Long-term consequences in the offspring born by rats with experimental preeclampsia

Muzyko, E. A.; Перфилова, В. Н.; Kustova, M. V.; Suvorin, K. V.; Tyurenkov, I. N.; Petrov, V. I

doi:10.14300/mnnc.2020.15084

Medical news of the North Caucasus

2020

DOI: 10.14300/mnnc.2020.15084

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Long-term consequences in the offspring born by rats with experimental preeclampsia

E. A. Muzyko¹,

В. Н. Перфилова²,

M. V. Kustova³

et al.

Abstract: АД-артериальное давление ДНК-дезоксирибонуклеиновая кислота Кд-коэффициент дискриминации ОХ-общий холестерин РНК-рибонуклеиновая кислота ТГ-триглицериды ХС ЛПВП-холестерин липопротеинов высокой плотности ЭП-экспериментальная преэклампсия

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2023

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Effect of non-selective NO-synthase inhibitor administered during pregnancy on the development of the cerebral cortex in 20-day-old rat pups

Rusak,

Maksimovich,

Bon

et al. 2023

jour

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Aim. To study the morphology of neurons in the cerebral cortex of rat pups on day 20 under conditions of administration of a nitric oxide synthase inhibitor (NOS) during placentation.Materials and methods. Outbred white female rats (n = 12) were randomly divided into 2 groups of 6 rats each. On the 11th day of pregnancy, the experimental group received a single intramuscular injection of N(omega)-nitro-L-arginine methyl ester (L NAME) at a dose of 25 mg/kg, in the control group – once intramuscularly 0.9% NaCl solution. Born rat pups were randomly selected one from the mother. On the 20th day, after medical euthanasia, the brain was collected. In the anterior part of the frontal cortex, we studied the density and area of neurons, the size and shape of perikarya and the severity of their staining with toluidine blue. Results. In the experimental group of 20-day-old rat pups, compared to the control group, the density and area of neurons were less by 10% (p > 0.05) and 22% (p > 0.05), respectively, the shape of the perikarya also changed to elongated, the elongation factor increased by 0.3 units. (p < 0.05) and there was a sixfold increase in the proportion of hyperchromic neurons (p < 0.05), hyperchromic wrinkled (p < 0.001) neurons appeared, which were absent in control animals. Conclusion. Morphological changes in neurons of the cerebral cortex in rat pups born from females who received a NOS inhibitor during placentation may be a consequence of a decrease in the formation of nitric oxide in the neurons themselves and in the endothelium of the vessels supplying the brain

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Effect of non-selective NO-synthase inhibitor administered during pregnancy on the development of the cerebral cortex in 20-day-old rat pups

Rusak,

Maksimovich,

Bon

et al. 2023

jour

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Long-term consequences of acute toxic prenatal hypoxia induced by sodium nitrite in rat experiments

Savateeva-Lyubimova,

Sivak,

Aleksandrov

et al. 2023

Урал. мед. журнал

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Introduction. Gestational hypoxia plays an important role in fetal development, as it causes the development of oxidative stress and delayed psychomotor development. The aim of the study was to evaluate the prenatal effect of sodium nitrite on indices characterizing orienting and exploratory activity, mental activity and the degree of hypoxia in rat offspring. Materials and methods. Acute hypoxia was modeled by administration of sodium nitrite at a dose of 30 mg/kg intramuscularly to five pregnant rats during 16–19 days of gestation. Five females constituted a control group. In 50 born rats, orientation and exploration activity, cognitive functions, intensity of lipid peroxidation and glycolysis were studied. Results. The offspring of females that underwent acute hypoxia significantly lagged behind in the positive dynamics of body weight gain compared to control individuals. Thirty-day-old rats showed a pronounced disorder of the structure of behavioral pattern, learning process and long-term memory, increased content of diene conjugates, malonic dialdehyde and the level of lactate dehydrogenase activity in blood. Discussion. It was found that offspring whose mothers suffered acute hypoxia of toxic genesis developed pronounced behavioral disorders of psychomotor agitation and cognitive dysfunction characterized by decreased learning ability and impaired long-term memory. The content of primary and secondary products of lipid peroxidation and lactate dehydrogenase was increased in rats. The development of cellular oxidative stress under conditions of intrauterine hypoxia leads to oxygen deficiency in the fetus and a switch from tissue respiration to glycolysis, which underlies CNS damage. Conclusion. It was shown that sodium nitrite administration during the period from the 16th to the 19th day of gestation caused hyperactivity, depressed emotional status, and decreased orienting and exploratory activity and the ability to learn and retain a memory trace in rat offspring. Increased levels of diene conjugates and malonic dialdehyde, lactate dehydrogenase activity were observed in rats.

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Long-term consequences in the offspring born by rats with experimental preeclampsia

Cited by 2 publications

References 13 publications

Effect of non-selective NO-synthase inhibitor administered during pregnancy on the development of the cerebral cortex in 20-day-old rat pups

Effect of non-selective NO-synthase inhibitor administered during pregnancy on the development of the cerebral cortex in 20-day-old rat pups

Long-term consequences of acute toxic prenatal hypoxia induced by sodium nitrite in rat experiments

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