci Rep

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The clinical efficacy regarding bleaching sensitivity and tooth shade lightening using a standard hydrogen peroxide (H2O2) bleaching gel was compared with the additional use of ozone either before or after application of H2O2. Using computer-generated tables, 45 participants were randomly allocated into three groups (n = 15 each) in this investigator-driven, single-centre trial. In Group 1, upper anterior teeth were bleached using ozone (produced via a healOzone X4 device) for 60 seconds, then 38% H2O2 for 20 minutes; in Group 2, 38% H2O2 application (20 min) was followed by ozone (60 s); air produced by the healOzone machine (60 s) followed by 38% H2O2 (20 min) was used in Group 3 (control). Bleaching sensitivity was evaluated via visual analogue scales, and a treatment-blinded reader objectively recorded tooth shades using a colorimeter before and 24 hours after bleaching (at α = 0.05). The H2O2/ozone combination did not result in pain sensations, while both ozone/H2O2 and H2O2 alone increased bleaching sensitivity (p < 0.001). Teeth achieved lighter shades (higher L*/lower b* values) after bleaching in all groups (p < 0.001), while Ozone boosted lighter tooth shades, irrespective of its use before or after H2O2 (p < 0.05). Due to the complimentary effects, applying ozone after H2O2 seems preferable for bleaching.

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Section: Introductionmentioning

confidence: 99%

Randomized controlled clinical trial on bleaching sensitivity and whitening efficacy of hydrogen peroxide versus combinations of hydrogen peroxide and ozone

AL‐Omiri

Nazeh

Kielbassa

et al. 2018

Sci Rep

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“…The reported number of cases regarding the use of ozone treatment in headache is also very low and no randomized controlled trials are available in the literature. There is a study in five patients stating that ozone therapy was useful in headache (52). However, it is not possible to make a proposal by evaluating the low quality scientific data.…”

Section: Ozone Therapymentioning

confidence: 99%

The Assesment of Efficacy of Traditional and Complementary Medicine Practices in Neurology

Çağlayan¹,

Ataoglu²,

Kibaroğlu³

2018

tnd

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“… 9 It has been demonstrated to be of benefit in treating low back pain from a herniated disk as well as refractory headache. 10 , 11 Multiple mechanisms of action have been proposed to explain the mechanism of percutaneous ozone injection including anti-inflammatory effects and oxidative action on proteoglycans. 12 The use of percutaneous ozone injection in TN has not been thoroughly investigated, to date.…”

Section: Introductionmentioning

confidence: 99%

Computed tomography-guided percutaneous ozone injection of the Gasserian ganglion for the treatment of trigeminal neuralgia

Liu

Chen³

et al. 2018

JPR

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ObjectiveThe aim of this study was to evaluate the therapeutic effect of computed tomography (CT)-guided percutaneous ozone injection for refractory trigeminal neuralgia.DesignA retrospective evaluation was performed in the study.SettingThe study was conducted at a university hospital pain center.Patients and methodsA total of 29 patients with a clinical diagnosis of refractory trigeminal neuralgia were enrolled. All patients were treated with a percutaneous ozone injection and one patient was excluded. There were 21 patients with classical trigeminal neuralgia (group A) and seven patients with painful trigeminal neuropathy caused by post-herpetic neuralgia (group B). The percutaneous injection was an oxygen–ozone mixture at an ozone concentration of 30 μg/mL into the Gasserian ganglion performed under CT guidance. The number of procedures performed varied from one to as many as 16. Outcomes were evaluated using visual analog scale (VAS) pain scores.ResultsThe combined VAS scores were 7.11 ± 1.23 pretreatment, 2.86 ± 1.69 posttreatment (P < 0.05) and 3.25 ± 2.01 after 6-month follow-up (P < 0.05). In group A, the VAS scores were 7.10 ± 1.04 pretreatment and 2.90 ± 1.84 posttreatment (P < 0.05). In group B, the VAS scores were 7.14 ± 1.77 pretreatment and 2.71 ± 1.25 posttreatment (P < 0.05). After 6-months follow-up, the VAS score was 3.38 ± 2.18 in group A and 2.86 ± 1.46 in group B, a decrease compared to pretreatment (P < 0.05). VAS of Group A and B showed no difference not only in pretreatment but also in postreatment and follow-up.ConclusionPercutaneous ozone injection is a safe and effective treatment for patients with refractory trigeminal neuralgia.

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Long-Term Improvement in Refractory Headache Following Ozone Therapy

Abstract: Ozone therapy decreased headache episodes and pain severity over a protracted period. This novel approach is effective and merits further research.

Cited by 21 publications

References 21 publications

Randomized controlled clinical trial on bleaching sensitivity and whitening efficacy of hydrogen peroxide versus combinations of hydrogen peroxide and ozone

Randomized controlled clinical trial on bleaching sensitivity and whitening efficacy of hydrogen peroxide versus combinations of hydrogen peroxide and ozone

The Assesment of Efficacy of Traditional and Complementary Medicine Practices in Neurology

Computed tomography-guided percutaneous ozone injection of the Gasserian ganglion for the treatment of trigeminal neuralgia

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