Treatment with high dose of atorvastatin reduces vascular injury in diabetic rats

Simões, Fabiana Vieira; Batista, Priscila Rossi de; Botelho, Tatiani; Ribeiro-Júnior, Rogério Faustino; Padilha, Alessandra Simão; Vassallo, Dalton Valentim

doi:10.1016/j.pharep.2016.04.022

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…Our findings are in agreement with beneficial effects of atorvastatine on endothelium-dependent relaxation of the superior mesenteric artery (SMA) in aged HTG rats (Sotnikova et al , 2012 ). Among the other effects, atorvastatin improved endothelial function in aortas from diabetic rats (Simões et al , 2016 ), showed the positive impact on morphological and functional parameters of the vascular wall (Mikhin et al , 2016 ), and ameliorated oxidative stress and inflammatory reaction in rats with dyslipidemia (Zhang et al , 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Monotherapy of experimental metabolic syndrome: II. Study of cardiovascular effects

Knézl

Sotníková

Brnoliaková

et al. 2017

Interdisciplinary Toxicology

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Metabolic syndrome belongs to the most important risk factors of cardiovascular diseases. The aim of this study was to investigate changes in cardiovascular system induced by high cholesterol and high fat diet (HCHF) in HTG rats and their influence by a pyridoindole antioxidant – SMe1EC2 (S). The effects of S were compared with those of atorvastatin (A). Male HTG rats were fed HCHF (1% cholesterol + 7.5% lard) for 4 weeks. S and A were administered p.o., 50 mg/kg b.w. Following experimental groups were used: Wistar rats (W), hypertriglyceridemic rats (HTG), HTG rats fed HCHF (CHOL), HTG+S (S-HTG), CHOL+S (S-CHOL), and CHOL+A (A-CHOL). Values of blood pressure (BP) and selected ECG parameters were monitored in conscious animals, functions of the isolated heart and aorta were analyzed ex vivo. At the end of the experiment, systolic (sBP) and diastolic (dBP) blood pressure was increased in HTG and CHOL. S and A decreased BP in all treated groups. Accordingly with BP changes, the aortic endothelial function of CHOL was damaged. Both S and A administration ameliorated the endothelium-dependent relaxation to values of W. PQ and QTc intervals were prolonged in CHOL, while the treatment with S or A improved ECG findings. Prodysrhythmogenic threshold was decreased significantly in CHOL and both treatments returned it to the control values. In conclusion, HCHF increased BP, impaired endothelial relaxation of the aorta and potentiated susceptibility of myocardium to dysrhythmias. The effect of S on the changes induced by HCHF diet was more pronounced than that of A.

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Section: Discussionmentioning

confidence: 99%

Monotherapy of experimental metabolic syndrome: II. Study of cardiovascular effects

Knézl

Sotníková

Brnoliaková

et al. 2017

Interdisciplinary Toxicology

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Characterization of vascular dysregulation in meriones shawi after high-calorie diet feeding

Lyoussi

Cherkaoui-Tangi

Morel

et al. 2018

Clinical and Experimental Hypertension

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The present study was initiated to characterize vascular dysregulations (contraction and relaxation) associated with metabolic defects in Merions shawi, a rodent from the gerbillidae family, submitted to 12 weeks high-calorie diet. This diet induces a type 2 diabetes/metabolic syndrome phenotype with hypertension. In diabetic meriones, body weight increase was associated with hyperglycemia, increased insulinemia, and insulin resistance. Compared to lean meriones, diabetic meriones showed decreased aorta contraction to noradrenaline, which was normalized after NOS inhibition. Endothelium-dependent relaxation to carbachol was enhanced, while relaxing effects of the NO donor SNAP and of diazoxide were unchanged. Insulin-evoked relaxation was depressed in aorta from diabetic meriones, and L-arginine relaxed contracted arteries from diabetic meriones, but not from lean meriones. Urine NOX level and iNOS mRNA muscle expression were significantly higher in diabetic meriones compared to lean animals. These data strongly suggest that iNOS may have a pathogenic role in vascular dysfunction observed in diet-induced diabetic meriones.

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Treatment with high dose of atorvastatin reduces vascular injury in diabetic rats

Cited by 2 publications

References 52 publications

Monotherapy of experimental metabolic syndrome: II. Study of cardiovascular effects

Monotherapy of experimental metabolic syndrome: II. Study of cardiovascular effects

Characterization of vascular dysregulation in meriones shawi after high-calorie diet feeding

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