Long-term evolution of comorbidities and their disease burden in individuals with and without HIV as they age: analysis of the prospective AGEhIV cohort study

Boyd, Anders; Verburgh, Myrthe L; Reiss, Peter; Wit, Ferdinand W. N. M.; Valk, Marc van der; Schouten, Judith; Kooij, Katherine W.; Zoest, Rosan A van; Verheij, Eveline; Verboeket, Sebastiaan O; Elsenga, BC; Prins, Maria; Loeff, Maarten F. Schim van der; Grande, L. del; Olthof, V.; Agard, I.; Zaheri, S.; Hillebregt, M.M.J.; Ruijs, Y.; Benschop, DP; Berkaoui, A. El; Kootstra, Neeltje A.; Harskamp-Holwerda, AM; Maurer, Irma; Ruiz, MM Mangas; Girigorie, Arginell F.; Boeser-Nunnink, B.; Zikkenheiner, W; Trenité, S. Nolst; Geerlings, Suzanne E.; Goorhuis, Abraham; Hovius, Joppe W.; Nellen, F.J.B.; Poll, T. van der; Prins, Jan M.; Wiersinga, W. Joost; Vugt, M. van; Bree, Godelieve de; Eden, J. van; Hes, A.M.H. van; Pijnappel, F.J.J.; Weijsenfeld, A.M.; Smalhout, S.Y.; Duinen, Marlies van; Hazenberg, A.; Postema, P.G.; Bisschop, PHLT; Serlie, M.J.M.; Lips, Paul; Dekker, E.; Dekker, Natashe Lemos; Willemsen, J.M.R.; Vogt, Liffert

doi:10.1016/s2352-3018(22)00400-3

Cited by 11 publications

(5 citation statements)

References 19 publications

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“…For older HIV/AIDS patients, they are at greater risk of geriatric comorbidities and aging related problems. Verheij E et al [10] in a prospective cohort of 596 HIV-positive and 550…”

Section: Association Analysis Details Of Hospitalization Costs Of Hiv...mentioning

confidence: 98%

“…As HIV treatment approaches improve, new challenges and opportunities emerge. On the one hand, for people receiving ART, AIDS becomes a chronic disease with an increased risk of chronic comorbidity, including cardiovascular disease [7], depression [8], diabetes [9] and cancer [10], which also greatly increases the cost of treatment [11] for HIV/AIDS patients. For older HIV/AIDS patients, they are at greater risk of geriatric comorbidities and aging related problems.…”

Section: Association Analysis Details Of Hospitalization Costs Of Hiv...mentioning

confidence: 99%

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Analysis of influencing factors of hospitalization expenses of HIV/AIDS patients in a public hospital in Shenzhen

Yang

Hao

2023

Preprint

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Objective: To analyze the influencing factors of hospitalization costs of 700 HIV/AIDS patients in a hospital in Shenzhen. Methods: Descriptive statistics and multiple linear regression were used to analyze the influencing factors of hospitalization expenses, distinguish the patients with medicare and those without medicare, gray association was used to analyze the degree of association between various costs and hospitalization costs. Results: In 700 cases of HIV/AIDS patients, the influencing factor of total hospitalization cost is the length of hospital stay (LOS). The influencing factor of hospitalization cost of medical insurance and self-paying patients includes the LOS and the way of payment, the first three high expenses of hospitalization are western medicine, laboratory and physical therapy expenses. ursing and bed expenses have the highest correlation with hospitalization expenses, while the correlation of other items is high. Conclusion: To strengthen the supervision and management of hospitals, reduce the proportion of drugs and consumables, shorten the length of hospitalization, can effectively reduce the hospitalization cost and reduce the economic burden of patients' diseases

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“…For older HIV/AIDS patients, they are at greater risk of geriatric comorbidities and aging related problems. Verheij E et al [10] in a prospective cohort of 596 HIV-positive and 550…”

Section: Association Analysis Details Of Hospitalization Costs Of Hiv...mentioning

confidence: 98%

Section: Association Analysis Details Of Hospitalization Costs Of Hiv...mentioning

confidence: 99%

Analysis of influencing factors of hospitalization expenses of HIV/AIDS patients in a public hospital in Shenzhen

