Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use

Škrlová, Kateřina; Rybková, Zuzana; Stachurová, Tereza; Zagora, Jakub; Malachová, Kateřina; Měřínská, Dagmar; Gabor, Roman; Havlíček, Miroslav; Muñoz‐Bonilla, Alexandra; Plachá, Daniela

doi:10.1016/j.polymertesting.2022.107760

Cited by 6 publications

(3 citation statements)

References 68 publications

(104 reference statements)

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“…A typical polymer exhibiting antibacterial properties contains cationic groups that allow its adsorption on the anionic membrane and affect the deterioration of the cell membrane by interfering with the transport of compounds and hydrophobic groups that insert into and disrupt the bilipid membrane [ 14 , 15 ]. Polylactide itself or its copolymers indeed have a noticeable bacteriostatic effect [ 16 ]. However, it is insignificant and limited.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications

et al. 2023

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The article presents the results of the synthesis and characteristics of the amphiphilic block terpolymers, built of a hydrophilic polyesteramine block, and hydrophobic blocks made of lactidyl and glycolidyl units. These terpolymers were obtained during the copolymerization of L-lactide with glycolide carried out in the presence of previously produced macroinitiators with protected amine and hydroxyl groups. The terpolymers were prepared to produce a biodegradable and biocompatible material containing active hydroxyl and/or amino groups, with strong antibacterial properties and high surface wettability by water. The control of the reaction course, the process of deprotection of functional groups, and the properties of the obtained terpolymers were made based on 1H NMR, FTIR, GPC, and DSC tests. Terpolymers differed in the content of amino and hydroxyl groups. The values of average molecular mass oscillated from about 5000 g/mol to less than 15,000 g/mol. Depending on the length of the hydrophilic block and its composition, the value of the contact angle ranged from 50° to 20°. The terpolymers containing amino groups, capable of forming strong intra- and intermolecular bonds, show a high degree of crystallinity. The endotherm responsible for the melting of L-lactidyl semicrystalline regions appeared in the range from about 90 °C to close to 170 °C, with a heat of fusion from about 15 J/mol to over 60 J/mol.

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Section: Introductionmentioning

confidence: 99%

Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications

et al. 2023

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“…PLA is mainly used in the production of disposable consumer goods in the packaging industry, e.g., loose-fill packaging, compost bags, food packaging and disposable tableware [6] and in the textile industry, e.g., disposable clothing. It also has biomedical applications such as surgical threads, in the production of implants [7], scaffolds for bone regeneration [8] or drug delivery microsphere [9]. At the same time, the properties of polylactide depend on the constituent isomers, molecular weight, processing temperature and annealing time [10].…”

Section: Introductionmentioning

confidence: 99%

Study of Argon and Oxygen Mixtures in Low Temperature Plasma for Improving PLA Film Wettability

Izdebska‐Podsiadły

2023

Coatings

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Oxygen (O2) and argon (Ar) plasma give a significant improvement in the wettability of PLA films. This study investigates the effectiveness of plasma activation with a mixture of these two gases. The study includes contact angle measurements with water and diiodomethane and calculation of surface free energy (SFE) together with its polar and dispersion components. In addition, a chemical analysis of the surface, surface roughness, weight loss and the change in tensile strength were examined. As a result of the study, it was found that the use of a mixture of oxygen and argon during the plasma activation of the polylactide film gives better improvement in wettability than the use of pure gases. Moreover, the use of a mixture of these gases in equal proportions turned out to be the most effective, providing the highest value of the SFE and its polar component, as well as the lowest value of the water contact angle. Furthermore, plasma activation with this gas mixture results in reduced surface etching compared to other gas compositions, which manifests itself in lower weight reduction and an insignificant change in tensile strength.

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“…Polylactic acid (PLA), a polyester made from lactic acid (LA), which is derived from the fermentation of corn starch and other polysaccharides, is one of the most promising biodegradable thermoplastic materials [10]. Furthermore, it has been demonstrated that prepared and characterized PLA-based composites, when mixed with four different antimicrobial fillers (silver, hexadecylpyridinium, hexadecyltrimethylammonium bromides anchored on vermiculite, graphene oxide matrices in an amount of 1% wt), has proven significant antimicrobial properties concerning their antimicrobial character for possible use in the production of medical stents [11]. PLA can be easily modified by using different fillers to develop nano-composites with new physical, mechanical, and antimicrobial characteristics [12].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Properties and Characterization of a Hybrid 3D Printed Antimicrobial Composite Material Using FFF Process: Innovative and Swift

Ahmed

Al‐Marzouqi

Nazir

et al. 2023

IJMS

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Novel strategies and materials have gained the attention of researchers due to the current pandemic, the global market high competition, and the resistance of pathogens against conventional materials. There is a dire need to develop cost-effective, environmentally friendly, and biodegradable materials to fight against bacteria using novel approaches and composites. Fused filament fabrication (FFF), also known as fused deposition modeling (FDM), is the most effective and novel fabrication method to develop these composites due to its various advantages. Compared to metallic particles alone, composites of different metallic particles have shown excellent antimicrobial properties against common Gram-positive and Gram-negative bacteria. This study investigates the antimicrobial properties of two sets of hybrid composite materials, i.e., Cu-PLA-SS and Cu-PLA-Al, are made using copper-enriched polylactide composite, one-time printed side by-side with stainless steel/PLA composite, and second-time with aluminum/PLA composite respectively. These materials have 90 wt.% of copper, 85 wt.% of SS 17-4, 65 wt.% of Al with a density of 4.7 g/cc, 3.0 g/cc, and 1.54 g/cc, respectively, and were fabricated side by side using the fused filament fabrication (FFF) printing technique. The prepared materials were tested against Gram-positive and Gram-negative bacteria such as Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), Salmonella Poona (S. Poona), and Enterococci during different time intervals (5 min, 10 min, 20 min, 1 h, 8 h, and 24 h). The results revealed that both samples showed excellent antimicrobial efficiency, and 99% reduction was observed after 10 min. Hence, three-dimensional (3D) printed polymeric composites enriched with metallic particles can be utilized for biomedical, food packaging, and tissue engineering applications. These composite materials can also provide sustainable solutions in public places and hospitals where the chances of touching surfaces are higher.

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Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use

Cited by 6 publications

References 68 publications

Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications

Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications

Study of Argon and Oxygen Mixtures in Low Temperature Plasma for Improving PLA Film Wettability

Investigating the Properties and Characterization of a Hybrid 3D Printed Antimicrobial Composite Material Using FFF Process: Innovative and Swift

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