Long-term follow-up of coronary artery disease presenting in young adults

Cole, Jason; Miller, Joseph I.; Sperling, Laurence; Weintraub, William S.

doi:10.1016/s0735-1097(02)02862-0

Cited by 215 publications

(233 citation statements)

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“…Angiographic characteristics were compared between male and female patients. SVD, DVD and TVD were present in 41%, 44.5%, and 14.5% of males and 60%, 22.5% and 17.5% of females respectively .Where as Jason H. et al (16) reported SVD,DVD and TVD in 55%, 27%,15% of young males and 60%,24.5% and 12.8% of young female patients respectively. Complications following PCI occurred at a low frequency.…”

Section: Discussionmentioning

confidence: 94%

Comparison of Clinical profile and outcome between young (≤45yrs) male and female patients with coronary artery disease undergoing percutaneous coronary intervention, a single center study

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2017

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Section: Discussionmentioning

confidence: 94%

Comparison of Clinical profile and outcome between young (≤45yrs) male and female patients with coronary artery disease undergoing percutaneous coronary intervention, a single center study

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2017

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“…Although previous studies have put forward data on coronary risk factors (6-9), long-term outcome of MI survivors (12,13), and extent of angiographic coronary lesions (9)(10)(11)14), we believe that the available data was not sufficient to provide adequate information about angiographic profile based on the type of acute coronary syndrome. In this regard, the present study provides valuable insights regarding the similarities and differences in coronary risk factors and angiographic characteristics in STEMI and NSTEMI/UA patients.…”

Section: Discussionmentioning

confidence: 99%

Demographic and angiographic profile in premature cases of acute coronary syndrome: analysis of 820 young patients from South India

Deora

Kumar

Ramalingam³

et al. 2016

Cardiovasc. Diagn. Ther.

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Background: Prevalence of acute coronary syndrome in young individuals is increasing progressively.Previous studies have focused on the analysis of risk factors and to some extent coronary angiographic profile in young vs. old patients with acute coronary syndrome, but no study compared the angiographic profile in young patients based on the type of acute coronary syndrome. So, this study was conducted to determine the differences in demographic and coronary angiographic profile of young patients with ST-elevated myocardial infarction (STEMI) vs. those with non-ST-elevated myocardial infarction (NSTEMI) or unstable angina (UA).Methods: We retrospectively analyzed young patients (age <40 years) with acute coronary syndrome who underwent coronary angiography at Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, India between April 2010 and March 2011. Coronary risk factor profile and angiographic features were compared between STEMI and NSTEMI/UA patients.Results: Of 8,268 patients who underwent coronary angiography during the study period, 820 (~10%) were ≤40 year age. Of them, 611 exhibited STEMI and 209 exhibited NSTEMI/UA. Angiographic analysis revealed that single-vessel disease was significantly more common in the STEMI group (56.6% vs. 36.6% respectively; P<0.001) whereas triple-vessel disease was significantly more common in the NSTEMI/UA group (3.6% vs. 10.5% respectively; P<0.001). Conversely, left anterior descending coronary artery was more commonly involved in the STEMI group (55.3% vs. 40.2% respectively; P<0.001), whereas left circumflex coronary artery was more commonly involved in the NSTEMI/UA group (11.8 vs. 23.4% respectively; P<0.001). Of note, smoking/tobacco consumption was the most significant coronary risk factor with prevalence as high as 65% in both groups.Conclusions: In the present study, significant differences were observed in coronary risk factor profile and angiographic features between young patients with STEMI and NSTEMI/UA. Larger studies will be required to establish specific associations between presentation of acute coronary syndromes and angiographic profiles in young patients.

