Long-term enhancement of evoked potentials in raccoon somatosensory cortex following co-activation of the nucleus basalis of Meynert complex and cutaneous receptors

Webster, Harry H.; Rasmusson, Douglas D.; Dykes, Robert W.; Schliebs, Reinhard; Schober, W; ̈ckner, G. Bru; Biesold, D

doi:10.1016/0006-8993(91)91300-p

Cited by 62 publications

(14 citation statements)

References 20 publications

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“…Activation of NBM plays an essential role in the depolarization of cortical neurons (Metherate and Ashe 1993) and in abolishing the overall synchronous activity in cortex that is associated with drowsiness (Buzsaki et al 1988;Detari et al 1999;Sarter and Bruno 2000; Wenk 1997). The desynchronized state is associated with mental arousal (Green and Arduini 1954;Vanderwolf 1969Vanderwolf , 1990) and attention (Muir et al 1992) and is correlated with heightened sensory processing (Bringmann and Klingberg 1990;Donoghue and Carroll 1987; Hars et al 1993;Mercado et al 2001;Metherate and Ashe 1991;Murphy and Sillito 1991;Sato et al 1987;Tremblay et al 1990;Webster et al 1991), improved working memory (Wrenn et al 1999), and improved cognition (Baxter and Chiba 1999;Everitt and Robbins 1997). Furthermore, animals in the desynchronized state exhibit sharpened sensory receptive fields during the alert state (Donoghue and Carroll 1987; McCormick and Prince 1986;Sato et al 1987) and attain a heightened capability for stimulus-induced plasticity (Baskerville et al 1997; Kilgard and Merzenich 1998; Maalouf et al 1998;Sachdev et al 1998).…”

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confidence: 99%

Activation of Nucleus Basalis Facilitates Cortical Control of a Brain Stem Motor Program

Berg¹,

Friedman²,

Schroeder³

et al. 2005

Journal of Neurophysiology

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. Activation of nucleus basalis facilitates cortical control of a brain stem motor program. J Neurophysiol 94: 699 -711, 2005. First published February 23, 2005 doi:10.1152/jn.01125.2004. We tested the hypothesis that activation of nucleus basalis magnocellularis (NBM), which provides cholinergic input to cortex, facilitates motor control. Our measures of facilitation were changes in the direction and time-course of vibrissa movements that are elicited by microstimulation of vibrissa motor (M1) cortex. In particular, microstimulation led solely to a transient retraction of the vibrissae in the sessile animal but to a full motion sequence of protraction followed by retraction in the aroused animal. We observed that activation of NBM, as assayed by cortical desynchronization, induced a transition from microstimulation-evoked retraction to full sweep sequences. This dramatic change in the vibrissa response to microstimulation was blocked by systemic delivery of atropine and, in anesthetized animals, an analogous change was blocked by the topical administration of atropine to M1 cortex. We conclude that NBM significantly facilitates the ability of M1 cortex to control movements. Our results bear on the importance of cholinergic activation in schemes for neuroprosthetic control of movement. I N T R O D U C T I O NNucleus basalis magnocellularis (NBM) of the basal forebrain forms extensive cholinergic projections throughout cortex (Casamenti et al. 1986; Johnston et al. 1979; Kurosawa et al. 1989;Rye et al. 1984;Saper 1984;Wenk et al. 1980;Woolf et al. 1983). Activation of NBM plays an essential role in the depolarization of cortical neurons (Metherate and Ashe 1993) and in abolishing the overall synchronous activity in cortex that is associated with drowsiness (Buzsaki et al. 1988;Detari et al. 1999;Sarter and Bruno 2000; Wenk 1997). The desynchronized state is associated with mental arousal (Green and Arduini 1954;Vanderwolf 1969Vanderwolf , 1990) and attention (Muir et al. 1992) and is correlated with heightened sensory processing (Bringmann and Klingberg 1990;Donoghue and Carroll 1987; Hars et al. 1993;Mercado et al. 2001;Metherate and Ashe 1991;Murphy and Sillito 1991;Sato et al. 1987;Tremblay et al. 1990;Webster et al. 1991), improved working memory (Wrenn et al. 1999), and improved cognition (Baxter and Chiba 1999;Everitt and Robbins 1997). Furthermore, animals in the desynchronized state exhibit sharpened sensory receptive fields during the alert state (Donoghue and Carroll 1987; McCormick and Prince 1986;Sato et al. 1987) and attain a heightened capability for stimulus-induced plasticity (Baskerville et al. 1997; Kilgard and Merzenich 1998; Maalouf et al. 1998;Sachdev et al. 1998). These elastic and plastic effects are mediated at least in large part by the neurotransmitter acetylcholine (Celesia and Jasper 1966; Kanai and Szerb 1965;Perry et al. 1999;Shute and Lewis 1967;Szerb 1967), prevalent in fibers from the NBM. In particular, the impact of pathological conditions like Alzheimer's disease, where ...