Yang

Hao

2023

Preprint

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“…People with HIV already live with one chronic health condition, and compared with age-matched adults without HIV, are more likely to accumulate additional comorbidities and live fewer disability-free years, despite effective treatment with ART [19]. Age-related comorbidities such as atherosclerotic cardiovascular disease, diabetes, and chronic kidney disease are more prevalent in this population [20,21], may manifest at a younger age and/or follow a more accelerated course than in the general population [22,23], and contribute to an estimated three-fold increase in mortality per additional comorbidity acquired [24]. Poor mental health is also commonly reported by people with HIV [8,[25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Associations between social determinants of health and comorbidity and multimorbidity in people of black ethnicities with HIV

Dominguez-Dominguez,

Campbell,

Barbini

et al. 2024

Aids

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Objective: Social Determinants of Health (SDH) are important determinants of long-term conditions and multimorbidity in the general population. The intersecting relationship between SDH and multimorbidity in people with HIV remains poorly studied. Design: Cross-sectional study investigating the relationships between eight socio-economic parameters and prevalent comorbidities of clinical significance and multimorbidity in adults of African ancestry with HIV aged 18–65 years in South London, UK. Methods: Multivariable logistic regression analysis was used to evaluate associations between SDH and comorbidities and multimorbidity. Results: Between September 2020 and January 2022, 398 participants (median age 52 years, 55% female) were enrolled; 85% reported at least one SDH and 72% had at least one comorbidity. There were no associations between SDH and diabetes mellitus or kidney disease, few associations between SDH (job and food insecurity) and cardiovascular or lung disease, and multiple associations between SDH (financial, food, housing and job insecurity, low educational level, social isolation, and discrimination) and poor mental health or chronic pain. Associations between SDH and multimorbidity mirrored those for constituent comorbidities. Conclusions: We demonstrate strong associations between SDH and poor mental health, chronic pain and multimorbidity in people of black ethnicities living with HIV in the UK. These findings highlight the likely impact of enduring socio-economic hardship in these communities and underlines the importance of holistic health and social care for people with HIV to address these adverse psychosocial conditions.

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“…Although HIV-related mortality has decreased in individuals treated with ART, older PWH experience more comorbidities and geriatric syndromes than their age-matched HIV-negative peers despite pharmacologic suppression of HIV viremia. 12 , 13 In addition, this population may experience more issues related to social isolation, stigma, mental health challenges, food insecurity and housing instability than the corresponding HIV-negative cohort. 14–17 …”

Section: Introductionmentioning

confidence: 99%

Treatment Regimens and Care Models for Older Patients Living with HIV: Are We Doing Enough?

Frey¹,

Johnston²,

Siegler³

2023

HIV

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With improved access to antiretroviral therapy throughout the world, people are aging with HIV, and a large portion of the global population of people with HIV (PWH) is now age 50 or older. Older PWH experience more comorbidities, aging-related syndromes, mental health challenges, and difficulties accessing fundamental needs than the population of older adults without HIV. As a result, ensuring that older PWH are receiving comprehensive healthcare can often be overwhelming for both PWH and the providers. Although there is a growing literature addressing the needs of this population, gaps remain in care delivery and research. In this paper, we suggest seven key components to any healthcare program designed to address the needs of older people with HIV: management of HIV, comorbidity screening and treatment, primary care coordination and planning, attention to aging related-syndromes, optimization of functional status, support of behavioral health, and improved access to basic needs and services. We review many of the difficulties and controversies related to the implementation of these components, which include the absence of screening guidelines for this population and the challenges of care integration, and we suggest key next steps.

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Long-term evolution of comorbidities and their disease burden in individuals with and without HIV as they age: analysis of the prospective AGEhIV cohort study

Cited by 11 publications

References 19 publications

Analysis of influencing factors of hospitalization expenses of HIV/AIDS patients in a public hospital in Shenzhen

Analysis of influencing factors of hospitalization expenses of HIV/AIDS patients in a public hospital in Shenzhen

Associations between social determinants of health and comorbidity and multimorbidity in people of black ethnicities with HIV

Treatment Regimens and Care Models for Older Patients Living with HIV: Are We Doing Enough?

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