Long-term global and regional brain volume changes following severe traumatic brain injury: A longitudinal study with clinical correlates

Sidaros, Annette; Skimminge, Arnold; Liptrot, Matthew G.; Sidaros, Karam; Engberg, Aase W.; Herning, Margrethe; Paulson, Olaf B.; Jernigan, Terry L.; Rostrup, Egill

doi:10.1016/j.neuroimage.2008.08.030

Cited by 195 publications

(224 citation statements)

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“…Volumetric analysis using specific regions has demonstrated significant decreases in volume in both adult (Tomaiuolo et al, 2004;Warner et al, 2010a;Wilde et al, 2004Wilde et al, , 2006a and pediatric (Beauchamp et al, 2010;Fearing et al, 2008;Spanos et al, 2007;Wilde et al, 2005Wilde et al, , 2006bWilde et al, , 2007Wu et al, 2010a) subjects with TBI in the chronic post-injury interval. Additionally, voxel-based, whole-surface based, and tensorbased analyses have also demonstrated significant global reductions in cortical thickness (Merkley et al, 2008) and cortical gray matter volume Ding et al, 2008;Gale et al, 2005;Warner et al, 2010a,b) as well as white matter volume (Ding et al, 2008;Sidaros et al, 2009;Vannorsdall et al, 2010). Late volumetric measures have demonstrated relation to measures of clinical severity Schonberger et al, 2009;Trivedi et al, 2007), outcome, (Ding et al, 2008;Gale and Prigatano, 2010;Warner et al, 2010b), cognition (Bergeson et al, 2004;Fujiwara et al, 2008;Himanen et al, 2005;Serra-Grabulosa et al, 2005;Tomaiuolo et al, 2004;Warner et al, 2010a), and potential for benefit from rehabilitation intervention (Strangman et al, 2010), although other studies have reported no correlation between volumetric measures and functional outcome (Anderson et al, 1995;Sherer et al, 2006;Yount et al, 2002).…”

Section: Mrimentioning

confidence: 99%

“…First, volumetric changes can evolve over an extended time (Sidaros et al, 2009;Trivedi et al, 2007;Wu et al, 2010a) and may be evident later than changes seen on other advanced imaging techniques such as DTI (Bendlin et al, 2008;Groen et al, 2010;Hutchinson et al, 2010;Wu et al, 2010a). It should be kept in mind that the relation between tissue integrity, as measured by volumetry, and outcome may be dynamic and complex, particularly in the earlier phases of recovery, as trajectories of rapid cognitive recovery and incomplete degenerative tissue change may be progressing in opposing directions and to differing degrees.…”

Section: Mrimentioning

confidence: 99%

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Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Hunter

Wilde

Tong

et al. 2012

Journal of Neurotrauma

113

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This article identifies emerging neuroimaging measures considered by the inter-agency Pediatric Traumatic Brain Injury (TBI) Neuroimaging Workgroup. This article attempts to address some of the potential uses of more advanced forms of imaging in TBI as well as highlight some of the current considerations and unresolved challenges of using them. We summarize emerging elements likely to gain more widespread use in the coming years, because of 1) their utility in diagnosis, prognosis, and understanding the natural course of degeneration or recovery following TBI, and potential for evaluating treatment strategies; 2) the ability of many centers to acquire these data with scanners and equipment that are readily available in existing clinical and research settings; and 3) advances in software that provide more automated, readily available, and cost-effective analysis methods for large scale data image analysis. These include multi-slice CT, volumetric MRI analysis, susceptibility-weighted imaging (SWI), diffusion tensor imaging (DTI), magnetization transfer imaging (MTI), arterial spin tag labeling (ASL), functional MRI (fMRI), including resting state and connectivity MRI, MR spectroscopy (MRS), and hyperpolarization scanning. However, we also include brief introductions to other specialized forms of advanced imaging that currently do require specialized equipment, for example, single photon emission computed tomography (SPECT), positron emission tomography (PET), encephalography (EEG), and magnetoencephalography (MEG)/magnetic source imaging (MSI). Finally, we identify some of the challenges that users of the emerging imaging CDEs may wish to consider, including quality control, performing multi-site and longitudinal imaging studies, and MR scanning in infants and children.

