Long-term exposure to low 17α-ethinylestradiol (EE2) concentrations disrupts both the reproductive and the immune system of juvenile rainbow trout, Oncorhynchus mykiss

Rehberger, Kristina; Siebenthal, Elena Wernicke von; Bailey, Christyn; Bregy, Patrick; Fasel, Melanie; Herzog, Elio L.; Neumann, Silvia; Schmidt‐Posthaus, Heike; Segner, Helmut

doi:10.1016/j.envint.2020.105836

Cited by 28 publications

(23 citation statements)

References 121 publications

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“…In more recent studies, hepatic vtg mRNA expression was significantly enhanced in Atlantic salmon (Salmo salar) fries following waterborne exposure to 0.04 nM 17α-ethinylestradiol (EE2) and 40 nM 4-nonylphenol (NP) for 21 days (Breves et al, 2018) and in juvenile rainbow trout (O. mykiss) exposed to 5.5 ng/L EE2 for 14 days (Rehberger et al, 2020). In line with that, exposure of goldfish (C.…”

Section: Xenos Teroids Effec Ts On Reproduc Tive Dys Fun C Tionmentioning

confidence: 54%

“…Additionally, altered immune responses were reported in the same fish species exposed to 5.5 ng/L EE 2 for 108 days in correlation with significantly increased transcription of ERα2 and G proteincoupled oestrogen receptor (GPER) in the head kidney (Rehberger et al, 2020). Moreover, immune responses of common carp were found to be modulated following in vivo exposure to EE2 in correlation with altered expression of nuclear (erα and erβ) and membrane oestrogen receptors (gpr30) in peritoneal leukocytes and the liver (Maciuszek et al, 2020).…”

Section: Xenos Teroids Effec Ts On Immune Re Sp Onse Smentioning

confidence: 95%

“…and interferonγ (infγ) mRNA at an exposure level of 1000 µg/L and significantly increased expression of interleukin 10 (il-10) and heat shock protein 70 (hsp-70) mRNA at exposure level 10 μg/L and 100 or 1000 μg/l respectively (Faheem et al, 2020). Additionally, an acute-phase protein, hepcidin transcription, was significantly decreased in juvenile rainbow trout (O. mykiss) exposed to 5.5ng/L EE 2 for 108 days (Rehberger et al, 2020). In line with that, dietary administration of EE2 and Tmx modulated the innate immune response of gilthead seabream by inhibiting the cytokines il1b and il-10 gene expression in seabream, decreased the reactive oxygen species (ROS) production, and increased the specific IgM after vaccination of naïve fish (Rodenas et al, 2015(Rodenas et al, , 2016.…”

Section: Xenos Teroids Effec Ts On Immune Re Sp Onse Smentioning

confidence: 99%

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Xenosteroids in aquaculture with special consideration to Lake Manzala (Northern delta lake, Egypt): Types, sources and mechanism of action

et al. 2021

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Egyptian aquaculture production has dramatically increased in recent years and is anticipated to represent a yield of 1.8MMT in 2018. Increased demand for fish production has led to a higher intensification of aquaculture to face these challenges.However, the current aquaculture practices and restricted governmental legislation can prompt raised concerns about aquaculture pollution. The current review summarizes our knowledge concerning general Egyptian aquaculture, legislation and practices that can lead to persistent pollutant exposure in farmed finfish. Xenosteroids are critical pollutants influencing fish health, as detailed in this review, and are considered significant health hazards not only to cultured fish but also to human wellbeing, raising a public health concern. Additional research studies are warranted to better understand their public health concerns and develop strategic plans and policies to prevent these impacts and maintain fish welfare and aquaculture sustainability.

