Long-Term Consumption of Whey Hydrolysate Formula by Lactating Women Reduces the Transfer of .BETA.-Lactoglobulin into Human Milk.

Fukushima, Yoichi; Kawata, Yoichi; Onda, Takekazu; Kitagawa, Michihiro

doi:10.3177/jnsv.43.673

Cited by 7 publications

(8 citation statements)

References 11 publications

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“…Most of the reviewed studies on human milk searched only bovine β-LG [ 20 , 21 , 22 , 23 , 24 , 25 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 42 ]. Other researchers investigated both β-LG and αS1-casein [ 37 , 38 , 41 ], while Pastor-Vargas [ 39 ] monitored β-LG along with other food allergens.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies using radioimmunoassay techniques [ 21 , 22 , 24 , 25 ] detected β-LG in human milk samples in concentrations between 4.4 and 800 ng/mL, the latter being the maximum reported level so far. ELISA techniques have been employed by several authors [ 17 , 20 , 23 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 41 , 42 ]. The maximum value detected for β-LG in human milk using this technique was 150 ng/mL [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…The influence of cow’s milk serving size (ranging between 200 and 1500 mL) on the quantities of allergen detected in breast milk could not be demonstrated in two studies [ 24 , 32 ]. However, the results obtained by Fukushima et al [ 33 ] suggested that β-LG concentrations in breast milk are related to long-term consumption of cow’s milk. These authors found that the consumption of whey hydrolysate formula by lactating women over a considerable time reduces the transfer of β-LG into their milk and that this low level can be maintained even after inadvertent ingestion of cow’s milk [ 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, the results obtained by Fukushima et al [ 33 ] suggested that β-LG concentrations in breast milk are related to long-term consumption of cow’s milk. These authors found that the consumption of whey hydrolysate formula by lactating women over a considerable time reduces the transfer of β-LG into their milk and that this low level can be maintained even after inadvertent ingestion of cow’s milk [ 33 , 34 ]. Likewise, Monti et al [ 25 ] inferred an increase in β-LG with a diet rich in cow’s milk proteins.…”

Section: Resultsmentioning

confidence: 99%

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Cow’s Milk Antigens Content in Human Milk: A Scoping Review

Franco

Fente

Sánchez

et al. 2022

Foods

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The functionality of breast milk in terms of immunity is well-known. Despite this, a significant proportion of breastfed infants exhibit sensitization to different potentially allergenic proteins and clinical reactivity (including anaphylaxis) early in life and before the introduction of complementary feeding for the first time. The potential induction of early oral tolerance to overcome early allergic sensitization through exposure to allergens in breast milk also remains controversial and not yet well-established. The objective of this scoping review is to provide a critical appraisal of knowledge about the content of cow’s milk antigens in human milk. The amount of dietary derived milk antigens found in human milk and the analytical methodologies used to detect and quantify these antigens, the allergic status of the mother, the stage of lactation, the time of sampling (before or after ingestion of food), and the impact of human milk allergen on the infant were the outcomes that were assessed. Allergy risk was explored in all reviewed studies and could help to better elucidate its role in the context of allergic disease development. According to the included literature, we can conclude that there are mainly fragments derived from bovine proteins in human milk, and the presence of potentially allergenic molecules is greater in the milk of mothers with an allergic tendency. A clear relationship between maternal diet and allergen content in breast milk could not be firmly concluded though. Also, infants receiving milk from human milk banks, where donor milk is pasteurized for preservation, may be subject to greater risk of allergy development, especially for β-lactoglobulin.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Cow’s Milk Antigens Content in Human Milk: A Scoping Review

Franco

Fente

Sánchez

et al. 2022

Foods

View full text Add to dashboard Cite

show abstract

“…-lactoglobulin and OVA, which are derived from cow's milk and eggs, frequently appeared in the breast milk when ingested by lactating women. 7,8) These food antigens found in breast milk include intact proteins and sometimes cause allergic reactions in exclusively breast-fed infants. 9) Husby et al found 10.5 mg OVA/ml in the sera from seven of eight healthy adults 2-3 h after ingestion of 60 ml raw egg and 500 ml milk.…”

mentioning

confidence: 99%