Long-term effects of laparoscopic sleeve gastrectomy, gastric bypass, and adjustable gastric banding on type 2 diabetes

Abbatini, Francesca; Rizzello, Mario; Casella, Giovanni; Alessandri, Giorgio; Capoccia, Danila; Leonetti, Frida; Basso, Nicola

doi:10.1007/s00464-009-0715-9

Cited by 237 publications

(144 citation statements)

References 29 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…Restrictive LAGB and LSG procedures do not result in significant malabsorption and show high efficacy for weight loss. [20][21][22] All 3 types of procedures used in the present study were performed laparoscopically by the same surgical team at the Medical University of Bialystok Clinical Hospital.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of bariatric procedures based on selected laboratory parameters of patients from rural areas in Polish population

et al. 2017

View full text Add to dashboard Cite

Background. Rural areas in Poland are inhabited by over 15 million people, i.e. 39.5% of Polish population, including about 5 million rural residents in the Podlaskie province. The incidence of obesity is associated with increased prevalence of obesity-related conditions. Studies that have been conducted do not confirm the efficacy of conservative treatment of obesity, but show that bariatric procedures produce the best longterm results.

show abstract

Section: Discussionmentioning

confidence: 99%

Effectiveness of bariatric procedures based on selected laboratory parameters of patients from rural areas in Polish population

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This proposed difference between groups is a conservative estimate based on the results from the only 2 previous studies comparing the effect of gastric restriction versus RYGB procedures on insulin sensitivity using the hyperinsulinemic clamp procedure (43,44). In both studies, insulin-stimulated glucose disposal was more than 200% greater after RYGB than after restrictive surgical procedures.…”

Section: Statisticsmentioning

confidence: 99%

Gastric bypass and banding equally improve insulin sensitivity and β cell function

Bradley¹,

Conte²,

et al. 2012

View full text Add to dashboard Cite

Bariatric surgery in obese patients is a highly effective method of preventing or resolving type 2 diabetes mellitus (T2DM); however, the remission rate is not the same among different surgical procedures. We compared the effects of 20% weight loss induced by laparoscopic adjustable gastric banding (LAGB) or Roux-en-Y gastric bypass (RYGB) surgery on the metabolic response to a mixed meal, insulin sensitivity, and β cell function in nondiabetic obese adults. The metabolic response to meal ingestion was markedly different after RYGB than after LAGB surgery, manifested by rapid delivery of ingested glucose into the systemic circulation, by an increase in the dynamic insulin secretion rate, and by large, early postprandial increases in plasma glucose, insulin, and glucagon-like peptide-1 concentrations in the RYGB group. However, the improvement in oral glucose tolerance, insulin sensitivity, and overall β cell function after weight loss were not different between surgical groups. Additionally, both surgical procedures resulted in a similar decrease in adipose tissue markers of inflammation. We conclude that marked weight loss itself is primarily responsible for the therapeutic effects of RYGB and LAGB on insulin sensitivity, β cell function, and oral glucose tolerance in nondiabetic obese adults.

show abstract

“…1). The medium-term efficacy of LSG is superior to laparoscopic AGB (LAGB) (1,146,168) (11,31,66,175,192), the long-term efficacy of LSG may be less favorable. Two recent studies demonstrate significant weight regain after 5 yr (17, 75), though this could be related to variation in surgical technique; the LSG procedure has evolved over time and, on the whole, sleeve diameter has been tightened.…”

Section: The Gut Energy Homeostasis and Obesitymentioning

confidence: 99%

Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: understanding weight loss and improvements in type 2 diabetes after bariatric surgery

Scott

Batterham

2011

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Obesity increases the likelihood of diseases like type 2 diabetes (T2D), heart disease, and cancer, and is one of the most serious public health problems of this century. In contrast to ineffectual prevention strategies, lifestyle modifications, and pharmacological therapies, bariatric surgery is a very effective treatment for morbid obesity and also markedly improves associated comorbidities like T2D. However, weight loss and resolution of T2D after bariatric surgery is heterogeneous and specific to type of bariatric procedure performed. Conventional mechanisms like intestinal malabsorption and gastric restriction do not fully explain this, and potent changes in appetite and the enteroinsular axis, as a result of anatomical reorganization and altered hormonal, neuronal, and nutrient signaling, are the portended cause. Uniquely these signaling changes appear to override vigorous homeostatic defenses of stable body weight and compelling self-gratifying motivations to eat and to reverse defects in beta-cell function and insulin sensitivity. Here we review mechanisms of weight loss and T2D resolution after Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy bariatric surgery, two markedly different procedures with robust clinical outcomes.

show abstract

Long-term effects of laparoscopic sleeve gastrectomy, gastric bypass, and adjustable gastric banding on type 2 diabetes

Cited by 237 publications

References 29 publications

Effectiveness of bariatric procedures based on selected laboratory parameters of patients from rural areas in Polish population

Effectiveness of bariatric procedures based on selected laboratory parameters of patients from rural areas in Polish population

Gastric bypass and banding equally improve insulin sensitivity and β cell function

Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: understanding weight loss and improvements in type 2 diabetes after bariatric surgery

Contact Info

Product

Resources

About