Long term assessment of intralipotherapy in Madelung’s disease

Scevola, Silvia; Nicoletti, G.; Neri, Antonino; Faga, Angela

doi:10.4103/0970-0358.146638

Cited by 6 publications

(8 citation statements)

References 11 publications

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“…It was treated surgically without a second recurrence at 32 months of follow-up [ 10 ]. The other two patients ( Table 1 c) had both experienced a successful prior surgical excision [ 18 ]. And this study showed that intralipotherapy achieved a 2.5% reduction in average size and had a 33% recurrence rate [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…The other two patients ( Table 1 c) had both experienced a successful prior surgical excision [ 18 ]. And this study showed that intralipotherapy achieved a 2.5% reduction in average size and had a 33% recurrence rate [ 18 ]. Medical therapy was described in five reports.…”

Section: Resultsmentioning

confidence: 99%

“…Some reports recommended intralipotherapy as a noninvasive treatment of Madelung's disease, in which the mass was injected with phosphatidylcholine/deoxycholate. Scevola et al confirmed the efficacy of intralipotherapy after long-term assessment [ 18 ]. Intralipotherapy mainly limits the growth of adipose masses and is not highly effective in reducing their volume.…”

Section: Discussionmentioning

confidence: 99%

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Madelung’s Disease: Lipectomy or Liposuction?

Chen

Fang

Wang

et al. 2018

BioMed Research International

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Background Madelung's disease is a rare lipid metabolic disorder characterized by diffuse, uncapsulated lipomas in the neck, shoulder, and other areas. It mainly affects middle-aged men and is related to alcohol abuse, and the cause is not clear. Surgical treatments include lipectomy and liposuction. Methods This systematic review analyzed the treatment of Madelung's disease described in 52 articles including complete patient details, published between 2000 and 2015, and retrieved from the Web of Science, PubMed, Medline, and Embase. Results Lipectomy was performed in most cases and achieved more complete removal and better control of iatrogenic lesions of nearby structures than liposuction. Liposuction achieved good cosmetic results and is simpler and less invasive than lipectomy, but clinical experience is limited. Conclusions Both lipectomy and liposuction have advantages and drawbacks. Surgeons should base the choice of optimal treatment on patient characteristics. Novel surgical techniques and etiologically targeted treatments hold promise as future therapies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Madelung’s Disease: Lipectomy or Liposuction?

Chen

Fang

Wang

et al. 2018

BioMed Research International

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“…We found no studies using ultrasonography for the monitoring of the procedure. Ultrasonography was used only to monitor postoperative edema ( 5 ) , as well as to present treatment outcomes after the use of PC-based preparation compared to two cases of Madelung’s disease ( 17 ) .…”

Section: Discussionmentioning

confidence: 99%

The efficacy of high-frequency ultrasound-guided injection lipolysis in reducing fat deposits located on the inside of the knees

et al. 2020

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Introduction: Many women consider local fat deposits unacceptable for aesthetic reasons as they have negative impact on appearance and thus, contribute to reduced self-esteem. Injection lipolysis (intralipotherapy) may be an alternative for conventional liposuction in reducing fat deposits. Aim: The aim of this paper was to assess the efficacy of high-frequency ultrasound-guided injection of deoxycholic acid (intralipotherapy) to remove fat deposits on the inner side of knees. Materials and methods: The procedure was performed in 7 women (14 inner sides of knees). The formulation was administered under high-frequency ultrasound guidance. The procedure was performed twice at 4-week intervals in each patient. Highfrequency ultrasound guidance was used to monitor such parameters as the thickness of the dermis (DermaMed, Dramiński S.A.) or the subcutaneous tissue (Philips Epiq 5, USA). Ultrasound was performed both before and after treatment. Additionally, anthropometric measurements were taken, a questionnaire was performed, and a photographic documentation was recorded. Results: Reduction in knee circumference and subcutaneous tissue occurred in 71.42% of patients. Conclusions: Intralipolysis with deoxycholic acid formulation is an effective method for reducing fat deposits on the inner part of the knees. Ultrasonography proved to be a useful method to monitor the procedure (correct administration of the preparation) and to assess treatment outcomes. A small sample size was a limitation of our study; therefore further studies are needed.

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“…A differential diagnosis should be made with: Cushing syndrome; partial familial Dunnigan lipodystrophies (determined by mutations in the LMNA gene); familial angiolipomatosis; simple obesity; neck cysts; lymphoma; leukemia and soft tissue sarcoma; spiradenocarcinoma; and salivary and thyroid gland disease, is necessary [37][38][39][40][41]45,46,50,51]. A biopsy can exclude malignancy or prove the concomitant presence of liposarcoma or an intramyxoid sarcoma [10,14,15,[52][53][54][55][56][57][58][59][60]. Liver disease is a common comorbidity of BSA, and acute renal failure may also occur [10,20,[24][25][26][27][28]50,51].…”

Section: Differential Diagnosis Comorbidities and Malignant Transform...mentioning

confidence: 99%

Madelung’s Disease Evolving to Liposarcoma: An Uncommon Encounter

Lungu,

Oprea,

Stoleriu

et al. 2024

Life

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(1) Background: Madelung’s disease—known also as Benign Symmetric Adenolipomatosis (BSA) or Multiple Symmetric Lipomatosis (MSL), is a rare subcutaneous tissue disease characterized by the proliferation of non-encapsulated fat tissue with mature adipocytes. Patients develop symmetrical fatty deposits of varying sizes, (located particularly around the neck, shoulders, upper and middle back, arms, abdomen, and thighs), having clinical, esthetic, and psychiatric repercussions. (2) Methods: We report a case diagnosed with BSA upon admission to the Neurological and Internal Medicine Departments of the Emergency Clinical Hospital of Galati. (3) Results: This patient developed compressive phenomena and liposarcoma with liver metastasis, followed by death shortly after hospital presentation. The histopathology examination confirmed right latero-cervical liposarcoma and round cell hepatic metastasis. The specific metabolic ethiopathogenic mechanism has not been elucidated, but the adipocytes of BSA are different from normal cells in proliferation, hormonal regulation, and mitochondrial activity; a rare mitochondrial gene mutation, together with other interacting genetic or non-genetic factors, have been considered in recent studies. A thorough literature search identified only three cases reporting malignant tumors in BSA patients. (4) Conclusions: The goal of our paper is to present this rare case in the oncogenic synergism of two tumors. In the management of this BSA disorder, possible malignant transformation should be considered, although only scarce evidence was found supporting this.

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Long term assessment of intralipotherapy in Madelung’s disease

Cited by 6 publications

References 11 publications

Madelung’s Disease: Lipectomy or Liposuction?

Madelung’s Disease: Lipectomy or Liposuction?

The efficacy of high-frequency ultrasound-guided injection lipolysis in reducing fat deposits located on the inside of the knees

Madelung’s Disease Evolving to Liposarcoma: An Uncommon Encounter

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