Long‐term follow up of serum pepsinogens in patients with gastric cancer or dysplasia after Helicobacter pylori eradication

Noh, Gitark; Kim, Nayoung; Choi, Yonghoon; Lee, Hye Seung; Hwang, Young Jin; Kim, Hee Jin; Yoon, Hyuk; Shin, Cheol Min; Park, Young Soo; Lee, Dong Hoon

doi:10.1111/jgh.15017

Cited by 10 publications

(5 citation statements)

References 49 publications

(81 reference statements)

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“…Previous studies have shown that increased PG II levels are more specific for detecting active H. pylori infection than PG I levels [ 18 ], and PG I levels increase frequently due to drugs, including aspirin [ 19 ]. Differences in serum PG values between the eradicated and non-infected subjects were not detected at ≥24 months after successful eradication [ 20 ]. High serum PG I and PG II levels indicate hyperchlorhydric stomachs [ 21 ], whereas low serum PG I levels and PG I/II ratios indicate hypochlorhydric stomachs with extensive atrophy [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Incidence of Infection among Subjects with Helicobacter pylori Seroconversion

et al. 2022

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Background/Aims: Helicobacter pylori (H. pylori) seroconversion may occur during screening for gastric cancer. Our study aimed to assess the number of seroconverted subjects with H. pylori and their results in follow-up tests.Methods: Data were consecutively collected on subjects who were H. pylori-seronegative and presented for gastric cancer screening. Subjects who were followed up using the same serology test and pepsinogen (PG) assays on the day of endoscopy were included in the study.Results: During the follow-up of 57.7 ± 21.4 months, 61 (15.0%) of 407 seronegative subjects showed seroconversion. H. pylori infection was detected in six (9.8%) of 61 seroconverted subjects. A diffuse red fundal appearance, with a significant increase in the Kyoto classification scores for gastritis, was observed in the infected subjects (p<0.001). Compared to the false-seropositive subjects, infected subjects showed higher serology titers (p<0.001) and PG II levels (p<0.001), and lower PG I/II ratios (p=0.002), in the follow-up tests.Conclusions: Seroconversion occurred in 3.3% of seronegative subjects per year; however, only 9.8% had H. pylori infection. The majority (90.2%) of the seroconverted subjects showed false seropositivity without significant changes in the follow-up test results. The diffuse red fundal appearance could be an indicator of H. pylori infection.

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Section: Discussionmentioning

confidence: 99%

Incidence of Infection among Subjects with Helicobacter pylori Seroconversion

et al. 2022

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“…Therefore, early diagnosis or surgery is signi cantly important to the treatment of tumor. In those studies, many scholar explored the novel biomarkers for early diagnosis or evaluation the prognosis and recurrence in gastric cancer [17][18][19]. TFAP-2β constituted promoter activity in gastric cancer and contributed to the development of the metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Expression of ASPN with Prognostic Values in Gastric Cancer: A Study Based on TCGA Data

et al. 2021

Preprint

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Objective: Gastric ancer is a common cancer with high cancer-related death in the world Although, ASPN has been reported as a potential biomarker in some cancers, the relationship of ASPN and clinical pathologic features in gastric cancer has not been investigated thoroughly. Thus, the aim of study is to evaluate the function of ASPN in gastric cancer based on TCGA. Materials and methods: The gene expression data (407 cases, Workﬂow Type: HTSeq-Counts) and corresponding clinical information were downloaded from the TCGA Genomic Data Commons data portal. We performed the NES and nominal p value to evaluate the pathways enriched in each phenotype. Then, we analyzed the association with ASPN and clinicopathologic variables based on Wilcoxon signed-rank test and logistic regression. Result: We found that it was significantly different in ASPN expression between gastric cancer and normal tissue (P<0.001). High ASPN expression was signiﬁcantly associated with high stage (Odds ratio (OR)=3.656 for stage II vs stage I and OR=0.014 for stage III vs stage I), T classification (OR=13.304 for T2 vs T1, OR=20.769 for T3 vs T1 and OR=24.857 for T4 vs T1) (all p-values< 0.05). Univariate analysis revealed ASPN could result in poor overall survival with HR=1.004 and P=0.036. Besides, multivariate analysis indicated that ASPN expression was an independent risk factor for overall survival (HR:1.010, P=0.000), age (HR: 1.046, P=0.002) and gender (HR: 1.623, P=0.026). Besides, GSEA results showed that Pentose phosphate pathway, Base excision repair, Peroxisome, Protesome, Nucleotide excision repair, and Mismatch repair were differentially enriched in gastric cancer with high ASPN expression phentype. Conclusion: ASPN expression is higher in gastric cancer than normal tissues, and considered ASPN as a potential independent molecular marker for diagnosis and prognosis of GC.

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“…When atrophic change occurs, PG I level produced in chief cells decreases, as does the PG I/II ratio. In general, severe AG is determined when the PG I/II ratio is less than 3.0 [ 14 – 16 ]. Histologically, mucosal atrophy was classified according to the updated Sydney System [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

Factors influencing occurrence of metachronous gastric cancer after endoscopic resection: a systematic review and meta-analysis

Choe,

Park,

Kim

et al. 2023

Korean J Intern Med

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Background/Aims: Metachronous gastric cancer (MGC) can occur after endoscopic resection for gastric cancer. Further studies on factors other than Helicobacter pylori infection are needed. This systematic review and meta-analysis aimed to evaluate risk factors for metachronous recurrence of endoscopically resected gastric cancer.Methods: We searched medical literature published by February 2023 and identified patients with MGC after endoscopic resection for gastric cancer. The occurrence of MGC and the presence of intestinal metaplasia (IM), severe atrophic gastritis (AG), and H. pylori infection were quantitatively analyzed.Results: We identified 2,755 patients from nine cohort studies who underwent endoscopic resection for gastric cancer by 2018. Those with severe AG or presence of IM had a significantly higher incidence of MGC than those without (RR 2.00, 95% CI 1.35–2.98, I2 = 52% for severe atrophy on antrum; RR 7.08, 95% CI 3.63–13.80, I2 = 0% for antral IM). Absolute risk difference of MGC occurrence was 7.1% in those with severe AG and 9.2% in those with IM. The difference in incidence rate per 1,000 person-years was 17.5 person-years for those with severe AG and 24.7 person-years for those with IM. However, H. pylori eradication did not significantly affect the occurrence of MGC (RR 1.18, 95% CI 0.88–1.59, I2 = 10%).Conclusions: Gastric cancer patients with severe AG or presence of IM had a 2.0-fold or 7.0-fold higher risk of MGC occurrence after endoscopic resection than those without, respectively. They need more stringent follow-up to monitor MGC occurrences (CRD42023410940).

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Long‐term follow up of serum pepsinogens in patients with gastric cancer or dysplasia after Helicobacter pylori eradication

Cited by 10 publications

References 49 publications

Incidence of Infection among Subjects with Helicobacter pylori Seroconversion

Incidence of Infection among Subjects with Helicobacter pylori Seroconversion

Expression of ASPN with Prognostic Values in Gastric Cancer: A Study Based on TCGA Data

Factors influencing occurrence of metachronous gastric cancer after endoscopic resection: a systematic review and meta-analysis

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