Long-term graft survival after penetrating keratoplasty

Thompson, Robert W.; Price, Marianne O.; Bowers, Patrick; Price, Francis W.

doi:10.1016/s0161-6420(03)00463-9

Cited by 527 publications

(338 citation statements)

References 29 publications

Supporting

Mentioning

299

Contrasting

Unclassified

Order By: Relevance

“…1 Unfortunately however, graft failure remains a problem with 18% of primary grafts failing within 10 years. 2 The commonest reasons for graft failure are endothelial rejection and chronic endothelial cell loss. 2,3 Anterior lamellar keratoplasty reduces rejection rates by preserving the patient's own endothelial cells.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative cohort study of the outcomes of deep lamellar keratoplasty and penetrating keratoplasty for keratoconus

Funnell

Ball

Noble

2005

Eye

158

104

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…2 The commonest reasons for graft failure are endothelial rejection and chronic endothelial cell loss. 2,3 Anterior lamellar keratoplasty reduces rejection rates by preserving the patient's own endothelial cells. Unfortunately, visual results have been disappointing due to interface scarring.…”

Section: Introductionmentioning

confidence: 99%

Comparative cohort study of the outcomes of deep lamellar keratoplasty and penetrating keratoplasty for keratoconus

Funnell

Ball

Noble

2005

Eye

158

104

View full text Add to dashboard Cite

show abstract

“…50,59,60 In a study by Thompson and associates the presence of deep vessels in recipient cornea was associated with a low (65% 10-year survival) compared to those without vascularization (85% 10-year survival). 52 In Australian Graft Registry the eyes that were never inflamed had a better 5-year survival (91.3%) compared to 54.2% in eyes that were inflamed in the past. 60 Keratoplasty is considered a high-risk procedure in the paediatric age group.…”

Section: Outcome Of Penetrating Keratoplastymentioning

confidence: 96%

“…Table 7 shows the outcome of keratoplasty based on published reports from both established and less developed economies. [50][51][52][53][54][55][56][57][58][59] Dandona and associates analysed 1-, 2-, and 5-year survival rates of 1725 corneal transplants performed at a tertiary eye care center in India. 58 The survival rates were 79.6% (95% CI 77.…”

Section: Outcome Of Penetrating Keratoplastymentioning

confidence: 99%

The value of corneal transplantation in reducing blindness

Garg

Krishna

Stratis

et al. 2005

Eye

122

View full text Add to dashboard Cite

Purpose To analyse the role of keratoplasty in reducing world blindness due to corneal diseases. Methods Review of published literature. We collected and analysed articles published in the English language literature related to the prevalence and causes of blindness in different parts of the world, causes of corneal blindness, and outcome of corneal transplantation for various corneal diseases. Results A total of 80% of the world's blind live in developing countries. Retinal diseases are the most important causes of blindness (40-54%) in established economy nations while cataract (44-60%) and corneal diseases (8-25%) are the most common causes of blindness in countries with less developed economies. Keratitis during childhood, trauma, and keratitis during adulthood resulting in a vascularized corneal scar and adherent leucoma are the most frequent causes of corneal blindness in developing countries. Corneal diseases are responsible for 20% of childhood blindness. Nearly 80% of all corneal blindness is avoidable. The outcome of keratoplasty for vascularized corneal scar and adherent leucoma is unsatisfactory, necessitating repeat surgery in a high proportion of these cases. Other barriers for keratoplasty in these nations are suboptimal eye banking, lack of trained human resources, and infrastructure. Conclusions Since the developing world carries most of the load of corneal blindness and the major causes of corneal blindness are corneal scar and active keratitis, development of corneal transplantation services need a comprehensive approach encompassing medical standards in eye banking, training of cornea specialists and eye banking personnel and exposure of ophthalmologists to care of corneal transplants for better follow-up care. However, concerted efforts should be made to develop and implement prevention strategies since most corneal blindness is preventable.

show abstract

“…This high success rate may be partially explained by the lack of both lymphatics and blood vessels in the cornea (Ambati et al 2006;Albuquerque et al 2009). However, after high-risk corneal transplantation involving the presence of at least two quadrants of stromal vascularization and/or a history of graft rejection, the graft survival rate declines significantly to below 50%, despite local and systemic immunosuppression (Maguire et al 1994; Thompson et al 2003). In the vascularized cornea, there is parallel growth of both blood vessels and lymphatics.…”

Section: Introductionmentioning

confidence: 99%

Suppression of Allograft Rejection with Soluble VEGF Receptor 2 Chimeric Protein in a Mouse Model of Corneal Transplantation

Hayashi

Usui

Yamagami

2016

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

When a transparent cornea becomes opaque due to infectious diseases, trauma, or ophthalmic surgery, the impaired cornea is replaced with a donor cornea to improve visual function. In this corneal transplantation, the graft survival rate is comparatively high, partly because of lacking vascular and lymphatic vessel in cornea. However, the transplanted corneas sometimes become opaque if allograft rejection occurs. Suppression of allograft rejection is critical for favorable outcomes of corneal transplantation. The essential effects of endogenous monomeric soluble vascular endothelial growth factor receptors (VEGFRs) 1 and 2 have been reported in corneal angiogenesis and lymphangiogenesis. This study investigated the effects of dimeric soluble VEGFR2/Fc chimera protein on corneal allograft rejection for future clinical application. Allogeneic full-thickness corneal transplantation was performed in C57BL/6 to BALB/c mice. The recipients were treated by intrastromal injection of soluble VEGFR1/Fc chimera (sR1/Fc group), soluble VEGFR2/Fc chimera (sR2/Fc group), or human IgG1/Fc protein (IgG/Fc group) at 0, 7, and 14 days after surgery. Both hemangiogenesis and lymphangiogenesis were significantly suppressed in the corneas of the sR2/Fc group compared with the IgG/Fc group. All grafts failed due to corneal wound rupture in the sR1/Fc group. In the sR2/Fc group, respective donor-derived MHC class II + /CD11c + cells and CD11b-positive macrophage infiltration were reduced in the DLNs and the corneas showing a negative delayed-type hypersensitivity, compared with the IgG/Fc group. Our findings demonstrate that soluble VEGFR2/Fc chimera protein efficiently suppresses corneal allo-rejection, while reducing hemangiogenesis and lymhangiogenesis, and immune-competent cell-trafficking and may be a powerful tool for corneal allograft survival.

show abstract

Long-term graft survival after penetrating keratoplasty

Cited by 527 publications

References 29 publications

Comparative cohort study of the outcomes of deep lamellar keratoplasty and penetrating keratoplasty for keratoconus

Comparative cohort study of the outcomes of deep lamellar keratoplasty and penetrating keratoplasty for keratoconus

The value of corneal transplantation in reducing blindness

Suppression of Allograft Rejection with Soluble VEGF Receptor 2 Chimeric Protein in a Mouse Model of Corneal Transplantation

Contact Info

Product

Resources

About