Long-term evaluation of sperm parameters after coronavirus disease 2019 messenger ribonucleic acid vaccination

Diaz, Parris; Dullea, Alexandra; Patel, Mehul; Blachman‐Braun, Ruben; Reddy, Rohit; Khodamoradi, Kajal; Ibrahim, Emad; Bidhan, Joginder; Ramasamy, Ranjith

doi:10.1016/j.xfre.2022.07.007

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…Diaz et al. analyzed semen samples before mRNA vaccine vaccination and samples from 3 and 9 months after vaccination and found no significant differences in any parameter between time measurements [ 20 ]. It should be noted that only 12 volunteers participated in this study, and the small sample size was a limitation.…”

Section: Effects Of Covid-19 Vaccination On Male Fertilitymentioning

confidence: 99%

Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review

Wang,

et al. 2023

Annals of Medicine

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Although vaccination with the Coronavirus disease 2019 vaccine is important and effective in the prevention of SARS-CoV-2 infection, the public expressed concerns regarding the adverse effects of vaccine on fertility. Some reviews have focused on it, they have been unable to collect sufficient research data because of the earlier publication period. As relevant evidence has gradually increased, we reviewed these studies from the perspectives of males, females with or without pregnancy, and different vaccine types. The results suggest that although males may experience fluctuations in semen parameters within their physiological ranges after receiving the vaccine, it has not yet reached a level of influence on the partner’s pregnancy probability. As to female without pregnancy, it is believed that vaccination will not affect fertility; however, more research is needed to explore the short-term impact. Vaccination during any trimester is considered safe in pregnant women.

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Section: Effects Of Covid-19 Vaccination On Male Fertilitymentioning

confidence: 99%

Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review

Wang,

et al. 2023

Annals of Medicine

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“…Two of three oligospermic men at baseline became normospermic, and one remained oligospermic in the follow-up. These findings suggest no long-term effects of mRNA COVID-19 vaccination [ 80 ]. Consistent with these results, another study with a short follow-up examination (one spermatogenesis cycle) by Gonzalez et al included 45 healthy men.…”

Section: The Impact Of Covid-19 On Male Fertility Explained: Facts Ev...mentioning

confidence: 99%

COVID-19 and Male Infertility: Is There a Role for Antioxidants?

Kalfas,

Kaltsas,

Symeonidis

et al. 2023

Antioxidants

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Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), jeopardizes male fertility because of the vulnerability of the male reproductive system, especially the testes. This study evaluates the effects of the virus on testicular function and examines the potential role of antioxidants in mitigating the damage caused by oxidative stress (OS). A comprehensive PubMed search examined exocrine and endocrine testicular function alteration, the interplay between OS and COVID-19-induced defects, and the potential benefit of antioxidants. Although the virus is rarely directly detectable in sperm and testicular tissue, semen quality and hormonal balance are affected in patients, with some changes persisting throughout a spermatogenesis cycle. Testicular pathology in deceased patients shows defects in spermatogenesis, vascular changes, and inflammation. Acute primary hypogonadism is observed mainly in severely infected cases. Elevated OS and sperm DNA fragmentation markers suggest redox imbalance as a possible mechanism behind the fertility changes. COVID-19 vaccines appear to be safe for male fertility, but the efficacy of antioxidants to improve sperm quality after infection remains unproven due to limited research. Given the limited and inconclusive evidence, careful evaluation of men recovering from COVID-19 seeking fertility improvement is strongly recommended.

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“…All the studies were of reasonable quality. Of 24 studies, 9 (38%) studies were conducted in the United States and Western European countries [34][35][36][37][38][39][40][41][42], 5 (21%) in China [43][44][45][46][47], 1 (4%) in Indonesia [48], and 9 (38%) in the Middle Eastern countries [49][50][51][52][53][54][55][56][57]. In total, 3 (12%) studies used inactivated COVID-19 vaccines, 4 (17%) studies used viral-vectored vaccines, 8 (33%) studies used mRNA vaccines, and 3 (12%) studies included a combined analysis of multiple types of vaccines.…”

Section: Effects Of Sars-cov-2 Vaccination On Semen Quality: Availabl...mentioning

confidence: 99%

Effects of SARS-CoV-2 Vaccines on Sperm Quality: Systematic Review

Li,

Zhang,

Song

et al. 2023

JMIR Public Health Surveill

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Background The COVID-19 pandemic, caused by SARS-CoV-2, has triggered a global public health crisis of unprecedented proportions. SARS-CoV-2 vaccination is a highly effective strategy for preventing infections and severe COVID-19 outcomes. Although several studies have concluded that COVID-19 vaccines are unlikely to affect fertility, concerns have arisen regarding adverse events, including the potential impact on fertility; these concerns are plagued by limited and inconsistent evidence. Objective This review aims to provide a recent assessment of the literature on the impact of COVID-19 vaccines on male sperm quality. The possible impact of COVID-19 vaccines on fertility potential was also examined to draw a clearer picture and to evaluate the effects of COVID-19 on male reproductive health. Methods PubMed, Scopus, Web of Science, Embase, and Cochrane databases were searched from their inception to October 2023. Eligible studies included articles reporting SARS-CoV-2 vaccination and human semen quality and fertility, as well as the impact of vaccination on assisted reproductive technology treatment outcomes. The quality of cohort studies was assessed using the Newcastle-Ottawa Scale, and the quality of cross-sectional studies was assessed using the quality evaluation criteria recommended by the Agency for Healthcare Research and Quality. The systematic review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Results The initial literature search yielded 4691 records by searching 5 peer-reviewed databases (PubMed, Scopus, Web of Science, Embase, and Cochrane). Finally, 24 relevant studies were selected for our study. There were evident research inequalities at the regional level, with the United States and Western European countries contributing 38% (9/24) of the studies, Middle Eastern countries contributing 38% (9/24), China accounting for 21% (5/24), and Africa and South America accounting for none. Nonetheless, the overall quality of the included studies was generally good. Our results demonstrated that serious side effects of the COVID-19 vaccine are extremely rare, and men experience few problems with sperm parameters or reproductive potential after vaccination. Conclusions On the basis of the studies published so far, the COVID-19 vaccine is safe for male reproductive health. Obviously, vaccination is a wise option rather than experience serious adverse symptoms of viral infections. These instances of evidence may help reduce vaccine hesitancy and increase vaccination coverage, particularly among reproductive-age couples. As new controlled trials and prospective cohort studies with larger sample sizes emerge, the possibility of a negative effect of the COVID-19 vaccine on sperm quality must be further clarified.

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Long-term evaluation of sperm parameters after coronavirus disease 2019 messenger ribonucleic acid vaccination

Cited by 4 publications

References 5 publications

Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review

Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review

COVID-19 and Male Infertility: Is There a Role for Antioxidants?

Effects of SARS-CoV-2 Vaccines on Sperm Quality: Systematic Review

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