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“…It was shown in the PDAY study [16] and the Bogalusa Heart Study [17] that atherogenesis begins already in childhood, and the extent of lipid-rich plaques depends on such factors as age, non-high density lipoprotein cholesterol (HDL-C) level, hypertension, hyperglycaemia, obesity, and tobacco smoking. Prospective cohort studies including the Muscatine Study [18] and the Cardiovascular Risk in Young Finns Study [19] showed relations between coronary risk factors evaluated in childhood or early adulthood and the coronary calcium score or the carotid artery intima-media thickness, both surrogate markers of atherosclerosis during later life.…”

Section: Discussionmentioning

confidence: 99%

Clinical and angiographic characteristics of coronary artery disease in young adults: a single centre study

Maroszyńska-Dmoch

Wożakowska−Kapłon

2016

Kardiol Pol

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A b s t r a c tBackground: Coronary artery disease (CAD) in young adults under 40 years of age is a growing medical, social, psychological and economical problem, related to the prevalence of civilization-related diseases and unhealthy lifestyle. The problem of CAD in young people has not been characterised as well as in older individuals, as the available data mostly come from case reports and small series, often related to genetic aspects and familial occurrence of the disease. Aim:To assess clinical and angiographic characteristics of young adults with CAD and to evaluate in-hospital and long-term mortality in this patient group. The study combined a retrospective and a prospective approach.Methods: A total of 239 patients aged 40 years or younger who underwent coronary angiography (CAG) in the Swietokrzyskie Centre of Cardiology in Kielce in [2001][2002][2003][2004][2005][2006][2007][2008] were included in this study. Demographic characteristics, risk factor profile, laboratory test results, electrocardiographic and echocardiographic findings, CAG findings, and in-hospital mortality were assessed retrospectively in the selected groups. During the second stage of the study, clinical and mortality data were obtained prospectively in 130 patients (54.4% of the study group) during up to 5 years of follow-up. Results:The mean patient age was 35.1 ± 4.4 years. Men made up 86.2% of the study sample, and the proportion of rural area residents was 54.8%. Among young patients with acute coronary syndromes (ACS), the most common presentation (52.8%) was ST segment elevation myocardial infarction (STEMI). Angiographically normal coronary arteries were found in 37.2% of CAD patients and in 16.9% of patients with the diagnosis of ACS. The mean degree of coronary artery lumen stenosis was 75.4% in the group with significant atherosclerotic coronary lesions (50-90%) and 95.9% in the group demonstrating a critical coronary obstruction (≥ 90%). Single-vessel disease was identified in 61.9% of patients with a positive result of CAG (stenosis > 50%, CORO(+) group). The most common location of significant atherosclerotic coronary lesions was the left anterior descending artery (61.6%) followed by the right coronary artery (27.4%). The most prevalent conventional cardiovascular risk factors were lipid abnormalities, cigarette smoking and an increased body mass index ≥ 25 kg/m 2 , followed by a family history of CAD and hypertension. The proportion of patients with abnormal lipid profile, cigarette smoking and overweight or obesity was particularly high in the CORO(+) group (85.6%, 83.9%, and 64.4%, respectively). In-hospital mortality rate was low, at 0.7% among ACS patients. Long-term mortality during up to 5 years of follow-up was not so favourable, at 7.75% in ACS patients and 8.5% in the CORO(+) group. Conclusions:The population of young patients with CAD is predominantly male, rural, and characterised by a low socioeconomic status. The aetiology of CAD in this patient group differs significantly from that in older patients a...

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Long-term follow-up of coronary artery disease presenting in young adults

Abstract: Coronary disease in young adults can carry a poor long-term prognosis. A prior MI, diabetes, active tobacco abuse, and lower EF predict a significantly higher mortality.

Cited by 215 publications

References 34 publications

Comparison of Clinical profile and outcome between young (≤45yrs) male and female patients with coronary artery disease undergoing percutaneous coronary intervention, a single center study

Comparison of Clinical profile and outcome between young (≤45yrs) male and female patients with coronary artery disease undergoing percutaneous coronary intervention, a single center study

Demographic and angiographic profile in premature cases of acute coronary syndrome: analysis of 820 young patients from South India

Clinical and angiographic characteristics of coronary artery disease in young adults: a single centre study

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