Long-term effects of in ovo exposure to an environmentally relevant dose of atrazine on the thyroid gland of Caiman latirostris

Galoppo, G.H.; Tavalieri, Yamil Ezequiel; Schierano-Marotti, Gonzalo; Osti, Mario Raúl; Luque, Enrique H.; Muñoz-de-Toro, Mónica

doi:10.1016/j.envres.2020.109410

Cited by 18 publications

(6 citation statements)

References 77 publications

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“…The oviducts were dissected and processed until paraffin embedded. Morphometric analysis was performed following the same procedure used by Galoppo et al, 2020. Graphs: END significantly increases the mesenchymal area of the oviduct occupied by glands in prepubertal juvenile caimans.…”

Section: Acknowledgmentsmentioning

confidence: 99%

Effects of agricultural pesticides on the reproductive system of aquatic wildlife species, with crocodilians as sentinel species

Tavalieri

Galoppo

Canesini

et al. 2020

Molecular and Cellular Endocrinology

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Section: Acknowledgmentsmentioning

confidence: 99%

Effects of agricultural pesticides on the reproductive system of aquatic wildlife species, with crocodilians as sentinel species

Tavalieri

Galoppo

Canesini

et al. 2020

Molecular and Cellular Endocrinology

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“…This finding suggests that, despite being related to growth and development regulation, the levels of these two hormones remained unaltered after the 35-day atrazine exposure. However, previous studies found an organizational dysfunction in the thyroid gland in exposed juveniles reptiles (Galoppo et al 2020) and demasculinization in juvenile fish and reptiles, suggesting that atrazine exposure altered aromatase activity and induced excessive estrogen production (Hayes et al 2011).…”

Section: Discussionmentioning

confidence: 92%

Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish

Silva

Gregório²,

Freitas³

et al. 2023

Biosci. J.

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Synthetic herbicides have been intensively used in weed control, although often involved in environmental contamination, critically affecting non-target species. However, never was investigated the effect of commercial formulation using atrazine on developing juvenile fish exposed for 35 days. Juveniles (Astyanax altiparanae) (n = 600) were assigned to the following ATZ-exposed groups: 0 (CTR-control), 0.56 (ATZ0.56), 1.00 (ATZ1.00), 1.66 (ATZ1.66) and 11.66 (ATZ11.66) μg/L. We found a 36.6% decrease in juvenile survival rate in the ATZ11.66 group compared to control and other groups. Juveniles from ATZ11.66 also showed hyperglycemia and increased cortisol levels. Increased the imbalance oxidative with an increase in malondialdehyde (MDA) and Carbonylated proteins levels markers in muscle, gills, and liver. We also found increased activity of the antioxidant enzymes superoxide dismutase (SOD) in gills and SOD and catalase (CAT) in muscles from ATZ11.66 fish, and increased glutathione S-transferase (GST) activities in the liver from all exposed groups compared to control. The morphological consequences of this were loss of secondary lamella integrity, increased mucus-secreting cells, hyperplasia, and lamellar fusion, as well as increased aneurysms percentage. The liver showed vascular congestion associated with endothelial hyperplasia, steatosis, and a decrease in the nuclei percentage. Our results showed that exposure to a commercial formulation of ATZ at 11.66 μg/L can be causing an imbalance in the oxidative markers and morphological damages and decreased survival in a juvenile Neotropical species of great ecological relevance and commercial interest.

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“…In many cases, the interaction of pesticides with the hormonal (endocrine) system of wildlife has led to impaired reproduction and gradual population decline of certain species [211]. It has several consequences on the endocrine system such as demasculinization and feminization of gonads [194] of male vertebrates, control of ovarian growth exerted by the neurohormones secreted at the eyestalk of the crab Neohelice granulata [212], and long-term histofunctional changes in the thyroid gland on the crocodilian specie of C. latirostris during embryonic development [213]. The endocrine-disrupting activity of these pesticides and their metabolites (e.g., dialkyl phosphates) has been observed in different animals.…”

Section: Effect On Animalsmentioning

confidence: 99%

Endocrine-Disrupting Compounds: An Overview on Their Occurrence in the Aquatic Environment and Human Exposure

Pironti

Ricciardi

Proto

et al. 2021

Water

126

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Endocrine-disrupting compounds (EDCs) as emerging contaminants have accumulated in the aquatic environment at concentration levels that have been determined to be significant to humans and animals. Several compounds belong to this family, from natural substances (hormones such as estrone, 17β-estradiol, and estriol) to synthetic chemicals, especially pesticides, pharmaceuticals, and plastic-derived compounds (phthalates, bisphenol A). In this review, we discuss recent works regarding EDC occurrence in the aquatic compartment, strengths and limitations of current analytical methods used for their detection, treatment technologies for their removal from water, and the health issues that they can trigger in humans. Nowadays, many EDCs have been identified in significant amounts in different water matrices including drinking water, thus increasing the possibility of entering the food chain. Several studies correlate human exposure to high concentrations of EDCs with serious effects such as infertility, thyroid dysfunction, early puberty, endometriosis, diabetes, and obesity. Although our intention is not to explain all disorders related to EDCs exposure, this review aims to guide future research towards a deeper knowledge of EDCs’ contamination and accumulation in water, highlighting their toxicity and exposure risks to humans.

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Long-term effects of in ovo exposure to an environmentally relevant dose of atrazine on the thyroid gland of Caiman latirostris

Cited by 18 publications

References 77 publications

Effects of agricultural pesticides on the reproductive system of aquatic wildlife species, with crocodilians as sentinel species

Effects of agricultural pesticides on the reproductive system of aquatic wildlife species, with crocodilians as sentinel species

Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish

Endocrine-Disrupting Compounds: An Overview on Their Occurrence in the Aquatic Environment and Human Exposure

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