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Section: Xenos Teroids Effec Ts On Reproduc Tive Dys Fun C Tionmentioning

confidence: 54%

Section: Xenos Teroids Effec Ts On Immune Re Sp Onse Smentioning

confidence: 95%

Section: Xenos Teroids Effec Ts On Immune Re Sp Onse Smentioning

confidence: 99%

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Xenosteroids in aquaculture with special consideration to Lake Manzala (Northern delta lake, Egypt): Types, sources and mechanism of action

et al. 2021

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“…The experimental findings of Bera et al, 71 established that triclosan suppressed both cell-mediated and humoral immune responses with a decrease in respiratory burst activity (RBA), myeloperoxidase activity (MPO), phagocytic activity (PA) in triclosan exposed catfish, Pangasianodon hypophthalmus). In an experiment, Rehberger et al, 72 demonstrated that the chronic exposure to low ethinylestradiol (EE2) concentrations combined with parasite infection in juvenile rainbow trout (Oncorhynchus mykiss) can induce endocrine disruptive and immunomodulating activities.…”

Section: Impacts Of Residual Pharmaceuticals On Fishmentioning

confidence: 99%

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2021

IJPSR

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“…Therefore, oestrogen-exposure during thymus ontogenesis may have long-term consequences for the T cell-dependent immune response in mammals (Chapman et al, 2009;Forsberg, 2000) and in fish (Rehberger et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The influence of 17β-oestradiol on lymphopoiesis and immune system ontogenesis in juvenile sea bass, Dicentrarchus labrax

Moreira

Paiola

Duflot

et al. 2021

Developmental & Comparative Immunology

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The female sex steroid 17β-oestradiol (E2) is involved in the regulation of numerous physiological functions, including the immune system development and performance. The role of oestrogens during ontogenesis is, however, not well studied. In rodents and fish, thymus maturation appears to be oestrogen-dependent. Nevertheless, little is known about the function of oestrogen in immune system development. To further the understanding of the role of oestrogens in fish immune system ontogenesis, fingerlings of European sea bass (Dicentrarchus labrax) were exposed for 30 days to 20 ng E2 •L -1 , at two ages tightly related to thymic maturation, i.e., 60 or 90 days post hatch (dph). The expression of nuclear and membrane oestrogen receptors was measured in the thymus and spleen, and the expression of several T cell-related gene markers was studied in both immune organs, as well as in the liver. Waterborne E2-exposure at 20.2 ± 2.1 (S.E.) ng•L -1 was confirmed by radioimmunoassay, leading to significantly higher E2-contents in the liver of exposed fish. The majority of gene markers presented age-dependent dynamics in at least one of the organs, confirming thymus maturation, but also suggesting a critical ontogenetic window for the implementation of liver resident γδ and αβ T cells. The oestrogen receptors, however, remained unchanged over the age and treatment comparisons with the exception of esr2b, which was modulated by E2 in the younger cohort and increased its expression with age in the thymus of the older cohort, as did the membrane oestrogen receptor gpera.These results confirm that oestrogen-signalling is involved in thymus maturation in European sea bass, as it is in mammals. This suggests that esr2b and gpera play key roles during thymus ontogenesis, particularly during medulla maturation. In contrasts, the spleen expressed low or non-detectable levels of oestrogen receptors. The E2-exposure decreased the expression of tcrγ in the liver in the cohort exposed from 93 to 122 dph, but not the expression of any other immune-related gene analysed. These results indicate that the proliferation/migration of these innate-like T cell populations is oestrogensensitive. In regards to the apparent prominent role of oestrogen-signalling in the late thymus maturation stage, the thymic differentiation of the corresponding subpopulations of T cells might be regulated by oestrogen. To the best of our knowledge, this is the first study investigating the dynamics of both nuclear and membrane oestrogen receptors in specific immune organs in a teleost fish at very early stages of immune system development as well as to examine thymic function in sea bass after an exposure to E2 during ontogenesis.

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Long-term exposure to low 17α-ethinylestradiol (EE2) concentrations disrupts both the reproductive and the immune system of juvenile rainbow trout, Oncorhynchus mykiss

Cited by 28 publications

References 121 publications

Xenosteroids in aquaculture with special consideration to Lake Manzala (Northern delta lake, Egypt): Types, sources and mechanism of action

Xenosteroids in aquaculture with special consideration to Lake Manzala (Northern delta lake, Egypt): Types, sources and mechanism of action

Untitled

The influence of 17β-oestradiol on lymphopoiesis and immune system ontogenesis in juvenile sea bass, Dicentrarchus labrax

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