Long-term benefits of exercise training in patients with a systemic right ventricle

Bom, Teun van der; Winter, Michiel M.; Knaake, Jennifer L.; Cervi, Elena; Vries, Leonie S.C. de; Balducci, Anna; Meregalli, Paola G.; Pieper, Petronella G.; Dijk, Arie P.J. van; Bonvicini, Marco; Mulder, Barbara J.M.; Bouma, Berto J.

doi:10.1016/j.ijcard.2014.10.042

Cited by 30 publications

(15 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even short-term training leads to better efficiency parameters that persist for a long time. 9 In addition, the training does not lead them to the adverse remodeling. 32 It is interesting that the children, after surgery for ToF or TGA, assess their quality of life as similar to healthy children, even slightly overestimating their abilities.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the Degree of Exercise Tolerance in Children After Surgical Treatment of Complex Cardiac Defects, Assessed Using Ergospirometry and the Level of Brain Natriuretic Peptide

Mazurek

Szydłowski²,

Mazurek

et al. 2016

Medicine

View full text Add to dashboard Cite

Children who underwent surgery for complex congenital heart defects present worse exercise capacity than their healthy peers. In adults and adolescents, heart failure is assessed on the basis of clinical symptoms using the New York Heart Association (NYHA) score, while in an infant Ross scale; heart failure can also be evaluated by other parameters. The purpose of this study was to compare the degree of exercise tolerance in children after surgery for complex heart defects, assessed by the ratio of maximum oxygen uptake (VO2max) and the brain natriuretic peptide (N-terminal fragment of the prohormone brain-type natriuretic peptide [NT-proBNP]) concentration.The study group consisted of 42 children, ages 9 to 17 years (mean 14.00 ± 2.72). Among them there were 22 children with tetralogy of Fallot (ToF) after total correction, 18 children with transposition of the great arteries (d-TGA) after the arterial switch operation, and 2 children with single ventricle (SV) after the Fontan operation. All but 1 child were in NYHA class I. The control group consisted of 20 healthy children. Outcomes of interest were the ratio of VO2max, determined during ergospirometry, and the level of NT-proBNP. The statistical analysis was performed and the groups were considered significantly different for P < 0.05.There was no statistically significant correlation between NT-proBNP and maximum oxygen uptake (VO2) kg−1 min−1 in the study group compared with the control group.The VO2max in the test group had a mean value less (34.6 ± 8.0) than controls (38.4 ± 7.7), and the differences were statistically significant (P = 0.041). In contrast, the average concentration of NT-proBNP in the study group was higher than controls (117.9 ± 74.3 vs 18.0 ± 24.5), and these differences were statistically significant (P < 0.001).After operations for complex heart defects (ToF, TGA, and SV), children have worse heart function parameters and exercise capacity than the healthy population. To control this, we recommend postoperative ergospirometry and determination of NT-proBNP concentrations.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The aim of the operation is the connection of the superior and inferior vena cava to the pulmonary artery; unfortunately, this type of operation is burdened with a number of complications that affect the child's condition and subsequent exercise capacity. 7 – 9 …”

Section: Introductionmentioning

confidence: 99%

Comparison of the Degree of Exercise Tolerance in Children After Surgical Treatment of Complex Cardiac Defects, Assessed Using Ergospirometry and the Level of Brain Natriuretic Peptide

Mazurek

Szydłowski²,

Mazurek

et al. 2016

Medicine

View full text Add to dashboard Cite

show abstract

“…Small studies have shown that exercise training is safe and improves exercise tolerance and health-related quality of life in asymptomatic and symptomatic patients with ACHD 42. A multicentre randomised controlled trial involving 54 patients with systemic RV showed short-term improvement with training in peak VO 2 43 and better exercise capacity, BNP levels and increased survival of patients who keep on participating in regular sports at long-term follow-up 44. In adults with rToF, while high-intensity interval training improved exercise performance and vascular function, beneficial effects on cardiac autonomic function and quality of life were observed with moderate continuous exercise training 45.…”

Section: Adjunctive Advanced Hf Therapiesmentioning

confidence: 99%

Medical therapy for heart failure in adult congenital heart disease: does it work?

Gallego

Oliver

2019

Heart

View full text Add to dashboard Cite

“…Apolipoprotein E plays critical role in modulating the response to neurological injury after cardiopulmonary bypass in children [47]. Transcatheter aortic valve implantation is becoming a standard treatment for nonoperable and high-risk patients with symptomatic severe aortic valve stenosis (Table 2) [48]. Electroencephalography or magneto encephalography or volumetric measures of certain brain regions by using magnetic resonance imaging provide both accuracy and specificity and clarity about brain related abnormalities in children and adults.…”

Section: Diagnostic Biomarkersmentioning

confidence: 99%

Emerging Biomarkers of Congenital Heart Diseases and Disorders

Upadhyay

2016

JSRT

View full text Add to dashboard Cite

Present review aims to discuss new emerging biomarkers that could facilitate authentic and fast diagnosis of congenital heart diseases. The population of congenital heart disease patients is increasing regularly and serious complications in adults are also enormously exceeding in comparison to children. Most of these congenital defects are un-curable and becoming challenging to treat. However, for predicting the prognosis of patient's different types of biomarkers i.e. hemodynamic, physiological, genetic, molecular, immunological, clinical and therapeutic biomarkers are explained. For sequential assessment of major structural and functional defects in CHD (congenital heart diseases) patients various bioassays and scientific methods are used to integrate defects with symptoms to find therapeutic decisions, targets and goals. This article tries to explore therapeutic options and solutions of CHD on the basis of emerging biomarkers and assess the need to advent new potential authentic biomarkers.

show abstract

Long-term benefits of exercise training in patients with a systemic right ventricle

Cited by 30 publications

References 19 publications

Comparison of the Degree of Exercise Tolerance in Children After Surgical Treatment of Complex Cardiac Defects, Assessed Using Ergospirometry and the Level of Brain Natriuretic Peptide

Comparison of the Degree of Exercise Tolerance in Children After Surgical Treatment of Complex Cardiac Defects, Assessed Using Ergospirometry and the Level of Brain Natriuretic Peptide

Medical therapy for heart failure in adult congenital heart disease: does it work?

Emerging Biomarkers of Congenital Heart Diseases and Disorders

Contact Info

Product

Resources

About