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confidence: 99%

Activation of Nucleus Basalis Facilitates Cortical Control of a Brain Stem Motor Program

Berg¹,

Friedman²,

Schroeder³

et al. 2005

Journal of Neurophysiology

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“…BFCS projections are capable of providing sufficient ACh release in the cortex to produce results similar to the ones obtained by the enhancement of evoked potentials [52,53] or single-unit responses [54] after pairing the cutaneous stimulation with direct stimulation of the BF. Control experiments using atropine, a muscarinic receptor blocker, either by systemic delivery or local iontophoretic administration, showed that the effects described above were specific and dependent upon the release of ACh.…”

Section: Bfcs Role In Adult Cortical Plasticity In Vivomentioning

confidence: 95%

What Has Intrinsic Signal Optical Imaging Taught Us About NGF-Induced Rapid Plasticity in Adult Cortex and Its Relationship to the Cholinergic System?

Prakash

Frostig

2005

Mol Imaging Biol

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Intrinsic signal optical imaging (ISI) is a high-resolution functional brain mapping technique that is being used to further our understanding of the neocortex and its interaction with drugs. Recent studies using combination ISI and in vivo pharmacology have advanced our insight into the actions of both acetylcholine and neurotrophins on inducing rapid and large-scale cortical plasticity. In particular, it appears that acetylcholine (ACh), nicotinic ACh receptors, nerve growth factor (NGF), and NGF receptors (TrkA and p75) are involved in an important feedback loop between the basal forebrain cholinergic system (BFCS) and the neocortex. Specifically, recent data suggest that NGF expressed in the cortex may act on multiple time scales on the BFCS: acutely to increase BFCS release of acetylcholine, intermediately to induce sprouting of BFCS axons, and long-term to change gene expression of BFCS neurons. In this article, advances in understanding the links in vivo between the BFCS, neocortex, nicotinic ACh receptors, and NGF are reviewed.

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“…The dopamine-acetylcholine pathway might be the neuropharmacological substrate of incentive motivation, as well as the way for the brain to represent uncertainty Anim Cogn (2012) 15:443-459 451 communication between neurons (Rasmusson 2000). For instance, ten pairings of basal forebrain stimulation with mechanical stimulation of the skin enhance the somatosensory evoked potential in the raccoon (Webster et al 1991b). Whisker displacement immediately after stimulating the basal forebrain of rats produces long-lasting facilitation of the whisker response, and this effect is more pronounced in the first trial than in subsequent trials (Howard and Simons 1994).…”

Section: The Dual Process Of Demodularisation-remodularisationmentioning

confidence: 99%

Modularity of mind and the role of incentive motivation in representing novelty

Anselme

2012

Anim Cogn

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Animal and human brains contain a myriad of mental representations that have to be successfully tracked within fractions of a second in a large number of situations. This retrieval process is hard to explain without postulating the massive modularity of cognition. Assuming that the mind is massively modular, it is then necessary to understand how cognitive modules can efficiently represent dynamic environments-in which some modules may have to deal with change-induced novelty and uncertainty. Novelty of a stimulus is a problem for a module when unknown, significant stimuli do not satisfy the module's processing criteria-or domain specificity-and cannot therefore be included in its database. It is suggested that the brain mechanisms of incentive motivation, recruited when faced with novelty and uncertainty, induce transient variations in the domain specificity of cognitive modules in order to allow them to process information they were not prepared to learn. It is hypothesised that the behavioural transitions leading from exploratory activity to habit formation are correlated with (and possibly caused by) the organism's ability to counter novelty-induced uncertainty.

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Long-term enhancement of evoked potentials in raccoon somatosensory cortex following co-activation of the nucleus basalis of Meynert complex and cutaneous receptors

Cited by 62 publications

References 20 publications

Activation of Nucleus Basalis Facilitates Cortical Control of a Brain Stem Motor Program

Activation of Nucleus Basalis Facilitates Cortical Control of a Brain Stem Motor Program

What Has Intrinsic Signal Optical Imaging Taught Us About NGF-Induced Rapid Plasticity in Adult Cortex and Its Relationship to the Cholinergic System?

Modularity of mind and the role of incentive motivation in representing novelty

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