Long‐term emollient therapy improves xerosis in children with atopic dermatitis

Boralévi, F.; Aroman, M. Saint; Delarue, Alain; Raudsepp, H.; Kaszuba, Andrzej; Bylaitė, Matilda; Tiplica, G.S.

doi:10.1111/jdv.12314

Cited by 61 publications

(72 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite the fact that no statistical analyses were planned, and therefore not performed, to compare the effects of the two emollients, these results clearly show that continuous treatment with an emollient is required to provide a clinical benefit. These observations are in line with a previously published study which showed that stopping emollient treatment results in a relapse of AD, but improvement was observed when emollient treatment was restarted …”

Section: Discussionsupporting

confidence: 93%

The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomized controlled study

Tiplica

Boralévi

Konno

et al. 2018

Acad Dermatol Venereol

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomized controlled study

Tiplica

Boralévi

Konno

et al. 2018

Acad Dermatol Venereol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Application of both formulations, lotion and cream in G1, as well as the amount of PIPJ and natural lipids may have influenced the course of SCH, since no significant changes in SCH were found in G2 [53]. The SCH values in G1 were comparable with SCH values in AD children of the same age treated with an emollient [54,55]. However, the SCH levels in both groups were lower than the SCH values reported for nonatopic children [44].…”

Section: Discussionmentioning

confidence: 50%

Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Schario

Lünnemann²,

Stroux³

et al. 2014

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Background: Dry skin reflects a skin barrier defect which can lead to atopic dermatitis. Little is known about the distinct effects of emollient use in children with dry skin and atopic predisposition. Objectives: We investigated the effects of daily application of pressed ice plant juice (PIPJ)-based emollients and petrolatum-based emollients. Methods: Children aged 2-6 years with dry skin and atopic predisposition were randomized into 2 groups: group 1 received emollients containing PIPJ and natural lipids, while group 2 received petrolatum-based emollients. Skin condition and biophysical properties of the skin barrier were assessed at inclusion and weeks 4, 12 and 16. Results: Skin condition improved significantly in all children. Comparing the groups, children treated with emollients containing PIPJ showed significantly higher stratum corneum hydration values and significantly lower transepidermal water loss values at week 16 on the forearm and forehead. A significant decrease in skin pH was noted in group 2 on the forearm and forehead; group 1 showed a stable course. Conclusion: Early intervention with emollients in children with dry skin condition and atopic predisposition may improve their skin condition during daily emollient application. PIPJ-based formulations may be helpful to maintain skin barrier integrity.

show abstract

“…Certain moisturizers could improve skin barrier function in AE and reduce skin susceptibility to irritants. It was clearly demonstrated that long‐term emollient therapy improves AE‐associated xerosis . Simple stand‐alone emollient application for one week may improve mild‐to‐moderate AE .…”

Section: Basic Therapy Of Disturbed Skin Barrier Function and Emolliementioning

confidence: 99%

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

Wollenberg

Barbarot

Bieber³

et al. 2018

Acad Dermatol Venereol

786

943

View full text Add to dashboard Cite

This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This first part of the guideline covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy, whereas the second part covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions. Management of AE must consider the individual clinical variability of the disease; highly standardized treatment rules are not recommended. Basic therapy is focused on treatment of disturbed barrier function by hydrating and lubricating topical treatment, besides further avoidance of specific and unspecific provocation factors. Topical anti-inflammatory treatment based on glucocorticosteroids and calcineurin inhibitors is used for flare management and for proactive therapy for long-term control. Topical corticosteroids remain the mainstay of therapy, whereas tacrolimus and pimecrolimus are preferred in sensitive skin areas and for long-term use. Topical phosphodiesterase inhibitors may be a treatment alternative when available. Adjuvant therapy includes UV irradiation, preferably with UVB 311 nm or UVA1. Pruritus is targeted with the majority of the recommended therapies, but some patients may need additional antipruritic therapy. Antimicrobial therapy, systemic anti-inflammatory treatment, immunotherapy, complementary medicine and educational intervention will be addressed in part II of the guideline.

show abstract

Long‐term emollient therapy improves xerosis in children with atopic dermatitis

Abstract: Long-term therapy with emollient is effective and well tolerated for the treatment of xerosis in children with atopic dermatitis.

Cited by 61 publications

References 22 publications

The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomized controlled study

The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomized controlled study

Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

Contact Info

Product

Resources

About