Long-Term Efficacy of Methylphenidate Immediate-Release for the Treatment of Childhood ADHD

Maia, Carlos Renato Moreira; Cortese, Samuele; Caye, Arthur; T, Deakin; Polanczyk, Guilherme Vanoni; Polanczyk, Carísi Anne; Rohde, Luís Augusto

doi:10.1177/1087054714559643

Cited by 52 publications

(23 citation statements)

References 59 publications

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“…In contrast to migraine, ADHD has an early onset and a pooled worldwide prevalence of 5.3% in child and adolescent populations [ 9 ]. The current treatment strategies do not completely remove the symptoms in both children and adults and approximately 30% of all patients do not respond to medical treatment or develop serious adverse reactions [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Comorbidity of migraine with ADHD in adults

et al. 2018

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BackgroundMigraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy population. Assessing the comorbidity between ADHD and migraine may clarify the etiopathology of both diseases. Thus, the objective is to assess whether migraine (with and without visual disturbances) and ADHD are comorbid disorders.MethodsParticipants from the Danish Blood Donor Study (N = 26,456, age 18–65, 46% female) were assessed for migraine and ADHD using the ASRS ver 1.1 clinically validated questionnaire and self-reported migraine in a cross-sectional study. Logistic regression was used to examine the comorbidity between migraine and ADHD, and their associated endophenotypes.ResultsMigraine was strongly associated with ADHD (OR = 1.8, 95% CI = 1.5–2.1), (238/6152 vs 690/19,376). There was a significant interaction between age and gender, with comorbidity increasing with age and female sex. Post-hoc analysis showed that migraine with visual disturbance was generally associated with a marginally higher risk of ADHD and this was independent of ADHD endophenotypes.ConclusionMigraine and ADHD were demonstrated to be comorbid disorders; the association with ADHD was most prominent for participants with migraine with visual disturbances. Future studies will elucidate which genetic and environmental factors contribute to migraine-ADHD comorbidity.

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Section: Introductionmentioning

confidence: 99%

Comorbidity of migraine with ADHD in adults

et al. 2018

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“…Attention‐deficit/hyperactivity disorder (ADHD) is characterized by pervasive and impairing levels of inattention and/or hyperactivity/impulsivity (H/I; American Psychiatric Association, ), imposing an enormous burden on society (Maia et al, ) and affecting around 3.4% of children around the world (Polanczyk, Salum, Sugaya, Caye, & Rohde, ). Methylphenidate is currently the most often prescribed drug to treat ADHD (Storebo et al, ), and it has been used for over 50 years to treat children and adolescents.…”

Section: Introductionmentioning

confidence: 99%

Assessing risk of bias in randomized controlled trials of methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)

Raissa

Swardfager

Salum

et al. 2017

Int J Methods Psych Res

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To test how reliable the tool recommend by Cochrane Collaboration for assessing risk of bias systematic reviews of randomized clinical trials is in the context of methylphenidate for children and adolescents with attention deficit hyperactivity disorder. Confirmatory factor analysis was used to evaluate a unidimensional model for the 7 indicators, applied to 184 Randomized Clinical Trial (RCTs) within a 2015 Cochrane systematic review titled "Methylphenidate for children and adolescents with attention deficit hyperactivity disorder." A unidimensional model resulted in excellent adequacy indices, but only 2 indicators had very high factor loadings and low measurement errors. In terms of content, the 7 indicators showed poor reliability (ω = 0.642); however, the set of indicators was precise in evaluating studies with a high amount of bias risk. The Cochrane model of risk of bias as it is, exhibited good fit indices but the majority of the items were not reliable to adequately capture risk of bias in the context of clinical trials of methylphenidate for ADHD.

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“…Además, existen múltiples propuestas psicoeducativas e incluso vías de intervención por medio del uso de la informática (García, Hernández, & Cruz, 2016). El tratamiento farmacológico, aunque ha sido el que mayor evidencia empírica ha tenido a su favor, ha sido criticado por no atender otros síntomas psicológicos que interfieren en la vida de las personas diagnosticadas con TDAH además de ser un tratamiento que muchas veces no es aceptado por las familias (Maia et al, 2014). Por otro lado, las técnicas de modificación de conductas así como los entrenamientos cognitivos han demostrado avances en algunas áreas del trastorno pero aún existe la necesidad de seguir evaluando su efectividad de forma empírica (Scandar & Bunge, 2017).…”

Section: Tdahunclassified

NeuroArte un programa de fortalecimiento de las funciones ejecutivas en niños con TD AH

Gómez

Cuadros

slwis³

2018

I&D

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Objetivo. Determinar el efecto de un programa de estimulación neurocognitivo musical sobre las Funciones Ejecutivas (FE) de niños colombianos diagnosticados con TDAH.Metodología. Específicamente, se estudiaron las FE control inhibitorio, memoria de trabajo y planificación. Con este fin, se seleccionó una muestra de 12 niños escolarizados (11 niños y 1 niña) de 10 años, diagnosticados con TDAH para participar en el programa Estimularte. Estimularte es un programa novedoso de estimulación cognitivo musical, se diseño tomando como punto de partida los elementos del entrenamiento musical activo y pasivo como herramienta para fortalecer las FE. Para evaluar las FE antes y después de la administración del programa, se utilizó la Evaluación Neuropsicológica de las Funciones Ejecutivas en Niños (ENFEN). Las funciones evaluadas fueron: planificación, memoria de trabajo, control inhibitorio y flexibilidad cognitiva.Resultados. Se evidenciaron que hay diferencias estadísticamente significativas debido a un incremento de la media después de la intervención con el programa EstimulArte, lo que repercutió en un desempeño significativamente mejor de los niños tras haber sido parte del programa en el control inhibitorio, memoria de trabajo y planificación. Esto significo una mejora en cuanto a la capacidad de modificar, corregir errores o incorporar nuevas conductas en función del desarrollo de un plan de acción para alcanzar un objetivo. Asimismo, hubo un incremento en la capacidad de manipular y retener simultáneamente la información relevante para la ejecución de la tarea.Conclusión. Se concluye que el Programa NeuroArte y la estimulación musical se convierten en una herramienta alternativa para apoyar los procesos de desarrollo de las Funciones Ejecutivas, aunque se debe seguir investigando su efectividad en niños con TDAH, se ha demostrando que la terapia musical estimula procesos cognitivos que pueden beneficiar a esta población.

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Long-Term Efficacy of Methylphenidate Immediate-Release for the Treatment of Childhood ADHD

Abstract: MPH-IR is efficacious for childhood ADHD for periods longer than 12 weeks.

Cited by 52 publications

References 59 publications

Comorbidity of migraine with ADHD in adults

Comorbidity of migraine with ADHD in adults

Assessing risk of bias in randomized controlled trials of methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)

NeuroArte un programa de fortalecimiento de las funciones ejecutivas en niños con TD AH

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