Long-term biocompatibility of a corrodible peripheral iron stent in the porcine descending aorta

Peuster, Matthias; Hesse, Carola; Schloo, Tirza; Fink, Christoph; Beerbaum, Philipp; Schnakenburg, Christian von

doi:10.1016/j.biomaterials.2006.05.029

Cited by 498 publications

(360 citation statements)

References 38 publications

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“…These results suggest that the iron implant corrosion acted moderately inflammatory mainly due to the presence of the implant and its insoluble particulate corrosion products rather than by the production of excess iron ion ions. than for functional testing of stents 11,25 . However, it is currently not possible to perform whole genome gene expression analysis in rabbits and a much higher effort would be required for testing statistically significant numbers of implants in pigs.…”

Section: Molecular Characterization Of the Implant-tissue Interactionmentioning

confidence: 99%

“…The mechanical stability of resorbable polymeric materials is not satisfactory and their degradation can provoke inflammation, whereas with metal alloys superior mechanical strength can be achieved [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] . Whereas magnesium stents tend to degrade too rapidly, this appears not to be the case for iron implants [25][26][27][28][29][30][31] . To evaluate candidate materials appropriate testing procedures are required.…”

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confidence: 99%

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Histological and molecular evaluation of iron as degradable medical implant material in a murine animal model

Mueller

Arnold

Badar

et al. 2012

J Biomedical Materials Res

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Section: Molecular Characterization Of the Implant-tissue Interactionmentioning

confidence: 99%

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confidence: 99%

Histological and molecular evaluation of iron as degradable medical implant material in a murine animal model

Mueller

Arnold

Badar

et al. 2012

J Biomedical Materials Res

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“…8 Iron, on the other hand, degrades too slowly for many applications and produces voluminous corrosion products, causing an increase in the volume of the implant. 9,10 Zinc (Zn) was recently suggested as an alternative degradable metal or alloy base. 11,12 The toxicity of zinc is higher than that of iron or magnesium, and concerns have therefore been raised regarding its biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Zn-Mg and Zn-Ag Degradation Mechanism Under Biologically Relevant Conditions

Törne

Khan

Örnberg

et al. 2017

Surface Innovations

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Zinc (Zn) alloys form a promising new class of biodegradable metals that combine suitable mechanical properties with the favorable degradation properties of pure zinc. However, the current understanding of the influence of alloying elements on the corrosion of zinc alloys, in biologically relevant media, is limited. The authors studied the degradation of three alloys, zinc-4 wt% silver (Ag), zinc-0·5 wt% magnesium (Mg) and zinc-3 wt% magnesium by in situ electrochemical impedance spectroscopy (EIS). After exposure for 1 h or 30 d, the samples were characterized by infrared spectroscopy and scanning electron microscopy. The presence of secondary phases in the alloy microstructure induced selective corrosion and increased the degradation rate. EIS analysis revealed an increase in surface inhomogeneity already at short (hours) immersion times. The microgalvanic corrosion of the zinc-silver alloy resulted in enrichment of the AgZn 3 phase at the sample surface. The enrichment of silver and potential release of AgZn 3 particles may result in complications during the tissue regeneration. The zinc-magnesium alloy surface was depleted of the magnesium-rich phase after 8-12 d. The selective dissolution caused local precipitation of corrosion products and a thicker corrosion layer with larger pore size consistent with increased corrosion rate.

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“…Pure iron (over 99.5%) has high elasticity modulus and excellent radial strength to make a stent with thin strut [18]. And iron is theoretically expected to easily break during or after the expansion due to its yield strength and tensile strength being similar, but as the result of in vivo experiment, the strut with the thickness of 100 -120 μm was expanded with the pressure of 3 -10 atm and no destruction of stent was observed at all [19].…”

Section: Metalmentioning

confidence: 99%

Biodegradable stent

Kwon¹,

Kim²,

Kim³

et al. 2012

JBiSE

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The bare metal stent (BMS) used in the blood vessel caused the restenosis after the operation due to formation and proliferation of neointimal. Recently, as a method to overcome the problems of BMS, drug eluting stent (DES) is developed and being applied to human body which has drug reducing restenosis applied on the metal surface. DES has the advantage of greatly reducing the restenosis after the operation; however, metal stent remains in the body after the drug is released causing issues such as late thrombosis and restenosis so that currently the attention is increasing for biodegradable materials that reduce restenosis and thrombosis by degrading as a certain amount of time passes after the drug is released by the stent material. In this review, the study trend of biodegradable stent will be explained.

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Long-term biocompatibility of a corrodible peripheral iron stent in the porcine descending aorta

Cited by 498 publications

References 38 publications

Histological and molecular evaluation of iron as degradable medical implant material in a murine animal model

Histological and molecular evaluation of iron as degradable medical implant material in a murine animal model

Zn-Mg and Zn-Ag Degradation Mechanism Under Biologically Relevant Conditions

Biodegradable stent

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