Long Term Efficacy of Radioiodine Treatment in Hyperthyroidism

Bakos, Bence; Takács, István; Nagy, Zsolt; Kósa, János P.; Balla, Bernadett; Tobiás, Bálint; Halászlaki, Csaba; Szili, Balázs; Lakatos, Péter L.

doi:10.1055/s-0033-1334884

Cited by 3 publications

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“…Conversely, RAI treatment can achieve long-term cure in 93-97% of patients, but euthyroidism cannot be restored in many cases and most of the patients with Graves' disease and a relevant fraction of patients with toxic goiters (approximately one-third) will develop hypothyroidism [5][6][7]. Additionally, RAI is associated with side effects such as salivary gland and lacrimal gland disorders [5,[8][9][10]. Furthermore, the ionizing radiation might require a hospital stay of several days, depending on the local national (e.g., Swiss) laws of radiation protection.…”

Section: Introductionmentioning

confidence: 99%

Early Timing of Thyroidectomy for Hyperthyroidism in Graves’ Disease Improves Biochemical Recovery

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Early Timing of Thyroidectomy for Hyperthyroidism in Graves’ Disease Improves Biochemical Recovery

et al. 2017

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The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats

Zhou

Yang

et al. 2015

Hormones and Behavior

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Dosimetry-guided radioiodine therapy of hyperthyroidism: long-term experience and implications for guidelines

Leitha

Schartel²,

Hurtl³

et al. 2020

Nuclear Medicine Communications

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Background Long-term follow-up after radioactive iodine therapy (RIT) for Graves’ disease and toxic thyroid autonomy is incompletely addressed by current guidelines. We retrospectively analyzed the clinical course of 1233 out of 1728 consecutive Graves’ disease (n = 536) and thyroid autonomy (n = 1192) patients after dosimetry-guided RIT to optimize follow-up. Methods Patients were referred between 1990 and 2018; follow-up was monitored according to available electronic registers with medical reports, including autopsies from 9 hospitals and 10 residential care homes. Results In total, 495/1728 cases were censored because of incomplete 6-month follow-up data. The conversion rates to hypothyroidism in Graves’ disease and different forms of thyroid autonomy can be deconvoluted into two follow-up periods: first year after RIT and afterward. The conversion rate in Graves’ disease was significantly higher than that in all thyroid autonomy subgroups during the first year but almost identical afterwards. Thyroxine substitution started between 10 and 7900 days after RIT at thyroid stimulating hormone between 0.11 and 177 µU/ml. Conclusions We advise earlier (2–3 weeks) first follow-up checks after RIT in all Graves’ disease patients and thyroid autonomy under antithyroid drugs (ATD) and re-checks every 2–4 weeks until conversion to hypothyroidism during the first year. The first check in thyroid autonomy without ATD should be after 3–4 weeks with re-checks every 4–6 weeks. After 1 year, both groups can be re-checked every 4–6 months over the next 5 years. The success rate of RIT in thyroid autonomyincreases with age but the history of RIT is rapidly lost during follow-up.

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Long Term Efficacy of Radioiodine Treatment in Hyperthyroidism

Abstract: Compared to the available data published in the literature, the success rate of the treatment is fairly high confirming the effectiveness of our protocol.

Cited by 3 publications

References 6 publications

Early Timing of Thyroidectomy for Hyperthyroidism in Graves’ Disease Improves Biochemical Recovery

Early Timing of Thyroidectomy for Hyperthyroidism in Graves’ Disease Improves Biochemical Recovery

The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats

Dosimetry-guided radioiodine therapy of hyperthyroidism: long-term experience and implications for guidelines

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