Long-term improvement by ozone treatment in chronic pain secondary to chemotherapy-induced peripheral neuropathy: A preliminary report

Clavo, Bernardino; Rodríguez-Abreu, Delvys; Galván, Saray; Federíco, M.; Martı́nez-Sánchez, Gregorio; Ramallo-Fariña, Yolanda; Antonelli, C.; Benítez, Gretel; Rey-Baltar, D.; Jorge, Ignacio J; Rodrı́guez-Esparragón, Francisco; Serrano‐Aguilar, Pedro

doi:10.3389/fphys.2022.935269

Cited by 6 publications

(7 citation statements)

References 34 publications

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“…However, in cancer survivors without tumor progression, pain management can become difficult because (i) the use of opioids is controversial due to the side effects and lack of evidence and (ii) a neuropathic component frequently exists, which adds additional difficulties in pain management [28]. The improvement obtained in the "pain or discomfort" domain in this study agrees with our previous experiences with O 3 T in the management of refractory pelvic pain [18,19] and painful chemotherapy-induced peripheral neuropathy [17]. Currently, we are enrolling patients in a RCT for the latter symptom (NCT04299893), and a different RCT is planned for the former (EuraCT 2022-000320-37).…”

Section: Discussionsupporting

confidence: 79%

“…According to the symptoms of the patients, the ozone treatment procedures were focused on (i) a systemic ozone effect, using rectal insufflation, with or without (ii) a local ozone effect, with ozone exposition of the damaged area (cutaneous wounds or intravesical). For ozone insufflations, the O 3 /O 2 concentrations were progressively increased between 10 and 30 µg/mL, as previously described [17]. For topical administration, ozone concentrations usually ranged between 40 and 10 µg/mL, according to patients' tolerance or on the basis of the presence or absence of local infection.…”

Section: Ozone Treatmentmentioning

confidence: 99%

“…However, ozone is not a pharmaceutical drug; it is associated with a therapeutical procedure (health technology), randomized controlled trials (RCT) are difficult to carry out, and there have been almost no RCTs until the current century. We have previously published reports about the beneficial effects of adding ozone treatment to the management of difficult clinical conditions, such as painful CIPN [17], and several refractory radiation-induced pelvic symptoms, such as chronic pain [18,19], hematuria [20], and rectal bleeding [21,22]. Indeed, for the latter condition, O 3 T has been described as having a grade of recommendation 1C in the guidelines for the treatment of chronic radiation proctitis published by the American Society of Colon and Rectal Surgeons [23].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Ozone Treatment on Health-Related Quality of Life and Toxicity Induced by Radiotherapy and Chemotherapy in Symptomatic Cancer Survivors

Clavo

Cánovas-Molina

Ramallo-Fariña

et al. 2023

IJERPH

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(1) Background: The continuous improvement in cancer treatment has led to improvement in patients’ survival and a subsequent increase in the number of cancer survivors living with adverse side effects of cancer treatments, sometimes with a high and adverse impact on their health-related quality of life (HRQOL). Side effects of cancer treatments are frequently associated with chronic status of oxidative stress, inflammation, and/or ischemia. The potential for ozone treatment to modulate those processes and improve some of those adverse effects has previously been described. The aim of this study was to evaluate the effect of ozone treatment on the HRQOL and grade of toxicity in symptomatic cancer survivors. (2) Methods: Before and after ozone treatment, we assessed (i) the HRQOL (according to the EQ-5D-5L questionnaire) and (ii) the grade of toxicity (according to the Common Terminology Criteria for Adverse Events of the National Cancer Institute of EEUU (CTCAE v.5.0)) in 26 cancer survivors with chronic side effects of radiotherapy and chemotherapy. (3) Results: There was a significant (p < 0.001) improvement in the EQ-5D-5L index as per the self-reported outcome evaluation of patients’ health status. All the dimensions of the EQ-5D-5L questionnaire (mobility, self-care, activities, pain/discomfort, and anxiety/depression) and the self-evaluation of the health status using the visual analog scale were significantly improved (p < 0.05). The grade of toxicity was also significantly decreased (p < 0.001). (4) Conclusions: In cancer survivors with chronic side effects of cancer treatment, ozone treatment can improve the grade of toxicity and the HRQOL. These results merit additional research. Further studies are ongoing.

