Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review

Wang, Chao; Wang, Min; Li, Guanjian; Song, Bing; Xing, Qiong; Cao, Yunxia

doi:10.1080/07853890.2023.2261964

Cited by 7 publications

(4 citation statements)

References 91 publications

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“…Also, regarding SARS-CoV-2 infections, we did not see an association with involuntary childlessness. Although shared immune determinants of SARS-CoV-2 with proteins involved in oocyte development led to concerns about a potential detrimental effect on female reproductive health [25], observational studies could not show infection-related differences in quantity or quality of oocytes [22,26,27]. Several studies found an association of SARS-CoV-2 infection with alterations of menstrual cycle length and bleeding intensity [28], which has been attributed to the function of angiotensin II and ACE 2 in both the infection and endometrium physiology.…”

Section: Discussionmentioning

confidence: 99%

SARS‐CoV‐2 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study

Dörr,

Güsewell,

Cusini

et al. 2024

Influenza Resp Viruses

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BackgroundThere is debate about the causes of the recent birth rate decline in high‐income countries worldwide. During the pandemic, concern about the effects on reproductive health has caused vaccine hesitancy. We investigated the association of SARS‐CoV‐2 vaccination and infection with involuntary childlessness.MethodsFemales in fertility age within a prospective multicenter cohort of healthcare workers (HCW) were followed since August 2020. Data on baseline health, SARS‐CoV‐2‐infection, and vaccination were obtained and regularly updated, in which serum samples were collected repetitively and screened for anti‐nucleocapsid and anti‐spike antibodies. In October 2023, participants indicated the presence of involuntary childlessness with onset during the pandemic, whereas those indicating an onset before the pandemic were excluded. The association of involuntary childlessness and SARS‐CoV‐2‐vaccination and infection was investigated using univariable and multivariable analysis. Sensitivity analysis was performed to compare those reporting involuntary childlessness with those birthing a child since 2020.ResultsOf 798 participants, 26 (3.2%) reported involuntary childlessness starting since the pandemic. Of the involuntary childless women, 73.1% (19/26) were vaccinated compared to 86.0% (664/772) without involuntary childlessness (p = 0.73). SARS‐CoV‐2 infection was reported by 76.9% (20/26) compared to 72.4% (559/772) of controls (p = 0.64). Neither SARS‐CoV‐2 vaccination (aOR 0.91 per dose, 95%CI 0.67–1.26) nor infection (aOR per infection 1.05, 95%CI 0.62–1.71) was associated with involuntary childlessness. Sensitivity analysis confirmed these results.ConclusionsAmong female HCW of fertility age, 3.2% indicated involuntary childlessness, which is comparable to pre‐pandemic data. No association between involuntary childlessness and SARS‐CoV‐2 vaccination or infection was found.

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Section: Discussionmentioning

confidence: 99%

SARS‐CoV‐2 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study

Dörr,

Güsewell,

Cusini

et al. 2024

Influenza Resp Viruses

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“…This could have led to pregnancies being postponed until after vaccination, as has been suggested for other countries. At present, the evidence is rapidly growing that the coronavirus vaccination itself cannot be directly and biologically linked to the decline in births and fertility (Wang et al, 2023; Zaçe et al, 2022). This unanimous opinion is supported by a growing number of studies with different designs and on male and female fertility (Aharon et al, 2022; Ba et al, 2023; Barda et al, 2022; Gonzalez et al, 2021; Morris, 2021; Reschini et al, 2022; Yang et al, 2023; Yildiz et al, 2023) and miscarriage (Yland et al, 2023; Zauche et al, 2021), including already some review articles (Rimmer et al, 2023; Wesselink et al, 2022; Zhang et al, 2023; Zhu et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

The remarkable ups and downs of birth rate in Switzerland 2020 to 2023 in a historical context

