Long Term Effective Half-lives for Lead-210 and Polonium-210 in Selected Organs of the Male Rat

Torvik, E; Pfitzer, Emil A.; Jg, Kereiakes; Blanchard, R.L.

doi:10.1097/00004032-197401000-00009

Cited by 7 publications

(3 citation statements)

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“…Des travaux ont porté sur le *'%'O dans le cadre d'études sur l'effet des émetteurs alpha sur le métabolisme animal (Rencova et al, 1997 ;Stannard et Casarett, 1964). La demi-vie biologique du 210Po dans les animaux est de l'ordre de quelques mois et varie suivant les organes et les espèces (Torvik et al, 1974). La décroissance du 210Pb au sein des organismes peut être une source de 2'0Po pour les espèces ayant une espérance de vie relativement longue, comme dans le cas du bétail (Lapham et O/., 1989).…”

Section: Transfert Du 210po Aux Animauxunclassified

Comportement du²¹⁰Po en milieu terrestre : revue bibliographique

Coppin

Roussel-Debet

2004

Radioprotection

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Cette synthèse bibliographique décrit le com ortement du polonium-210 dans l'environnement terrestre. Les sources du "' Po dans l'atmosphère varient notamment avec la localisation géographique et la présence ou l'absence d'activités minières. Dans les sols, le polonium, du fait de son origine aîmosphérique, est concentré dans les premiers centimètres. C'est un élément peu mobile qui s'adsorbe sur les surfaces minérales et peut (co)précipiter avec les (oxy)h droxydes métalliques ou sous forme de sulfure. La voie d'entrée majoritaire du ''$0 dans la végétation est le dépôt foliaire qui n'est pas, ou peu, suivi d'incorporation ou de translocation. Le transfert du ""Po aux animaux s'effectue principalement par ingestion, avec des facteurs de transfert relativement élevés. Dans les hydrosystèmes dulçaquicoles, le ''%O est généralement immobilisé sous forme de Po(IV) insoluble eüou associé à la phase particulaire ou colloïdale. Le plancton, les invertébrés et les poissons concentrent le *'"Po, surtout dans les tissus mous. Le polonium, radioélément naturel omniprésent dans l'environnement, est susceptible d'induire pour l'homme une exposition significative par rapport à d'autres radionucléides naturels ou artificiels. Les études -essentiellement des mesures in situqui lui sont consacrées restent très descriptives, aussi, des travaux expérimentaux permettant de mieux comprendre et de modéliser son comportement dans le milieu terrestre seraient utiles. &SuMÉABSTRACT "@Po hehaviour in terrestrial environment: a review.This hibliographical review illustrates the behaviour of 210 polonium in the terrestrial environment. Sources of "%o in the atmosphere vary especiallg with the geographical localization and the occurrence or the absence of mining activities. In soils, polonium hecause of its atmospheric origin, is concentrated in the first upper centinieters. 'lbPo is rather immobile and adsorbed on mineral surfaces; it can (co)precipitate with metallic (0xi)hydroxides or in the form of sulphide. The main transfer pathway of 2i0Po to vegetation is foliar deposit, which is not, or only slightly, followed by incorporation or translocation. 2i0Po is transferred to animals mainlg by ingestion, with relatively high transfer factors. In freshwaters, ""Po is generally immobile in the form of insoluble Po(IV) a n a o r associated with the particulate or colloidal phase. Plankton. invertebrates and f ï h concentrate the 2"k'o, especially in soft tissues. Polonium, which is an omnipresent natural radionuclide, is likely to occasion a significant exposure ta man, compared with other natural or artificial radioisotopes. Nearly al1 studies derive from in situ measurements and are very descriptive, therefore experimental work aiming at a hetter knowledge and modeling of its hehaviour in the terrestrial environment would he useful.' IRSN. Service d'érudes et de recherche' radioSc«logiqiic\ en Iahoratnire. Lahnratoire de iadinécologie expérinientale, C.E. Cadarache. B.P. 13, 131 15 S3iiit~Paul-L27~Uuinnce Cedex. Fraiicc

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Section: Transfert Du 210po Aux Animauxunclassified

Comportement du²¹⁰Po en milieu terrestre : revue bibliographique

Coppin

Roussel-Debet

2004

Radioprotection

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“…Mean total deposition of lead was calculated to be 30.5%. 210 1 njection of 25 J,Ci Pb into adult rats resulted in a lead half-Iie in bone of 64-109 days (Torvik et al, 1974). After Lv.…”

Section: Route and Dosagementioning

confidence: 99%

Evaluation of the carcinogenic risk of chemicals to humans

Hamilton¹

1979

Science of The Total Environment

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“…Some have used 203Pb Kostial et al, 1973;Momcilovic and Kostial, 1974) and others 210Pb (Horiuchi and Horiuchi, 1958;Castellino and Aloj, 1964;Lucas and Stanford, 1967;Cohen, 1970;Torvik et al, 1974). In no case, however, has an attempt been made to follow the precise distribution of lead in all tissues during the few days immediately after administration.…”

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Retention, distribution, and excretion of lead by the rat after intravenous injection.

Morgan¹,

Holmes²,

Evans³

1977

Occupational and Environmental Medicine

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The distribution and excretion of lead was studied during a period of about a week after a single intravenous injection of 203Pb as chloride accompanied by less than 1 ,tg of lead carrier. The peak concentration in venous blood was reached after about an hour when it contained 35 to 40 % of the administered activity. The subsequent decline in concentration was much more rapid than is observed in man. The main storage organs were the kidneys and bone. Initially, 20 % of the dose could be accounted for in the kidneys and the biological half-life was about 100 hours. The level in bone built up rapidly at first and then more slowly. After a week, between 25 and 30°, of the dose was present in bone.Petrol engine exhaust aerosols labelled with 203Pb have been administered to volunteers by Chamberlain et al. (1975) to study their deposition in the respiratory tract and the absorption of the associated lead. In complementary investigations, similar aerosols were administered to rats to' study, in greater detail than is possible with volunteers, the distribution of absorbed lead at various times. To provide, for comparative purposes, information on the metabolism of lead introduced directly into the blood stream rats were injected intravenously with 203Pb in the form of chloride. The results of these investigations are described in this report and an account of the absorption and metabolism of lead administered to rats in exhaust particulates will be given elsewhere.

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Long Term Effective Half-lives for Lead-210 and Polonium-210 in Selected Organs of the Male Rat

Cited by 7 publications

References 0 publications

Comportement du²¹⁰Po en milieu terrestre : revue bibliographique

Comportement du²¹⁰Po en milieu terrestre : revue bibliographique

Evaluation of the carcinogenic risk of chemicals to humans

Retention, distribution, and excretion of lead by the rat after intravenous injection.

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Long Term Effective Half-lives for Lead-210 and Polonium-210 in Selected Organs of the Male Rat

Cited by 7 publications

References 0 publications

Comportement du210Po en milieu terrestre : revue bibliographique

Comportement du210Po en milieu terrestre : revue bibliographique

Evaluation of the carcinogenic risk of chemicals to humans

Retention, distribution, and excretion of lead by the rat after intravenous injection.

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Product

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Comportement du²¹⁰Po en milieu terrestre : revue bibliographique

Comportement du²¹⁰Po en milieu terrestre : revue bibliographique