CSF Opioids in Pathophysiology

Neuropeptide-converting enzymes in cerebrospinal fluid:Activities increased in pain from herniated lumbar disc, but not from coxarthrosis

“…Opioid peptides and substance P have been evaluated in the cerebrospinal fluid (CSF) collected from patients with depression and with different types of chronic pain (for review, see Nyberg et al 1988). Variations in the levels of CSF endorphins and/or subsiance P have been reported in many conditions, such as chronic lumbar disc pain, chronic organic neurogenic pain and migraine (Nyberg 1993).…”