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Section: Discussionsupporting

confidence: 79%

Section: Ozone Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Ozone Treatment on Health-Related Quality of Life and Toxicity Induced by Radiotherapy and Chemotherapy in Symptomatic Cancer Survivors

Clavo

Cánovas-Molina

Ramallo-Fariña

et al. 2023

IJERPH

Self Cite

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“…The other study conducted on seven patients (two males and five females between 36 and 73 years old) with chronic and painful grade II or III level of CIPN revealed significant improvement in all patients except for one after adjuvant treatment with rectal ozone therapy. The median pain score according to the VAS was 7 (range: 5–8) before ozone treatment, 4 (range: 2–6) at the end of ozone treatment ( p = 0.004), 5.5 (range: 1.8–6.3) 3 months later ( p = 0.008), and 6 (range: 2.6–6.6) 6 months later ( p = 0.008) [ 29 ].…”

Section: Ozone Therapy In Cancer Painmentioning

confidence: 99%

Ozone in Chemotherapy-Induced Peripheral Neuropathy—Current State of Art, Possibilities, and Perspectives

Szklener

Rudzińska

Juchaniuk

et al. 2023

IJMS

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Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most detrimental toxicity to a patient’s quality of life. Pathophysiological mechanisms involved in CIPN pathogenesis are complex, multifactorial, and only partially examined. They are suspected to be associated with oxidative stress (OS), mitochondrial dysfunction, ROS-induced apoptosis, myelin sheath and DNA damage, and immunological and inflammatory processes. Unfortunately, medications commonly used for the management of other neuropathic pain syndromes, including gabapentinoids, opioids, and tricyclic antidepressants (such as desipramine and nortriptyline), do not bring satisfactory results in CIPN. The aim of this review is to evaluate the existing literature on the potential use of medical ozone as a treatment for CIPN. This paper would explore the potential therapeutic benefits of medical ozone. The review would evaluate the existing literature on the use of medical ozone in other contexts, as well as its potential application in treating CIPN. The review would also suggest possible research methods, such as randomized controlled trials, to evaluate the efficacy of medical ozone as a treatment for CIPN. Medical ozone has been used to disinfect and treat diseases for over 150 years. The effectiveness of ozone in treating infections, wounds, and a variety of diseases has been well documented. Ozone therapy is also documented to inhibit the growth of human cancer cells and has antioxidative and anti-inflammatory effects. Due to its ability to modulate oxidative stress, inflammation, and ischemia/hypoxia, ozone may have a potentially valuable effect on CIPN.

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“…The production of ROS in turn acts on mitochondria to further aggravate mitochondrial damage, which leads to the aggravation of CIPN. Clavo et al [8] proposed to treat CIPN through antioxidant stress pathway. Patients secondary to grade II or III CIPN pain were treated by rectal ozone blowing.…”

Section: Antioxidant Stressmentioning

confidence: 99%

Research on the Mechanism of Traditional Chinese Medicine in Treating Chemotherapy Induced Peripheral Neuropathy

2023

IJFM

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Chemotherapy-induced peripheral neuropathy (CIPN) is characterized by numbness, paresthesia and hyperalgesia at the extremities. It is a common side effect of tumor therapy and the main cause of tumor treatment failure and poor quality of life. Duloxetine is the only first-line drug recommended by the latest CIPN treatment guidelines, but its efficacy is not ideal. Modern studies show that CIPN pathogenesis is numerous, and the treatment of CIPN is still limited to a single mechanism and the treatment effect is not ideal. Clinical practice observed that Chinese medicine treatment CIPN patients can obviously alleviate pain, and modern pharmacological studies show that Chinese medicine can alleviate CIPN symptoms through a variety of mechanisms, this study on the CIPN protection mechanism and Chinese medicine treatment CIPN mechanism to do a summary.

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Long-term improvement by ozone treatment in chronic pain secondary to chemotherapy-induced peripheral neuropathy: A preliminary report

Cited by 6 publications

References 34 publications

Effects of Ozone Treatment on Health-Related Quality of Life and Toxicity Induced by Radiotherapy and Chemotherapy in Symptomatic Cancer Survivors

Effects of Ozone Treatment on Health-Related Quality of Life and Toxicity Induced by Radiotherapy and Chemotherapy in Symptomatic Cancer Survivors

Ozone in Chemotherapy-Induced Peripheral Neuropathy—Current State of Art, Possibilities, and Perspectives

Research on the Mechanism of Traditional Chinese Medicine in Treating Chemotherapy Induced Peripheral Neuropathy

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