“…The harmful dose of HCA has been reported mainly for in vitro and animal models, this due to the ethical restrictions of human studies and depend on the specific HCA. Recently, concentrations of 8 to 800 ng/mL of 2-Amino-3-methylimidazole [4,5-f] quinoline (one of the most common HCA) have been associated with damage to hepatocytes and induction of Parkinson's disease gen protein using zebrafish ( Danio rerio ) ( Li et al, 2021 , Li et al, 2021 ).…”