Long-term effect of low energy laser irradiation on infarction and reperfusion injury in the rat heart

Yaakobi, Tali; Shoshany, Yariv; Levkovitz, Sara; Rubin, Ofer; Haim, Shlomo A. Ben; Oron, Uri

doi:10.1152/jappl.2001.90.6.2411

Cited by 57 publications

(77 citation statements)

References 36 publications

(47 reference statements)

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“…Thus, it may be postulated that even when the contralateral side to the stroke is irradiated at an optimal power density of 7.5 mW/cm 2 and the ischemic zone to suboptimal energy, the overall beneficial biological effect is evident. Indeed it has been shown previously that LLLT applied to the ischemic heart was beneficial when the entire lateral part (and not only the ischemic infracted zone) of the heart was irradiated by the laser [6][7][8]. Furthermore, it has been shown in non-ischemic skeletal muscles that there was a significant upregulation of antioxidant and heat shock proteins (neuroprotective molecules) by LLLT at similar power density and wavelength to the laser used in the present study [13].…”

Section: Discussionsupporting

confidence: 62%

“…In an experimental model of the infarcted heart it was previously demonstrated that LLLT had a profound cardioprotective effect, resulting in a 50-70% reduction in infarct size 4-6 weeks post left descending coronary artery chronic occlusion. This phenomenon was partially attributed to a significant increase in the number of undamaged mitochondria and ATP content, as well as inducible heat shock proteins and catalase (in the serum) in infarcted laserirradiated rats and dogs as compared to non-irradiated ones [5][6][7][8]. LLLT has also been shown to biomodulate processes in the nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Transcranial application of low‐energy laser irradiation improves neurological deficits in rats following acute stroke

Taboada¹,

Ilić²,

Leichliter-Martha³

et al. 2006

Lasers Surg Med

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138

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Background and Objectives: Low-level laser therapy (LLLT) has been shown to have beneficial effects on ischemic skeletal and heart muscles tissues. The aim of the present study was to approve the effectiveness of LLLT treatment at different locations on the brain in acute stroked rats. Study Design/Materials and Methods: Stroke was induced in 169 rats that were divided into four groups: control non-laser and three laser-treated groups where laser was employed ipsilateral, contralateral, and both to the side of the induced stroke. Rats were tested for neurological function. Results: In all three laser-treated groups, a marked and significant improvement in neurological deficits was evident at 14, 21, and 28 days post stroke relative to the nontreated group. Conclusions: These observations suggest that LLLT applied at different locations in the skull and in a rather delayed-phase post stroke effectively improves neurological function after acute stroke in rats.

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Transcranial application of low‐energy laser irradiation improves neurological deficits in rats following acute stroke

Taboada¹,

Ilić²,

Leichliter-Martha³

et al. 2006

Lasers Surg Med

Self Cite

138

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show abstract

“…Low-level laser therapy (LLLT) has been investigated as an alternative treatment for stroke, and LLLT has been shown to have a neuroprotective effect, 38,39 while regulating several biological processes. [40][41][42] Light can penetrate several tissues, including both the scalp and skull, and reach into the brain.…”

Section: Mechanisms Of Tllltmentioning

confidence: 99%

Transcranial Low-Level Laser (Light) Therapy for Brain Injury

Thunshelle

Hamblin

2016

Photomedicine and Laser Surgery

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Background: Low-level laser therapy (LLLT) or photobiomodulation (PBM) is a possible treatment for brain injury, including traumatic brain injury (TBI). Methods: We review the fundamental mechanisms at the cellular and molecular level and the effects on the brain are discussed. There are several contributing processes that have been proposed to lead to the beneficial effects of PBM in treating TBI such as stimulation of neurogenesis, a decrease in inflammation, and neuroprotection. Both animal and clinical trials for ischemic stroke are outlined. A number of articles have shown how transcranial LLLT (tLLLT) is effective at increasing memory, learning, and the overall neurological performance in rodent models with TBI. Results: Our laboratory has conducted three different studies on the effects of tLLLT on mice with TBI. The first studied pulsed against continuous laser irradiation, finding that 10 Hz pulsed was the best. The second compared four different wavelengths, discovering only 660 and 810 nm to have any effectiveness, whereas 732 and 980 nm did not. The third looked at varying regimens of daily laser treatments (1, 3, and 14 days) and found that 14 laser applications was excessive. We also review several studies of the effects of tLLLT on neuroprogenitor cells, brain-derived neurotrophic factor and synaptogenesis, immediate early response knockout mice, and tLLLT in combination therapy with metabolic inhibitors. Conclusions: Finally, some clinical studies in TBI patients are covered.

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“…The beneficial effect of LLLT has been revealed in the infarcted heart model of rat and dogs, which showed reduction of 50-70% of infarct size in 4-6 weeks post-infarction (Oron et al, 2001a;Oron et al, 2001b;Yaakobi et al, 2001). A study by Tuby et al (2006) irradiated the heart with LLLT in both intact and post infarction rats.…”

Section: Pre-conditioning With Lllt Reduces Damage After Heart Attackmentioning

confidence: 99%

Pre-Conditioning with Low-Level Laser (Light) Therapy: Light before the Storm

et al. 2014

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h Pre-conditioning by ischemia, hyperthermia, hypothermia, hyperbaric oxygen (and numerous other modalities) is a rapidly growing area of investigation that is used in pathological conditions where tissue damage may be expected. The damage caused by surgery, heart attack, or stroke can be mitigated by pre-treating the local or distant tissue with low levels of a stress-inducing stimulus, that can induce a protective response against subsequent major damage. Low-level laser (light) therapy (LLLT) has been used for nearly 50 years to enhance tissue healing and to relieve pain, inflammation and swelling. The photons are absorbed in cytochrome(c) oxidase (unit four in the mitochondrial respiratory chain), and this enzyme activation increases electron transport, respiration, oxygen consumption and ATP production. A complex signaling cascade is initiated leading to activation of transcription factors and up-and down-regulation of numerous genes. Recently it has become apparent that LLLT can also be effective if delivered to normal cells or tissue before the actual insult or trauma, in a pre-conditioning mode. Muscles are protected, nerves feel less pain, and LLLT can protect against a subsequent heart attack. These examples point the way to wider use of LLLT as a pre-conditioning modality to prevent pain and increase healing after surgical/medical procedures and possibly to increase athletic performance.

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Long-term effect of low energy laser irradiation on infarction and reperfusion injury in the rat heart

Cited by 57 publications

References 36 publications

Transcranial application of low‐energy laser irradiation improves neurological deficits in rats following acute stroke

Transcranial application of low‐energy laser irradiation improves neurological deficits in rats following acute stroke

Transcranial Low-Level Laser (Light) Therapy for Brain Injury

Pre-Conditioning with Low-Level Laser (Light) Therapy: Light before the Storm

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