Long-Term Exposure to Ceftriaxone Sodium Induces Alteration of Gut Microbiota Accompanied by Abnormal Behaviors in Mice

Zhao, Zhongyi; Wang, Baoning; Mu, Liyuan; Wang, Hongren; Luo, Jingjing; Yuan, Yuan; Yang, Hui‐Fang; Li, Mingyuan; Zhou, Lingsha; Tao, Chuanmin

doi:10.3389/fcimb.2020.00258

Cited by 33 publications

(16 citation statements)

References 104 publications

(129 reference statements)

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“…It should be noted that the overall post-surgery condition included ceftriaxone treatment of all patients. This beta-lactam antibiotic is able to kill a broad spectrum of bacteria [ 45 ], thus potentially shaping the gut bacteriobiome [ 46 ], especially when administered orally. Therefore, despite the very short time between the surgery and stool collection in this study, and hence the short time of antibiotic treatment, the revealed changes in the fecal bacteriobiome might have resulted, in part, due to the antibiotic per se.…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiome in a Russian Cohort of Pre- and Post-Cholecystectomy Female Patients

Григорьева

Romanova

Naumova

et al. 2021

JPM

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The last decade saw extensive studies of the human gut microbiome and its relationship to specific diseases, including gallstone disease (GSD). The information about the gut microbiome in GSD-afflicted Russian patients is scarce, despite the increasing GSD incidence worldwide. Although the gut microbiota was described in some GSD cohorts, little is known regarding the gut microbiome before and after cholecystectomy (CCE). By using Illumina MiSeq sequencing of 16S rRNA gene amplicons, we inventoried the fecal bacteriobiome composition and structure in GSD-afflicted females, seeking to reveal associations with age, BMI and some blood biochemistry. Overall, 11 bacterial phyla were identified, containing 916 operational taxonomic units (OTUs). The fecal bacteriobiome was dominated by Firmicutes (66% relative abundance), followed by Bacteroidetes (19%), Actinobacteria (8%) and Proteobacteria (4%) phyla. Most (97%) of the OTUs were minor or rare species with ≤1% relative abundance. Prevotella and Enterocossus were linked to blood bilirubin. Some taxa had differential pre- and post-CCE abundance, despite the very short time (1–3 days) elapsed after CCE. The detailed description of the bacteriobiome in pre-CCE female patients suggests bacterial foci for further research to elucidate the gut microbiota and GSD relationship and has potentially important biological and medical implications regarding gut bacteria involvement in the increased GSD incidence rate in females.

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Section: Discussionmentioning

confidence: 99%

Gut Microbiome in a Russian Cohort of Pre- and Post-Cholecystectomy Female Patients

Григорьева

Romanova

Naumova

et al. 2021

JPM

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“…In addition to early life being of critical importance in terms of disruptive antibiotic effect on gut microbiota, antibiotic studies on adult animals also showed impaired behavior and brain function [ 71 , 83 , 93 , 94 , 95 ] and neurodegenerative disorders [ 96 ] both in prolonged and short courses, supporting the crucial role of gut microbiota-brain axis during lifespan. Some of the studies showed that these disruptive effects can be rescued by probiotic administrations [ 89 , 97 ].…”

Section: Impact Of Antibiotic Use On Gut Microbiome-brain Axismentioning

confidence: 99%

Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders

et al. 2021

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Gut microbiota composition and function are major areas of research for functional gastrointestinal disorders. There is a connection between gastrointestinal tract and central nervous system and this is mediated by neurotransmitters, inflammatory cytokines, the vagus nerve and the hypothalamic-pituitary-adrenal axis. Functional gastrointestinal disorders are prevalent diseases affecting more than one third of the population. The etiology of these disorders is not clarified. Visceral hyperalgesia is the main hypothesis for explaining clinical symptoms, however gut-brain axis disorder is a new terminology for functional disorders. In this review, microbiota-gut-brain axis connection pathways and related disorders are discussed. Antibiotics are widely used in developed countries and recent evidence indicates antibiotic-induced dysbiosis as an important factor for functional disorders. Antibiotics exert negative effects on gut microbiota composition and functions. Antibiotic-induced dysbiosis is a major factor for occurrence of post-infectious irritable bowel syndrome. Cognitive and mood disorders are also frequent in functional gastrointestinal disorders. Animal and human trials show strong evidence for the causal relationship between gut microbiota and brain functions. Therapeutic implications of these newly defined pathogenic pathways are also discussed.

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“…In contrast to this evidence, male F344 rats housed in germ-free conditions exhibited increased anxiety-like behaviour in the open field test 19 . Furthermore, adolescent antibiotic treatment was shown to considerably increase anxiety-like behaviour in adult male C57Bl/6OlaHsd mice, whereas no significant changes in adult anxiety-like behaviour were observed following adult antibiotic treatment in male C57Bl/6OlaHsd or BALB/c mice 20 , 21 . When we used this antibiotic treatment protocol in female C57BL/6 mice in another study, we found that gut microbiota depletion increased anxiety-like behaviour in mice with or without experimental autoimmune encephalomyelitis (EAE) 5 .…”

Section: Discussionmentioning

confidence: 88%

“…Alterations in the diversity and composition of gut microbial ecosystems are associated with anxiety-related disorders and major depression. Substantial research has demonstrated that rodents treated with antibiotics or bred under germ-free conditions display significant changes in anxiety- and depression-related behaviours 1 , 5 , 8 , 16 – 21 . Furthermore, clinical studies suggest considerable comorbidity between AD and anxiety or depression 22 , 23 .…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease

Mosaferi

Jand

Salari

2021

Sci Rep

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The gut-microbiota–brain axis plays an important role in stress-related disorders, and dysfunction of this complex bidirectional system is associated with Alzheimer’s disease. This study aimed to assess the idea that whether gut microbiota depletion from early adolescence can alter anxiety- and depression-related behaviours in adult mice with or without Alzheimer-like disease. Male C57BL/6 mice were treated with an antibiotic cocktail from weaning to adulthood. Adult mice received an intracerebroventricular injection of amyloid-beta (Aβ)1–42, and were subjected to anxiety and depression tests. We measured, brain malondialdehyde and glutathione following anxiety tests, and assessed brain oxytocin and the hypothalamic–pituitary–adrenal (HPA) axis function by measuring adrenocorticotrophic hormone (ACTH) and corticosterone following depression tests. Healthy antibiotic-treated mice displayed significant decreases in anxiety-like behaviours, whereas they did not show any alterations in depression-like behaviours and HPA axis function. Antibiotic treatment from early adolescence prevented the development of anxiety- and depression-related behaviours, oxidative stress and HPA axis dysregulation in Alzheimer-induced mice. Antibiotic treatment increased oxytocin in the brain of healthy but not Alzheimer-induced mice. Taken together, these findings suggest that gut microbiota depletion following antibiotic treatment from early adolescence might profoundly affect anxiety- and depression-related behaviours, and HPA axis function in adult mice with Alzheimer-like disease.

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Long-Term Exposure to Ceftriaxone Sodium Induces Alteration of Gut Microbiota Accompanied by Abnormal Behaviors in Mice

Cited by 33 publications

References 104 publications

Gut Microbiome in a Russian Cohort of Pre- and Post-Cholecystectomy Female Patients

Gut Microbiome in a Russian Cohort of Pre- and Post-Cholecystectomy Female Patients

Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders

Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease

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