Long-term exposure to ambient air pollution and risk of dementia: Results of the prospective Three-City Study

Mortamais, Marion; Gutierrez, Laure‐Anne; Hoogh, Kees de; Chen, Jie; Vienneau, Danielle; Carrière, Isabelle; Letellier, Noémie; Helmer, Catherine; Gabelle, Audrey; Mura, Thibault; Sunyer, Jordi; Benmarhnia, Tarik; Jacquemin, Bénédicte; Berr, Claudine

doi:10.1016/j.envint.2020.106376

Cited by 71 publications

(47 citation statements)

References 24 publications

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“…Recent evidence from around the world has identified a significant role for air pollution in the pathophysiology of dementia [ 1 , 2 , 3 , 4 , 5 ]. In our earlier research, neuropathological hallmarks of Alzheimer’s disease (AD), Parkinson’s disease (PD) and transactive response DNA-binding protein TDP-43 pathology in young megacity residents have been documented at post-mortem, even in toddlers [ 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

Calderón‐Garcidueñas

Rajkumar

Stommel

et al. 2021

IJERPH

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Quadruple aberrant hyperphosphorylated tau (p-τ), amyloid-β peptide, alpha-synuclein and TDP-43 brainstem and supratentorial pathology are documented in forensic ≤40y autopsies in Metropolitan Mexico City (MMC), and p-τ is the major aberrant protein. Post-traumatic stress disorder (PTSD) is associated with an elevated risk of subsequent dementia, and rapid eye movement sleep behavior disorder (RBD) is documented in PD, AD, Lewy body dementia and ALS. This study aimed to identify an association between PTSD and potential pRBD in Mexico. An anonymous online survey of 4502 urban college-educated adults, 29.3 ± 10.3 years; MMC, n = 1865; non-MMC, n = 2637, measured PTSD symptoms using the Impact of Event Scale–Revised (IES-R) and pRBD symptoms using the RBD Single-Question. Over 50% of the participants had IES-R scores ≥33 indicating probable PTSD. pRBD was identified in 22.6% of the participants across Mexico and 32.7% in MMC residents with PTSD. MMC subjects with PTSD had an OR 2.6218 [2.5348, 2.7117] of answering yes to the pRBD. PTSD and pRBD were more common in women. This study showed an association between PTSD and pRBD, strengthening the possibility of a connection with misfolded proteinopathies in young urbanites. We need to confirm the RBD diagnosis using an overnight polysomnogram. Mexican women are at high risk for stress and sleep disorders.

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Section: Introductionmentioning

confidence: 99%

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

Calderón‐Garcidueñas

Rajkumar

Stommel

et al. 2021

IJERPH

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“…Fu and Yung 5 published a review and meta-analysis of AD and air pollution, and found a twofold excess risk of AD for a 10 µg/m 3 increase of PM 2.5 among six studies, and no increased risk for NO 2 in four studies, nor for O 3 in three studies. There have been several longitudinal studies since these reviews, with the majority finding positive associations between air pollutants and either dementia or AD [6][7][8][9][10][11][12][13][14] . A few of these studies examine the associations in US populations, and these studies have almost exclusively used hospitalization as a measure of morbidity 6,7,11,13 .…”

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confidence: 99%

A national cohort study (2000–2018) of long-term air pollution exposure and incident dementia in older adults in the United States

et al. 2021

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Air pollution may increase risk of Alzheimer’s disease and related dementias (ADRD) in the U.S., but the extent of this relationship is unclear. Here, we constructed two national U.S. population-based cohorts of those aged ≥65 from the Medicare Chronic Conditions Warehouse (2000–2018), combined with high-resolution air pollution datasets, to investigate the association of long-term exposure to ambient fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) with dementia and AD incidence, respectively. We identified ~2.0 million incident dementia cases (N = 12,233,371; dementia cohort) and ~0.8 million incident AD cases (N = 12,456,447; AD cohort). Per interquartile range (IQR) increase in the 5-year average PM2.5 (3.2 µg/m3), NO2 (11.6 ppb), and warm-season O3 (5.3 ppb) over the past 5 years prior to diagnosis, the hazard ratios (HRs) were 1.060 (95% confidence interval [CI]: 1.054, 1.066), 1.019 (95% CI: 1.012, 1.026), and 0.990 (95% CI: 0.987, 0.993) for incident dementias, and 1.078 (95% CI: 1.070, 1.086), 1.031 (95% CI: 1.023, 1.039), and 0.982 (95%CI: 0.977, 0.986) for incident AD, respectively, for the three pollutants. For both outcomes, concentration-response relationships for PM2.5 and NO2 were approximately linear. Our study suggests that exposures to PM2.5 and NO2 are associated with incidence of dementia and AD.

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“…Previous studies have documented that the continuing increase in PM 2.5 poses various health threats, such as premature mortality and excess morbidity, which provide significant information for measuring the harmful effects of ambient air pollution (S. Chen et al., 2020; S. Liu et al., 2020; Lubczyńska et al., 2017; Mortamais et al., 2021; Xue et al., 2019; Yang et al., 2020). The scientific assessment of PM 2.5 exposure risk is the foundation for these investigations.…”

Section: Discussionmentioning

confidence: 99%

Mapping Total Exceedance PM_2.5 Exposure Risk by Coupling Social Media Data and Population Modeling Data

Cao

Guo

et al. 2021

GeoHealth

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The PM2.5 exposure risk assessment is the foundation to reduce its adverse effects. Population survey‐related data have been deficient in high spatiotemporal detailed descriptions. Social media data can quantify the PM2.5 exposure risk at high spatiotemporal resolutions. However, due to the no‐sample characteristics of social media data, PM2.5 exposure risk for older adults is absent. We proposed combining social media data and population survey‐derived data to map the total PM2.5 exposure risk. Hourly exceedance PM2.5 exposure risk indicators based on population modeling (HEPEpmd) and social media data (HEPEsm) were developed. Daily accumulative HEPEsm and HEPEpsd ranged from 0 to 0.009 and 0 to 0.026, respectively. Three peaks of HEPEsm and HEPEpsd were observed at 13:00, 18:00, and 22:00. The peak value of HEPEsm increased with time, which exhibited a reverse trend to HEPEpsd. The spatial center of HEPEsm moved from the northwest of the study area to the center. The spatial center of HEPEpsd moved from the northwest of the study area to the southwest of the study area. The expansion area of HEPEsm was nearly 1.5 times larger than that of HEPEpsd. The expansion areas of HEPEpsd aggregated in the old downtown, in which the contribution of HEPEpsd was greater than 90%. Thus, this study introduced various source data to build an easier and reliable method to map total exceedance PM2.5 exposure risk. Consequently, exposure risk results provided foundations to develop PM2.5 pollution mitigation strategies as well as scientific supports for sustainability and eco‐health achievement.

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Long-term exposure to ambient air pollution and risk of dementia: Results of the prospective Three-City Study

Cited by 71 publications

References 24 publications

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

A national cohort study (2000–2018) of long-term air pollution exposure and incident dementia in older adults in the United States

Mapping Total Exceedance PM_2.5 Exposure Risk by Coupling Social Media Data and Population Modeling Data

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Long-term exposure to ambient air pollution and risk of dementia: Results of the prospective Three-City Study

Cited by 71 publications

References 24 publications

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

A national cohort study (2000–2018) of long-term air pollution exposure and incident dementia in older adults in the United States

Mapping Total Exceedance PM2.5 Exposure Risk by Coupling Social Media Data and Population Modeling Data

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Product

Resources

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Mapping Total Exceedance PM_2.5 Exposure Risk by Coupling Social Media Data and Population Modeling Data