Long-term atorvastatin improves age-related endothelial dysfunction by ameliorating oxidative stress and normalizing eNOS/iNOS imbalance in rat aorta

Treatment with high dose of atorvastatin reduces vascular injury in diabetic rats

“…In fact, previous reports have demonstrated that atorvastatin treatment reduces the endothelial dysfunction by increasing the release of NO [34][35][36] besides reducing the nitroxidative stress [35] and oxidative stress [36]. Corroborating these studies, our findings suggest that NO participation, in response to phenylephrine was increased by atorvastatin treatment in diabetic rats.…”

Rho‐GTPase and Atherosclerosis: Pleiotropic Effects of Statins

“…For example, Wagner et al report that atorvastatin reduces inducible nitric oxide synthase expression in native endothelial cells in situ and the underlying mechanism is associated with inhibition of tumor necrosis factor‐α and interferon‐γ expressions . Furthermore, through normalization of eNOS/inducible nitric oxide synthase ratio, atorvastatin improves age‐related endothelial dysfunction as reported by Gong and colleagues …”

Deletion of Metallothionein Exacerbates Intermittent Hypoxia-Induced Oxidative and Inflammatory Injury in Aorta

“…NO plays a key signal molecule in regulating vascular function; it is generated by NO synthases (NOSs), which comprise endothelial NOS (eNOS), inducible NOS (iNOS), and neuronal NOS [46]. Intimal eNOS-derived NO is transported to the vascular smooth muscle cells of the vascular media and regulates vascular tension mainly by relaxing the vessels, thereby maintaining vascular function [47]. In our study, we showed that eNOS expression was upregulated in response to 3-day IH but significantly decreased at 8 weeks of IH.…”