Long-term Impact of Continuous Positive Airway Pressure Therapy on Arrhythmia and Heart Rate Variability in Patients With Sleep Apnea

Grau, Núria; Bazán, Víctor; Kallouchi, Mohamed; Rodríguez, Diego A.; Estirado, Cristina; Corral, Maria Isabel; Valls, María Teresa Pastor; Ramos, Pablo; Sanjuas, Carles; Félez, M A; Vallès, Ermengol; Benito, Begoña; Gea, Joaquim; Bruguera-Cortada, Jordi; Martí‐Almor, Julio

doi:10.1016/j.arbr.2015.11.003

Cited by 5 publications

(3 citation statements)

References 25 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The other studies by Grau et al were carried out after a longer time after initiation of CPAP therapy, that is, after a year of treatment, in a group of 26 individuals and it has been observed that CPAP therapy only partially improved heart rate variability, exclusively during waking hours, simultaneously reducing episodes of atrial tachycardia [ 29 ]. Namely, rMSSD parameter improved and in patients > 50 years old LF and HF parameters from spectral analysis increased.…”

Section: Discussionmentioning

confidence: 99%

The effect of CPAP therapy on heart rate variability in patients with obstructive sleep apnea

Grzęda-Hałon

Poręba

Gut

et al. 2022

Sleep Biol. Rhythms

View full text Add to dashboard Cite

The aim of this study was to analyze the relationship between the initiation of CPAP therapy and HRV in patients with OSA. The study group consisted of 37 patients, aged 34–79 (mean 54.95 years) with OSA treated with CPAP. Two subgroups of patients were distinguished: less than severe (AHI < 30, n = 16) and severe OSA (AHI ≥ 30, n = 21). The second study was carried out around a month after the initiation of therapy. CPAP therapy caused the improvement in polysomnographic parameters, however, in most parameters in time and frequency analysis, there were no significant positive changes in parasympathetic tone. Moreover, in HRV time analysis, the reduced rMSSD and pNN50 parameters in the hours of night rest and rMSSD and SDSD during the 15-min N3 sleep period were noted. Especially, in the group with AHI ≥ 30, we observed significant decreases in rMSSD and pNN50 for the entire time. The changes were mainly for the night periods including the N3 sleep period, which is especially connected with sleep apnea (parameters: rMSSD, SDSD, and pNN50). In spectral analysis, the decrease in HF from the 15-min daily activity period and the N3 sleep period was observed. Inverse correlations were seen between the maximum, median, and mean positive airway pressure (PAP) and the change in rMSSD, SDNN, and SDSD, mainly during night hours and the N3 sleep period. Only in patients with AHI < 30 the increase in SDNN was observed in 15-min N3 sleep period. The beneficial increase in SDNN parameter from time analysis was observed only in one sleep period in less ill patients with OSA. The lack of significant changes was observed in the majority of the parameters of heart rate variability after initiation of CPAP therapy in a short observational time; however, the shift towards reduced HRV was observed in patients with AHI > 30, so the response to CPAP therapy may depends on the severity of the apnea. The results may suggest that a longer observational period is needed in such studies, and the problem is still not fully elucidated.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of CPAP therapy on heart rate variability in patients with obstructive sleep apnea

Grzęda-Hałon

Poręba

Gut

et al. 2022

Sleep Biol. Rhythms

View full text Add to dashboard Cite

show abstract

“…30 In another study using heart rate variability as indices for autonomic tone, CPAP therapy only increased a parasympathetic parameter during wakefulness. 6 It is possible that poor adherence to CPAP underlies these negative findings. However, based on the results of our study, most patients with OSA actually did not have abnormally high SKNA.…”

Section: The Significance Of Skna Recording In Osa Patientsmentioning

confidence: 99%

“…[1][2][3][4] One of the possible mechanisms associated with increased cardiovascular mortality and morbidity is that OSA increases sympathetic tone, as documented by plasma norepinephrine measurements and direct muscle sympathetic nerve activity (MSNA) recording using microneurography techniques. [5][6][7][8] A major limitation of microneurography is the technical difficulty, which limited most of these studies to < 10 total patients. A second limitation of microneurography is a lack of voltage calibration, making it difficult to compare the SNA amplitudes between patients or disease conditions.…”

Section: Introductionmentioning

confidence: 99%