Long-term follow-up of patients undergoing autologous noncultured melanocyte-keratinocyte transplantation for vitiligo and other leukodermas

Silpa‐archa, Narumol; Griffith, James L.; Huggins, Richard H.; Henderson, Marsha; Kerr, Holly; Jacobsen, Gordon; Mulekar, Sanjeev V.; Lim, Henry W.; Hamzavi, Iltefat

doi:10.1016/j.jaad.2017.01.056

Cited by 44 publications

(67 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both methods have yielded colour match in more than 50% of the subjects. Re‐enforcing the classical teaching of treatment refractoriness of acral areas, we noticed an inferior outcome at acral areas, even though this has been challenged in recent retrospective studies …”

Section: Discussionsupporting

confidence: 59%

“…A shorter follow‐up period of 16 weeks is a limitation in our study. Repigmentation after cellular transplantation progresses even after 16 weeks, and usually enters a plateau at 1 year . Hence, evaluation of our subjects at a longer follow‐up may yield a different result.…”

Section: Discussionmentioning

confidence: 97%

“…Autologous non‐cultured epidermal cell suspension (NCES) is a successful surgical method in vitiligo . However, the procedure needs a research laboratory with equipments like centrifuge machine and laminar flow.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Four compartment method as an efficacious and simplified technique for autologous non‐cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active‐controlled study

Mrigpuri

Kumaran²,

Vinay

et al. 2018

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Four compartment method as an efficacious and simplified technique for autologous non‐cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active‐controlled study

Mrigpuri

Kumaran²,

Vinay

et al. 2018

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…reported the relapse in 11% of the total of 177 patients and the relapse was defined by occurrence of depigmentation of previously grafted area, other sites or both. In other study that was conducted by Silpa‐Archa et al ., the active depigmentaion was reported in 21% of NSV patients while 5% of SV patients showed decreased pigmentation. van Geel et al .…”

Section: Discussionmentioning

confidence: 73%

“…To date, this is the largest study that has been conducted with the aim to search for factors associated with long‐term relapse in patients undergoing MKTP for vitiligo. Since introduction of melanocyte–keratinocyte transplantation (MTKP) in 1992, this technique has become the most popular technique used in vitiligo grafting . In fact, it is now accepted by dermatologists that in patients with stable disease, vitiligo lesions not responding to conventional treatments such as lesions located on glabrous skin, and those with leukotrichia are best suited for surgical replacement of melanocytes.…”

Section: Discussionmentioning

confidence: 99%

Six‐year follow‐up of vitiligo patients successfully treated with autologous non‐cultured melanocyte–keratinocyte transplantation

Altalhab

AlJasser

Issa³

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Although autologous non‐cultured melanocyte–keratinocyte transplantation is a treatment option for stable vitiligo, there is lack of long‐term maintenance data for this specific treatment. Objective To search for factors associated with long‐term maintenance of patients with stable vitiligo successfully treated with melanocyte–keratinocyte transplantation. Methods This was a single‐centre retrospective study including stable vitiligo patients who underwent successful melanocyte–keratinocyte transplantation in the National Center for Vitiligo, Riyadh, Saudi Arabia, between 1 January 2004 and 30 June 2015. Cox proportional hazard model was used to estimate factors associated with relapse at 6 years of followup. Co‐variates included, gender, type of vitiligo, age at vitiligo onset, age at surgical procedure, disease duration, disease stability, affected body surface area, treated surface area, fingertip involvement, type of recipient area treatment and recurrence defined as the onset of new lesions on previously untreated areas. The risk of developing relapse defined as re‐appearance of more than 10% depigmentation in a previously treated and repigmented site was considered as the main outcome. Results In total, 602 patients were included in the study of whom 410 (67%) were women. Mean age was 24.25 years [4.0–67.0]. Affected body surface area of less than 1% (adjusted HR = 0.37; P = 0.04) and mechanical dermabrasion (adjusted HR = 0.26; P = 0.03) were independently associated with lower rates of relapse. On the contrary, non‐segmental type of vitiligo (adjusted HR = 2.11; P = 0.03) and fingertip involvement (adjusted HR = 3.75; P = 0.01) were independently associated with higher rates of relapse. Conclusions Criteria for selecting patients with stable vitiligo for surgery should include careful assessment of vitiligo type including body surface area of vitiligo and involvement of fingertip before undergoing surgical procedure.

show abstract

Comparison of mechanical dermabrasion and CO₂ laser in cultured epithelial sheets transplantation in the treatment of refractory stable vitiligo: A multicenter, prospective and self‐controlled comparative study

Tang,

Luo,

et al. 2023

JEADV Clinical Practice

View full text Add to dashboard Cite

BackgroundVitiligo is an acquired depigmented disorder that causes great damage to patient's appearance and mental health. Surgical treatment plays a vital role in patients with refractory vitiligo. Recipient‐site preparation (such as liquid nitrogen, mechanical dermabrasion, chemical peeling and laser) is a key step in surgical treatment. Among them, mechanical dermabrasion and CO2 laser can achieve accurate ablation in different parts and depths.ObjectivesTo compare the advantages and disadvantages of mechanical dermabrasion and CO2 laser and their preference for different parts in cultured epithelial sheets transplantation for the treatment of vitiligo.MethodsWe used a self‐controlled study to compare the efficacy of mechanical dermabrasion and CO2 laser in 120 stable vitiligo patients of different parts at different time points after cultured epithelial sheets transplantation.ResultsNo overall difference between the mechanical dermabrasion group and the CO2 laser group. While the recovery rate of different parts of the mechanical dermabrasion group was significantly different (p < 0.05). Two methods have distinct efficacy for different parts, and CO2 laser is better at treating uneven parts.ConclusionsBoth mechanical dermabrasion and CO2 laser have good results in cultured epithelial sheets transplantation for the treatment of vitiligo.

show abstract

Long-term follow-up of patients undergoing autologous noncultured melanocyte-keratinocyte transplantation for vitiligo and other leukodermas

Cited by 44 publications

References 23 publications

Four compartment method as an efficacious and simplified technique for autologous non‐cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active‐controlled study

Four compartment method as an efficacious and simplified technique for autologous non‐cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active‐controlled study

Six‐year follow‐up of vitiligo patients successfully treated with autologous non‐cultured melanocyte–keratinocyte transplantation

Comparison of mechanical dermabrasion and CO₂ laser in cultured epithelial sheets transplantation in the treatment of refractory stable vitiligo: A multicenter, prospective and self‐controlled comparative study

Contact Info

Product

Resources

About

Long-term follow-up of patients undergoing autologous noncultured melanocyte-keratinocyte transplantation for vitiligo and other leukodermas

Cited by 44 publications

References 23 publications

Four compartment method as an efficacious and simplified technique for autologous non‐cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active‐controlled study

Four compartment method as an efficacious and simplified technique for autologous non‐cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active‐controlled study

Six‐year follow‐up of vitiligo patients successfully treated with autologous non‐cultured melanocyte–keratinocyte transplantation

Comparison of mechanical dermabrasion and CO2 laser in cultured epithelial sheets transplantation in the treatment of refractory stable vitiligo: A multicenter, prospective and self‐controlled comparative study

Contact Info

Product

Resources

About

Comparison of mechanical dermabrasion and CO₂ laser in cultured epithelial sheets transplantation in the treatment of refractory stable vitiligo: A multicenter, prospective and self‐controlled comparative study