Long-term depot medroxyprogesterone acetate (Depo-Provera) use in inner-city adolescents

Weight gain, adiposity, and eating behaviors among adolescent females on depot medroxyprogesterone acetate (DMPA)

“…17 Weight gain on DMPA significantly impacts both method continuation and restart rates in adolescent girls. 2,3,18 In the current study differences in the amount, character, and risk factors for weight gain were seen between black and white adolescent girls. More research is necessary to explore these differences.…”

“…2 Nearly one third of adolescents who begin DMPA do not receive a second injection at 3 months, one half do not receive a third injection at 6 months, and three quarters discontinue use by 12 months. 3 Only 9% of adolescents who discontinue because of weight gain will restart DMPA, compared to 80% who discontinue owing to missed appointments. 3 Strategies to prevent weight gain on DMPA are hampered by a paucity of information about its predictive factors and underlying mechanisms.…”

“…3 Only 9% of adolescents who discontinue because of weight gain will restart DMPA, compared to 80% who discontinue owing to missed appointments. 3 Strategies to prevent weight gain on DMPA are hampered by a paucity of information about its predictive factors and underlying mechanisms. Moreover, studies examining risk factors associated with weight gain among adolescents are limited.…”

Associations among Body Composition, Androgen Levels, and Human Immunodeficiency Virus Status in Adolescents

“…Use of exogenous steroids such as the hormone contraceptive medroxyprogesterone is associated with weight gain, primarily fat [35]. Progesterone-only contraceptives have androgenic (as well as anti-androgenic) properties that can cause increase in appetite with resulting increases in weight gain.…”

Prescribing DMPA to Teens

“…However, the continuation rate after 1 year is quite low. 1 Weight gain is one of the most common reasons for discontinuation. Several recent studies have looked at the issue of weight gain among DPMA users.…”