2021
DOI: 10.3390/toxins13110826
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2-Amino-3-Methylimidazo[4,5-f]quinoline Triggering Liver Damage by Inhibiting Autophagy and Inducing Endoplasmic Reticulum Stress in Zebrafish (Danio rerio)

Abstract: It is important to note that 2-Amino-3-methylimidazole[4,5-f]quinoline (IQ) is one of the most common heterocyclic amines (HCAs), which is a class of mutagenic/carcinogenic harmful compounds mainly found in high-protein thermal processed foods and contaminated environments. However, the pre-carcinogenic toxicity of IQ to the liver and its mechanism are poorly understood, further research is needed. In light of this, we exposed zebrafish to IQ (0, 8, 80, and 800 ng/mL) for 35 days, followed by comprehensive exp… Show more

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“…The harmful dose of HCA has been reported mainly for in vitro and animal models, this due to the ethical restrictions of human studies and depend on the specific HCA. Recently, concentrations of 8 to 800 ng/mL of 2-Amino-3-methylimidazole [4,5-f] quinoline (one of the most common HCA) have been associated with damage to hepatocytes and induction of Parkinson's disease gen protein using zebrafish ( Danio rerio ) ( Li et al, 2021 , Li et al, 2021 ).…”
Section: Microbial Metabolites From Undigested Protein Colonic Fermen...mentioning
confidence: 99%
“…The harmful dose of HCA has been reported mainly for in vitro and animal models, this due to the ethical restrictions of human studies and depend on the specific HCA. Recently, concentrations of 8 to 800 ng/mL of 2-Amino-3-methylimidazole [4,5-f] quinoline (one of the most common HCA) have been associated with damage to hepatocytes and induction of Parkinson's disease gen protein using zebrafish ( Danio rerio ) ( Li et al, 2021 , Li et al, 2021 ).…”
Section: Microbial Metabolites From Undigested Protein Colonic Fermen...mentioning
confidence: 99%