Long-term high frequency transcutaneous electrical nerve stimulation (hi-TNS) in chronic pain. Clinical response and effects on CSF-endorphins, monoamine metabolites, substance P-like immunoreactivity (SPLI) and pain measures

Almay, B. G. L.; Johansson, Folke; Knorring, Lars von; Sakurada, Tsukasa; Terenius, Lars

doi:10.1016/0022-3999(85)90051-0

Cited by 30 publications

(14 citation statements)

References 33 publications

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“…The phenomenon was suggested to be effective via multiple mechanisms [12,19,20,23,24]. One popular proposed mechanism is the Gate Control Theory of Pain [25], which proposes that stimulation of large-diameter afferent fibers can inhibit the transmission of nociceptive information, in the dorsal horn, to higher brain centers.…”

Section: Discussionmentioning

confidence: 99%

“…Literature reviews have documented the efficacy of some of these analgesics [5,8,9], but reveal conflicting results for others [10,11]. For example, TENS is used in a variety of clinical settings to treat different painful conditions [12-15]. However, the clinical effectiveness of TENS is controversial, with some studies supporting and others refuting its clinical use [11,16].…”

Section: Introductionmentioning

confidence: 99%

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Immediate and short-term pain relief by acute sciatic nerve press: a randomized controlled trial

Zhang³

et al. 2007

BMC Anesthesiol

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BackgroundDespite much research, an immediately available, instantly effective and harmless pain relief technique has not been discovered. This study describes a new manipulation: a "2-minute sciatic nerve press", for rapid short-term relief of pain brought on by various dental and renal diseases.MethodsThis randomized, single-blind, placebo-controlled trial ran in three hospitals in Anhui Province, China, with an enrollment of 66 out of 111 solicited patients aged 16 to 74 years. Patients were recruited sequentially, by specific participating physicians at their clinic visits to three independent hospitals. The diseases in enrolled dental patients included dental caries, periodontal diseases and dental trauma. Renal diseases in recruits included kidney infections, stones and some other conditions. Patients were randomly assigned to receive the "2-minute sciatic nerve press" or the "placebo press". For the "2-minute sciatic nerve press", pressure was applied simultaneously to the sciatic nerves at the back of the thighs, using the fists while patients lay prone. For the "placebo press", pressure was applied simultaneously to a parallel spot on the front of the thighs, using the fists while patients lay supine. Each fist applied a pressure of 11 to 20 kg for 2 minutes, after which, patients arose to rate pain.ResultsThe "2-minute sciatic nerve press" produced greater pain relief than the "placebo press". Within the first 10 minutes after sciatic pressure, immediate pain relief ratings averaged 66.4% (p < 0.001) for the dental patients, versus pain relief of 20% for the placebo press, and, 52.2% (p < 0.01) for the renal patients, versus relief of 14% for the placebo press, in median. The method worked excellently for dental caries and periodontal diseases, but poorly for dental trauma. Forty percent of renal patients with renal colic did not report any pain relief after the treatment.ConclusionTwo minutes of pressure on both sciatic nerves can produce immediate significant conduction analgesia, providing a convenient, safe and powerful way to overcome clinical pain brought on by dental diseases and renal diseases for short term purposes.Trial registrationACTR 12606000439549

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immediate and short-term pain relief by acute sciatic nerve press: a randomized controlled trial

Zhang³

et al. 2007

BMC Anesthesiol

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“…Several studies have indicated disturbances of CSF opiopeptides in neurogenic pain (Almay et al 1985, Nvberg et al 1988, Grond 1992). Thus, patients suffering from neurogenic pain have decreased levels of so-called fraction I endorphins (Almay et al 1985).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, patients suffering from neurogenic pain have decreased levels of so-called fraction I endorphins (Almay et al 1985). Fraction I represents a pool of opioid-active CSF peptides, most of which seem to be derived from the prodynorphin system (Nyberg et al 1983).…”

Section: Discussionmentioning

confidence: 99%