Long-term attention deficits combined with subcortical and cortical structural central nervous system alterations in young adults born small for gestational age

Suffren, Sabrina; Angulo, Diego A.; Ding, Yang; Reyes, Pablo; Marín, Julián David Martínez; Hernández, José Tiberio; Charpak, Nathalie; Lodygensky, Gregory A.

doi:10.1016/j.earlhumdev.2017.04.016

Cited by 14 publications

(15 citation statements)

References 36 publications

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“…We observed an association between these SNPs and gray matter density in cortical areas involved in memory, attention, information processing, and decision-making, such as precuneus, superior and inferior temporal gyrus, frontal gyrus, and inferior parietal lobule, respectively (Shapiro et al, 2002;du Boisgueheneuc et al, 2006;Wallentin et al, 2006;Vickery and Jiang, 2009;Tops and Boksem, 2011). Clinical studies have been demonstrated that smaller volumes of frontal, parietal and occipital cortices were associated with the higher rates of ADHD (Botellero et al, 2017;Suffren et al, 2017). In fact, ADHD is a disorder associated with cognitive control and reward response.…”

Section: Discussionmentioning

confidence: 80%

Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes

et al. 2020

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Section: Discussionmentioning

confidence: 80%

Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes

et al. 2020

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“…This argument gains impetus from the findings of a study where hospital-initiated KMC given during early infancy in preterm infants did not show any statistically significant differences in development scores at age of one year of age but was associated with reduced school absenteeism, hyperactivity, aggressiveness, externalization, and socio-deviant conduct of young adults after 20 years of enrollment [9,12]. Considering the evidence that adults aged 20 years born small for gestational age at term had lower performances in subtests assessing attention and executive functions with lower volumes in the associated brain structures, it would be an important step forward to follow this cohort of infants and evaluate the effect of ciKMC in their long-term attentional performance [37]. We, therefore, plan to assess cognitive, higher executive functioning and early academic skills using validated tools with reliable psychometric properties in children from the primary cohort at ages 6-7 years.…”

Section: Discussionmentioning

confidence: 99%

Community initiated kangaroo mother care and early child development in low birth weight infants in India-a randomized controlled trial

et al. 2020

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Background: In a randomized controlled trial (RCT) with 8402 stable low birthweight (LBW) infants, majority being late preterm or term small for gestational age, community-initiated KMC (ciKMC) showed a significant improvement in survival. However, the effect of ciKMC on neurodevelopment is unclear. This is important to elucidate as children born with low birth weight are at high risk of neurodevelopmental deficits. In the first 552 stable LBW infants enrolled in the above trial, we evaluated the effect of ciKMC on neurodevelopmental outcomes during infancy. Method: This RCT was conducted among 552 stable LBW infants, majorly late preterm or term small for gestational age infants without any problems at birth and weighing 1500-2250 g at birth. The intervention comprised of promotion of skin-to-skin contact and exclusive breastfeeding by trained intervention delivery team through home visits. The intervention group mother-infant-dyads were supported to practice ciKMC till day 28 after birth or until the baby wriggled-out. All infants in the intervention and control groups received Home Based Post Natal Care (HBPNC) visits by government health workers. Cognitive, language, motor and socio-emotional outcomes were assessed at infant-ages 6-and 12-months using Bayley Scale of Infant Development (BSID-III). Other outcomes measured were infant temperament, maternal depression, maternal sense of competence, mother-infant bonding and home-environment. We performed post-hoc equivalence testing using two one-sided tests of equivalence (TOST) to provide evidence that ciKMC does not do harm in terms of neurodevelopment. Results: In the intervention arm, the median (IQR) time to initiate ciKMC was 48 (48 to 72) hours after birth. The mean (SD) duration of skin-to-skin-contact was 27.9 (3.9) days with a mean (SD) of 8.7 (3.5) hours per day. We did not find significant effect of ciKMC on any of the child developmental outcomes during infancy. The TOST analysis demonstrated that composite scores for cognitive, language and motor domains at 12 months among the study arms were statistically equivalent.

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“…Controversy exists regarding the nature of neurocognitive morbidity, which develops in SGA neonates. For example, some studies have shown neurocognitive deficits and decreased functional outcomes in SGA children, in particular attention deficit hyperactive disorder (ADHD) [ 12 , 18 , 19 ], while other studies did not find significant associations with SGA [ 14 , 20 ]. Our long-term follow up did not find an association between SGA and ADHD, but this may be explained by the fact that our study was hospital-based, and in most cases ADHD diagnosis is made in an outpatient setting.…”

Section: Discussionmentioning

confidence: 99%

“…Postmortem examination of human SGA brains shows a reduction in myelin lipids [ 11 ]. Interestingly, magnetic resonance imaging (MRI) studies of adolescents born as SGA were able to demonstrate a trend towards a smaller cerebral cortical, smaller frontal lobe, as well as smaller basal ganglia volume [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…This body of evidence suggests that neonates born as SGA are at an increased risk for developing long-term neurological disorders. Indeed, SGA has been associated with an increased risk for neurocognitive disorders such as attention-hyperactivity symptoms and poor academic achievements [ 12 , 13 ]. However, other studies were not able to demonstrate that SGA had a significant impact on neurological morbidity [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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The Association Between Delivery of Small-for-Gestational-Age Neonate and Their Risk for Long-Term Neurological Morbidity

Hadar

Wainstock

2020

JCM

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Small-for-gestational-age (SGA) is defined as a birth weight below the 10th or below the 5th percentile for a specific gestational age and sex. Previous studies have demonstrated an association between SGA neonates and long-term pediatric morbidity. In this research, we aim to evaluate the possible association between small-for-gestational-age (SGA) and long-term pediatric neurological morbidity. A population-based retrospective cohort analysis was performed, comparing the risk of long-term neurological morbidities in SGA and non-SGA newborns delivered between the years 1991 to 2014 at a single regional medical center. The neurological morbidities included hospitalizations as recorded in hospital records. Neurological hospitalization rate was significantly higher in the SGA group (3.7% vs. 3.1%, OR = 1.2, 95% CI 1.1–1.3, p < 0.001). A significant association was noted between neonates born SGA and developmental disorders (0.2% vs. 0.1%, OR = 2.5, 95% CI 1.7–3.8, p < 0.001). The Kaplan-Meier survival curve demonstrated a significantly higher cumulative incidence of neurological morbidity in the SGA group (log-rank p < 0.001). In the Cox proportional hazards model, which controlled for various Confounders, SGA was found to be an independent risk factor for long-term neurological morbidity (adjusted hazard ratio (HR) = 1.18, 95% CI 1.07–1.31, p < 0. 001). In conclusion, we found that SGA newborns are at an increased risk for long-term pediatric neurological morbidity.

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Long-term attention deficits combined with subcortical and cortical structural central nervous system alterations in young adults born small for gestational age

Cited by 14 publications

References 36 publications

Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes

Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes

Community initiated kangaroo mother care and early child development in low birth weight infants in India-a randomized controlled trial

The Association Between Delivery of Small-for-Gestational-Age Neonate and Their Risk for Long-Term Neurological Morbidity

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