Long-term exposure to 2-amino-3-methylimidazo[4,5-f]quinoline can trigger a potential risk of Parkinson's disease

Li, Zhi; Cao, Peipei; Meng, Huiling; Li, Dan; Zhang, Yan; Li, Yuhao; Wang, Shuo

doi:10.1016/j.jhazmat.2021.125230

Cited by 18 publications

(14 citation statements)

References 79 publications

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“…The harmful dose of HCA has been reported mainly for in vitro and animal models, this due to the ethical restrictions of human studies and depend on the specific HCA. Recently, concentrations of 8 to 800 ng/mL of 2-Amino-3-methylimidazole [4,5-f] quinoline (one of the most common HCA) have been associated with damage to hepatocytes and induction of Parkinson's disease gen protein using zebrafish ( Danio rerio ) ( Li et al, 2021 , Li et al, 2021 ).…”

Section: Microbial Metabolites From Undigested Protein Colonic Fermen...mentioning

confidence: 99%

What we know about protein gut metabolites: Implications and insights for human health and diseases

et al. 2022

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Section: Microbial Metabolites From Undigested Protein Colonic Fermen...mentioning

confidence: 99%

What we know about protein gut metabolites: Implications and insights for human health and diseases

et al. 2022

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“…Coincidentally, zinc oxide nanomaterials disrupt locomotor activity and induce apoptosis and neuronal loss in zebrafish (Jin et al, 2021). More recently, other researchers have also suggested that long-term exposure to a heterocyclic amine from a wide range of pollutants, contributes to the potential risk of PD (Li et al, 2021).…”

Section: Neurotoxic Zebrafish Models Of Parkinson's Diseasementioning

confidence: 99%

Advances of Zebrafish in Neurodegenerative Disease: From Models to Drug Discovery

Wang

Zhang

et al. 2021

Front. Pharmacol.

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Neurodegenerative disease (NDD), including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, are characterized by the progressive loss of neurons which leads to the decline of motor and/or cognitive function. Currently, the prevalence of NDD is rapidly increasing in the aging population. However, valid drugs or treatment for NDD are still lacking. The clinical heterogeneity and complex pathogenesis of NDD pose a great challenge for the development of disease-modifying therapies. Numerous animal models have been generated to mimic the pathological conditions of these diseases for drug discovery. Among them, zebrafish (Danio rerio) models are progressively emerging and becoming a powerful tool for in vivo study of NDD. Extensive use of zebrafish in pharmacology research or drug screening is due to the high conserved evolution and 87% homology to humans. In this review, we summarize the zebrafish models used in NDD studies, and highlight the recent findings on pharmacological targets for NDD treatment. As high-throughput platforms in zebrafish research have rapidly developed in recent years, we also discuss the application prospects of these new technologies in future NDD research.

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“…HCAs exist extensively in the environment, such as high-protein thermally processed foods, cigarette smoke, polluted river water, the atmosphere, soil, etc. [2]. It is important to note that 2-Amino-3-methylimidazole[4,5-f]quinoline (IQ) is one of the most studied HCAs because of its highly carcinogenic and genotoxic nature [3].…”

Section: Introductionmentioning

confidence: 99%

“…It is important to note that 2-Amino-3-methylimidazole[4,5-f]quinoline (IQ) is one of the most studied HCAs because of its highly carcinogenic and genotoxic nature [3]. In 1993, the International Agency for Research on Cancer (IARC) classified IQ as "probably carcinogenic to humans" (group 2A carcinogens) [2]. The classification, exposure pathway, existence form, and mutagenic/carcinogenic mechanism of HCAs have been extensively studied in the early stage, but so far, the scientific research system for these issues is not complete [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Many HCAs have been proved to have prominent carcinogenic and mutagenic properties, which Toxins 2021, 13, 826 2 of 13 may bring potential harm to the human body and ecological environment; however, the pre-carcinogenic/mutagenic toxicity mechanisms of HCAs remain unclear. The previous literature has demonstrated the brain, colon and stomach toxicity of HCAs [6][7][8], and our previous study has illustrated that IQ is potentially neurotoxic to zebrafish (Danio rerio) [2]. However, unlike with other organs, relatively little is known about liver toxicity caused by IQ exposure, especially the potential harm to the liver and its mechanism before IQ induces liver cancer.…”

Section: Introductionmentioning

confidence: 99%

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2-Amino-3-Methylimidazo[4,5-f]quinoline Triggering Liver Damage by Inhibiting Autophagy and Inducing Endoplasmic Reticulum Stress in Zebrafish (Danio rerio)

Zhang

et al. 2021

Toxins

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It is important to note that 2-Amino-3-methylimidazole[4,5-f]quinoline (IQ) is one of the most common heterocyclic amines (HCAs), which is a class of mutagenic/carcinogenic harmful compounds mainly found in high-protein thermal processed foods and contaminated environments. However, the pre-carcinogenic toxicity of IQ to the liver and its mechanism are poorly understood, further research is needed. In light of this, we exposed zebrafish to IQ (0, 8, 80, and 800 ng/mL) for 35 days, followed by comprehensive experimental studies. Histopathological and ultrastructural analysis showed that hepatocytes were damaged. TUNEL results showed that IQ induced apoptosis of liver cells, the expression of apoptosis factor gene was significantly increased, and the expression of Bcl-2 protein was significantly decreased. In addition, upregulated expression of the 78-kDa glucose-regulated protein (GRP78) and C/EBP homologous protein (CHOP) and endoplasmic reticulum stress (ERS)-related factors transcription levels were elevated obviously, suggesting that IQ induced ERS. Decreased protein expression of autophagy-related 5 (Atg5)-Atg12, Beclin1, and LC3-II, increased protein expression of p62, and autophagy-related factors transcription levels were significantly decreased, suggesting that IQ inhibited autophagy. Overall, our research showed that the potential harm of IQ to the liver before the occurrence of liver cancer was related to ERS and its mediated autophagy and apoptosis pathways.

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Long-term exposure to 2-amino-3-methylimidazo[4,5-f]quinoline can trigger a potential risk of Parkinson's disease

Cited by 18 publications

References 79 publications

What we know about protein gut metabolites: Implications and insights for human health and diseases

What we know about protein gut metabolites: Implications and insights for human health and diseases

Advances of Zebrafish in Neurodegenerative Disease: From Models to Drug Discovery

2-Amino-3-Methylimidazo[4,5-f]quinoline Triggering Liver Damage by Inhibiting Autophagy and Inducing Endoplasmic Reticulum Stress in Zebrafish (Danio rerio)

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