Biodegradable stent

Kwon, Doo Yeon; Kim, Jae Il; Kim, Da Yeon; Kang, Hwi Ju; Lee, Bong; Lee, Kang Woo; Kim, Moon Suk

doi:10.4236/jbise.2012.54028

Cited by 32 publications

(17 citation statements)

References 61 publications

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“…Bioresorption behavior of PLLA PLLA, a semicrystalline polymer (maximum crystallinity =70%) with the highest glass transition temperature, Tg, has relatively high tensile properties among the general biodegradable polymers (23). The Tg of a polymer is the temperature at which the reversible transition in amorphous regions within a semicrystalline polymer from a hard and relatively brittle state into a viscous or rubbery state occurs.…”

Section: Mechanical Properties Of Polymer-based Brsmentioning

confidence: 99%

Mechanical behavior of polymer-based vs. metallic-based bioresorbable stents

et al. 2017

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Bioresorbable scaffolds (BRS) were developed to overcome the drawbacks of current metallic drug-eluting stents (DES), such as late in-stent restenosis and caging of the vessel permanently. The concept of the BRS is to provide transient support to the vessel during healing before being degraded and resorbed by the body, freeing the vessel and restoring vasomotion. The mechanical properties of the BRS are influenced by the choice of the material and processing methods. Due to insufficient radial strength of the bioresorbable material, BRS often required large strut profile as compared to conventional metallic DES. Having thick struts will in turn affect the deliverability of the device and may cause flow disturbance, thereby increasing the incidence of acute thrombotic events. Currently, the bioresorbable poly-l-lactic acid (PLLA) polymer and magnesium (Mg) alloys are being investigated as materials in BRS technologies. The bioresorption process, mechanical properties, observations and clinical outcomes of PLLA-based and Mg-based BRS will be examined in this review.

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Section: Mechanical Properties Of Polymer-based Brsmentioning

confidence: 99%

Mechanical behavior of polymer-based vs. metallic-based bioresorbable stents

et al. 2017

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“…The related "tissue trauma" is repeated when the stent is removed surgically after the disease has been cured. Biodegradable polymer stents have been getting focused attention due to the recognition that the stents are only temporarily needed in the body and they may have similar flexibility, elasticity as the body tissues [82][83]. PLA (Ttrans linked with Tg) and PCL (Ttrans linked with Tm) were used first as stent materials.…”

Section: Applicationsmentioning

confidence: 99%

Shape Memory Systems with Biodegradable Polyesters

Kocsis

Siengchin

2015

Biodegradable Polyesters

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“…The challenges faced by researchers engaged with designing temporary cardio-vascular devices in angioplasty are particularly sophisticated [8]. The small thickness of the struts of the stent stipulates demanding requirements to the alloy's physical, chemical and mechanical properties [22,23]. For instance, the yield strength should exceed 250 MPa to minimise any possible accidental plastic deformation of the stent during eluting.…”

Section: Introductionmentioning

confidence: 99%

The Functional Properties of Mg–Zn–X Biodegradable Magnesium Alloys

et al. 2020

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The implantation of metallic devices in orthopaedic surgical procedures and coronary angioplasty is associated with the risk of various adverse events: (i) mechanical (premature failure), (ii) chemo-mechanical (corrosion and corrosion-fatigue degradation) and (iii) biomedical (chronic local inflammatory reactions, tissue necrosis, etc.). In this regard, the development of biodegradable implants/stents, which provide the necessary mechanical support for the healing period of the bone or the vessel wall and then are completely resorbed, has bright prospects. Magnesium alloys are the most suitable candidates for that purpose due to their superior mechanical performance, bioresorbability and biocompatibility. This article presents the results of the comparative research on several wrought biodegradable alloys, assessing their potential for biomedical applications. The Mg–Zn–X alloys with different chemical compositions and microstructures were produced using severe plastic deformation techniques. Functional properties pivotal for biomedical applications—mechanical strength, in vitro corrosion resistance and cytotoxic activity—were included in the focus of the study. Excellent mechanical performance and low cytotoxic effects are documented for all alloys with a notable exception for one of two Mg–Zn–Zr alloys. The in vitro corrosion resistance is, however, below expectations due to critical impurities, and this property has yet to be drastically improved through the cleaner materials fabrication processing before they can be considered for biomedical applications.

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Biodegradable stent

Cited by 32 publications

References 61 publications

Mechanical behavior of polymer-based vs. metallic-based bioresorbable stents

Mechanical behavior of polymer-based vs. metallic-based bioresorbable stents

Shape Memory Systems with Biodegradable Polyesters

The Functional Properties of Mg–Zn–X Biodegradable Magnesium Alloys

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