Le Vu,

Matthes,

Staub

2023

Preprint

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We follow population trends in the monthly birth rate in Switzerland almost up to the present and place the latest developments in a historical context. Birth rates in 2022 were the lowest since the 1870s, and the trend is continuing in 2023. The latest decline had already begun 1-2 years before Covid-19. Previous pandemics (1890, 1918, 1920, 1957) had led to a temporary decline in births ∽9 months after the epidemic peaks. With Covid-19, this appears more complex. During and shortly after the first two waves and shutdowns in 2020, there were more conceptions and thus excess birth rates in 2021, in all available subgroups except Italian-speaking Switzerland, and somewhat more pronounced among >30-year-old mothers and second parities. Possible reasons for the mini-boom include: The increased time at home during the shutdowns has – planned or not – led to more conceptions which has brought pregnancies forward; the corona virus was still circulat-ing too infrequently in this 1st phase of the pandemic to have a negative impact on pregnancies or fertility; at the end of the waves and shutdowns, the perceived end of the pandemic threat could have led to an optimistic mood and thus also more conceptions. The subsequent decline from January 2022 was stronger than the in-crease before. The first part of the decline in 2022 is most likely due to a negative rebound from the advance-ment of births in 2020/2021 and deliberately postponed pregnancies due to the start of the vaccination pro-gram. The second part of the decline in 2022 is associated with conceptions during the large Omicron wave in the winter of 2021/2022, when many people in Switzerland fell ill. In addition, prices have been rising and real wages falling since 2021, the global political situation has become more unstable, and a general change in values regarding the willingness to have children may also be underway. Following these observations at population level (with limited depth of variables), more in-depth studies must now follow to better under-stand the dynamic ups and downs in the birth rate in Switzerland in recent years.

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“…The Uppsala Monitoring Centre for pharmacovigilance recorded 2.9 million reports during 2021 and an additional 1.7 million reports in 2022 [41]. Despite evidence argue the safety of mRNA vaccine on the human fertility and maternal health [40,42,43]. In the last two years, Mansour et al [44] reported menstrual irregularities in women subsequent COVID-19 vaccination with poorly understood mechanisms.…”

Section: Parents' Vaccination Statusmentioning

confidence: 99%

Intention to vaccinate chronic disease children against COVID-19; a multicenter survey

Ghazy,

Elkhadry,

Elkaragy

et al. 2023

Egypt Pediatric Association Gaz

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Background Vaccination against severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) has gained recognition as a crucial strategy to prevent and reduce the risk of infection, including emerging variants, due to its proven safety, immunogenicity, and effectiveness. This study aimed to evaluate the vaccination hesitancy (VH) among Egyptian parents towards SARS-CoV-2 vaccination, specifically focusing on parents with chronically ill children. Method A multicentered cross-sectional survey was conducted at outpatient clinics of El-Raml Pediatric Hospital, Ministry of Health and Population (MOHP) in Alexandria, Alexandria Main University Hospital for Maternity and Children (AMUH), Al-Galaa Teaching Hospital, General Organization for Teaching Hospitals and Institutes (GOTHI) Cairo, and Pediatric Department, Menoufia University Hospital from May 1st till December 15th, 2022. Parents of children with chronic diseases were recruited using a simple random sampling technique to respond to the validated Arabic version of parental attitudes about childhood vaccination (PACV). Results In this study, we enrolled 527 caregivers, 55.4% of them were aged 30–39 years old, 85.2% were females, and 46.9% had chronic diseases. Commonly mentioned information sources included television and radio (69.8%), and social media (35.3%). Among the parents studied, 59.6% refused vaccination. The predictors of the PACV score were governorate, Menoufia (β = 11.30, 95%CI [5.32, 17.27], p < 0.001), study setting, Menoufia University Hospital (β = -20.07, 95%CI [-25.40, -14.75] and El-Raml Hospital (β = -10.74, 95%CI [-14.50, -6.98], p < 0.001), income; not enough and loans repaid (β = 3.18, 95%CI [0.54, 5.82], p = 0.018) and not enough and loans not repaid (β = 3.57,95%CI [0.08, 7.07], p = 0.045). Conclusions The study reveals geographic and economic factors as predictors of PACV, and emphasizes the need for region-specific interventions and financial barriers to improve vaccine acceptance and child well-being.

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Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review

Cited by 7 publications

References 91 publications

SARS‐CoV‐2 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study

SARS‐CoV‐2 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study

The remarkable ups and downs of birth rate in Switzerland 2020 to 2023 in a historical context

Intention to vaccinate chronic disease children against COVID-19; a multicenter survey

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