Effect of non-selective NO-synthase inhibitor administered during pregnancy on the development of the cerebral cortex in 20-day-old rat pups
T. S. Rusak,
N. Ye. Maksimovich,
E. I. Bon
et al.
Abstract:Aim. To study the morphology of neurons in the cerebral cortex of rat pups on day 20 under conditions of administration of a nitric oxide synthase inhibitor (NOS) during placentation.Materials and methods. Outbred white female rats (n = 12) were randomly divided into 2 groups of 6 rats each. On the 11th day of pregnancy, the experimental group received a single intramuscular injection of N(omega)-nitro-L-arginine methyl ester (L NAME) at a dose of 25 mg/kg, in the control group – once intramuscularly 0.9% Na… Show more
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