During the last century, potato (Solanum tuberosum L.) has become a worldwide elementary staple food. The key reason for this process is the high nutritional value of potato as a carbohydrate source, storability, and ease and divergent uses. Breeding programmes resulted in new cultivars with improved yield potential (Brown 2011). In spite of a significant biological progress during the recent decades, actual yields in many countries are unsatisfactory and fail to rise further. Between 2004 and 2013, the world average yield increased from 17.7 t/ha to 19.5 t/ha (FAOSTAT 2016). The estimated potential yields for Poland (PL) and the Czech Republic (CZ) are 39.7 t/ha, 47.7 t/ha (Supit et al. 2010), while the actual yields during 2003-2013 ranged from 15-24 t/ha and 23-30 t/ha for PL and CZ, respectively, and from 15-24 t/ha for Albania (AL) (FAOSTAT 2016).The key reason of much lower real yields is not rooted only in the course of weather, but also results from low efficiency of applied nitrogen (N) fertilizer. The current mineral nutrition management in the Central Europe crop production is N-oriented, almost neglecting other nutrients, like phosphorus (P) and potassium (K). As a result, harvested yields are highly year-to-year variable (Grzebisz et al. Potato yield is affected by an interaction between nitrogen (N) and potassium (K) supply. This hypothesis was verified in a series of field experiments conducted during 2010-2013 in Albania (AL), Czech Republic (CZ) and Poland (PL). The two-factorial experiment was founded on relative scales of K (0, 50, 100, and 150%), and N application rates (75% and 100%) of the recommended doses, which were country-specific. The average tuber yield was doubled for AL, increased by 50% for PL, and by 15% for the CZ in response to K and N interaction. These differences are caused by an increase in the apparent nitrogen efficiency (ANE), which rose significantly by the progressive Krates. Maximum average ANE of 90 kg tubers/kg N was recorded in AL; it was 2-fold lower in CZ. Top average apparent potassium efficiency (AKE) of 65 kg tubers/kg K was recorded in PL; it was 4-times lower in CZ. The relationships between AKE and ANE clearly demonstrate the tight interaction between the N and K, and its effects on potato yield. However, a sound K application management should be adjusted to the local edaphic and climatic conditions.