Long-Term Exposure to Silica Dust and Risk of Total and Cause-Specific Mortality in Chinese Workers: A Cohort Study

Chen, Weihong; Liu, Yue-Wei; Wang, Haijiao; Hnizdo, Eva; Sun, Yi; Su, Lili; Zhang, Xiaokang; Weng, Shaofan; Frank, Benedikt; Hearl, Frank J.; Chen, Jingqiong; Wu, Tangchun

doi:10.1371/journal.pmed.1001206

Cited by 224 publications

(171 citation statements)

References 32 publications

(28 reference statements)

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“…All the concentrations were assessed monthly based on a gravimetric method and were reported in the form of average level per year. Cumulative exposure to dust (mg/m 3 -years) was calculated for each participant by multiplying the intensity of dust exposure by the duration of work (Chen et al 2012). Spirometry tests were performed by trained technicians using a portable spirometer (Chestgraph, HI-101, CHEST MI Inc., Tokyo, Japan) according to the criteria of the American Thoracic Society (Miller et al 2005).…”

Section: Study Subjectsmentioning

confidence: 99%

COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study

Cui

Xing

Liu

et al. 2015

Cell Stress and Chaperones

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This case-control study aimed to investigate whether the levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes were associated with the risk of chronic obstructive pulmonary disease (COPD) among coal workers. A total of 76 COPD cases and 48 age-matched healthy controls from a group of coal workers were included. The case group consisted of 35 COPD patients whose condition was complicated with coal workers' pneumoconiosis (CWP) and 41 COPD patients without CWP. Heat shock proteins (Hsps) in plasma and lymphocytes were detected by ELISA and flow cytometry, respectively. Multiple logistic regression models were applied to estimate the association between Hsp levels and COPD risk. Our results showed that plasma Hsp70 and lymphocyte Hsp27 levels were significantly higher and plasma Hsp27 levels were significantly lower in COPD cases than in controls (p<0.01). No significant differences in lymphocyte Hsp70 levels were found between COPD cases and the matched subjects. Higher plasma Hsp70 levels (odds ratio (OR)=13.8, 95 % confidence interval (CI)=5.7-33.5) and lower plasma Hsp27 levels (OR=4.6, 95 % CI= 2.0-10.5) were significantly associated with an increased risk of COPD after adjusting for confounders. Higher lymphocyte Hsp27 levels were only associated with an increased risk of COPD with CWP (OR=6.6, 95 % CI=2.0-22.1) but not with an increased risk of COPD without CWP (OR=3.0, 95 % CI= 0.9-8.9). Additionally, there were strong joint effects of different Hsps on COPD risk. These results showed that higher levels of plasma Hsp70 and lower levels of plasma Hsp27 might be associated with an increased risk of COPD among coal workers. They may have the potential to serve as monitoring markers for COPD in coal workers.

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Section: Study Subjectsmentioning

confidence: 99%

COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study

Cui

Xing

Liu

et al. 2015

Cell Stress and Chaperones

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“…In 1997, the International Agency for Research on Cancer (IARC) announced crystalline silica is carcinogenic to humans (group 1) (2). Silica dust can also increase the mortality rate from respiratory diseases and cardiovascular diseases (3). Exposure to silica can cause abnormal gene expression (4).…”

Section: Introductionmentioning

confidence: 99%

Global DNA methylation and PTEN hypermethylation alterations in lung tissues from human silicosis

et al. 2016

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Background: Silicosis is a respiratory disease caused by long-term silica dust exposure. Our previous study has demonstrated that silica mediates the activation of phosphatidylinositol 3-kinase (PI3K)/phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/serine or threonine kinase (AKT)/mitogen-activated protein kinases (MAPK)/AP-1 pathway in human embryo lung fibroblasts (HELFs). The purpose of this study is to identify genome-wide aberrant DNA methylation profiling in lung tissues from silicosis patients. Conclusions: Abnormal DNA methylation on genome-scale was implicated in silicosis, and PTEN promoter hypermethylation might be associated with decrease of PTEN protein.

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“…Pneumoconiosis is still one of the most serious occupational disease over the world, especially in developing countries (Naidoo et al, 2005;Chen et al, 2012;Oyunbileg et al, 2011;Pingle et al, 2012). By the end of 2012, the total of pneumoconiosis patients is 727148 in china, which is 76.74% of the total number of occupational disease.…”

Section: Introductionmentioning

confidence: 99%

Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People

Chen

Fan²,

Jin³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Long-Term Exposure to Silica Dust and Risk of Total and Cause-Specific Mortality in Chinese Workers: A Cohort Study

Abstract: A retro-prospective cohort study by Weihong Chen and colleagues provides new estimates for the risk of total and cause-specific mortality due to long-term silica dust exposure among Chinese workers.

Cited by 224 publications

References 32 publications

COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study

COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study

Global DNA methylation and PTEN hypermethylation alterations in lung tissues from human silicosis

Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People

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