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Section: Mrimentioning

confidence: 99%

Section: Mrimentioning

confidence: 99%

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Hunter

Wilde

Tong

et al. 2012

Journal of Neurotrauma

113

View full text Add to dashboard Cite

show abstract

“…MRI‐based morphometry has revealed altered cortical thickness and volume within individuals who have sustained a TBI (Bendlin et al., 2008; Gale, Baxter, Roundy, & Johnson, 2005; Kim et al., 2008; Sidaros et al., 2009; Spitz et al., 2013; Tate et al., 2014; Turken et al., 2009; Warner et al., 2010; Zhou et al., 2013). These altered cortical morphometric properties are frequently associated with functional deficits (Gale et al., 2005; Palacios et al., 2013; Sidaros et al., 2009; Spitz et al., 2013; Warner et al., 2010; Zhou et al., 2013), and correspondences between MRI‐based and histological morphometric data of TBI individuals have been reported (Maxwell, MacKinnon, Stewart, & Graham, 2009). RsFC MRI measures the temporal coherency of blood oxygenation level‐dependent (BOLD) signal at rest and it allows us to identify how the brain's intrinsic functional networks are organized (see van Dijk et al., 2010 for review).…”

Section: Introductionmentioning

confidence: 99%

Strategy‐based reasoning training modulates cortical thickness and resting‐state functional connectivity in adults with chronic traumatic brain injury

et al. 2017

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IntroductionPrior studies have demonstrated training‐induced changes in the healthy adult brain. Yet, it remains unclear how the injured brain responds to cognitive training months‐to‐years after injury.MethodsSixty individuals with chronic traumatic brain injury (TBI) were randomized into either strategy‐based (N = 31) or knowledge‐based (N = 29) training for 8 weeks. We measured cortical thickness and resting‐state functional connectivity (rsFC) before training, immediately posttraining, and 3 months posttraining.ResultsRelative to the knowledge‐based training group, the cortical thickness of the strategy‐based training group showed diverse temporal patterns of changes over multiple brain regions (p vertex < .05, p cluster < .05): (1) increases followed by decreases, (2) monotonic increases, and (3) monotonic decreases. However, network‐based statistics (NBS) analysis of rsFC among these regions revealed that the strategy‐based training group induced only monotonic increases in connectivity, relative to the knowledge‐based training group (|Z| > 1.96, pNBS < 0.05). Complementing the rsFC results, the strategy‐based training group yielded monotonic improvement in scores for the trail‐making test (p < .05). Analyses of brain–behavior relationships revealed that improvement in trail‐making scores were associated with training‐induced changes in cortical thickness (p vertex < .05, p cluster < .05) and rsFC (p vertex < .05, p cluster < .005) within the strategy‐based training group.ConclusionsThese findings suggest that training‐induced brain plasticity continues through chronic phases of TBI and that brain connectivity and cortical thickness may serve as markers of plasticity.

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“…Extensive axonal degeneration (Bigler, 1987;Ding et al, 2008;Mamere et al, 2009) and generalized cerebral atrophy (MacKenzie et al, 2002;Sidaros et al, 2009;Trivedi et al, 2007) associated with poor functional outcomes are the common sequelae. TBI-induced hypoperfusion, which could occur beyond the site of primary injury (Bonne et al, 2003;Hofman et al, 2001;Pasco et al, 2007), aggravates this trauma-triggered brain damage.…”

Section: Introductionmentioning

confidence: 99%

Transplantation of Marrow Stromal Cells Restores Cerebral Blood Flow and Reduces Cerebral Atrophy in Rats with Traumatic Brain Injury: In vivo MRI Study

Jiang

et al. 2011

Journal of Neurotrauma

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Cell therapy promotes brain remodeling and improves functional recovery after various central nervous system disorders, including traumatic brain injury (TBI). We tested the hypothesis that treatment of TBI with intravenous administration of human marrow stromal cells (hMSCs) provides therapeutic benefit in modifying hemodynamic and structural abnormalities, which are detectable by in vivo MRI. hMSCs were labeled with superparamagnetic iron oxide (SPIO) nanoparticles. Male Wistar rats (300-350 g, n = 18) subjected to controlled cortical impact TBI were intravenously injected with 1 mL of saline (n = 9) or hMSCs in suspension (n = 9, approximately 3 · 10 6 SPIO-labeled hMSCs) 5 days post-TBI. In vivo MRI measurements consisting of cerebral blood flow (CBF), T2-weighted imaging, and 3D gradient echo imaging were performed for all animals 2 days post-TBI and weekly for 6 weeks. Functional outcome was evaluated with modified neurological severity score and Morris water maze test. Cell engraftment was detected in vivo by 3D MRI and confirmed by double staining. Ventricle and lesion volumetric alterations were measured using T2 maps, and hemodynamic abnormality was tracked by MRI CBF measurements. Our data demonstrate that treatment with hMSCs following TBI diminishes hemodynamic abnormalities by early restoration and preservation of CBF in the brain regions adjacent to and remote from the impact site, and reduces generalized cerebral atrophy, all of which may contribute to the observed improvement of functional outcome.

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Long-term global and regional brain volume changes following severe traumatic brain injury: A longitudinal study with clinical correlates

Cited by 195 publications

References 30 publications

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Strategy‐based reasoning training modulates cortical thickness and resting‐state functional connectivity in adults with chronic traumatic brain injury

Transplantation of Marrow Stromal Cells Restores Cerebral Blood Flow and Reduces Cerebral Atrophy in Rats with Traumatic Brain Injury: In vivo MRI Study

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